Motif ID: Hoxa2
Z-value: 1.177
Transcription factors associated with Hoxa2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa2 | ENSMUSG00000014704.8 | Hoxa2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 186 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 49.7 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 9.6 | 38.3 | GO:0060032 | notochord regression(GO:0060032) |
| 12.3 | 36.8 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.3 | 28.5 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 4.0 | 28.0 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 5.5 | 27.3 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.3 | 24.3 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 3.7 | 18.3 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
| 1.2 | 13.0 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 2.7 | 10.7 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.2 | 9.9 | GO:0021591 | ventricular system development(GO:0021591) |
| 1.5 | 9.1 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.5 | 9.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 8.6 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.1 | 8.0 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.3 | 7.1 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.1 | 7.1 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 7.1 | GO:0051301 | cell division(GO:0051301) |
| 0.1 | 6.7 | GO:0007051 | spindle organization(GO:0007051) |
| 0.6 | 6.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 90 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 38.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 6.2 | 36.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.3 | 27.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 15.8 | GO:0005776 | autophagosome(GO:0005776) |
| 1.2 | 10.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 9.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 8.5 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.2 | 8.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 8.2 | GO:0043679 | axon terminus(GO:0043679) |
| 0.9 | 7.8 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 7.6 | GO:0005856 | cytoskeleton(GO:0005856) |
| 0.2 | 7.0 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.2 | 6.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 6.6 | GO:0000922 | spindle pole(GO:0000922) |
| 1.0 | 6.3 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.4 | 6.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 1.5 | 6.0 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.6 | 5.9 | GO:0000805 | X chromosome(GO:0000805) |
| 0.9 | 5.4 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.2 | 5.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 130 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 55.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 1.1 | 38.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 1.8 | 36.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.9 | 27.3 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.5 | 24.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 2.3 | 18.3 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.0 | 17.8 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 14.9 | GO:0016773 | phosphotransferase activity, alcohol group as acceptor(GO:0016773) |
| 0.1 | 13.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 4.3 | 13.0 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.4 | 11.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 10.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 9.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 9.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.4 | 7.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.8 | 6.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.2 | 6.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.5 | 6.0 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.3 | 5.9 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.4 | 5.8 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 33 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 49.0 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 1.2 | 38.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 35.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 14.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 13.3 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.2 | 6.3 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.2 | 6.0 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 5.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 4.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.6 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.2 | 4.4 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 4.1 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 4.0 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.0 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 1.6 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.4 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 50.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 41.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.7 | 36.8 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 14.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 12.4 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 11.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 9.0 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 8.4 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 8.0 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 6.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.4 | 6.0 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 6.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 6.0 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 6.0 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.5 | 5.0 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 5.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 4.8 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 4.3 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.2 | 4.1 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 3.9 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
