Motif ID: Hoxa4

Z-value: 1.060


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 15.395 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr7_-_19699008 12.517 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr4_+_144892813 10.873 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_-_77519565 9.535 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr2_+_170731807 9.416 ENSMUST00000029075.4
 Dok5
docking protein 5
chr4_+_144893077 8.695 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 8.060 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr12_+_38780284 7.038 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr14_-_79771305 6.753 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr3_+_86070915 6.358 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr12_+_38780817 5.857 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr2_+_90885860 5.319 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr18_+_37435602 5.075 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr18_+_37355271 4.549 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chr5_+_137030275 4.303 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr15_+_32920723 3.457 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr15_-_56694525 3.413 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr18_+_76059458 3.372 ENSMUST00000167921.1
 Zbtb7c
zinc finger and BTB domain containing 7C
chr18_+_37447641 3.336 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr12_+_38781093 3.319 ENSMUST00000161513.1
 Etv1
ets variant gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 27.7 GO:0042572 retinol metabolic process(GO:0042572)
2.1 22.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 16.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
5.1 15.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
4.2 12.5 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.6 9.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 8.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 8.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 7.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 6.6 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.3 6.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 4.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.3 4.3 GO:0043084 penile erection(GO:0043084)
1.3 4.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.9 3.4 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 3.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
1.1 3.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 3.3 GO:0001553 luteinization(GO:0001553)
0.1 3.3 GO:0007616 long-term memory(GO:0007616)
1.0 3.0 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0005887 integral component of plasma membrane(GO:0005887)
4.2 12.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 11.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 7.7 GO:0001650 fibrillar center(GO:0001650)
0.0 6.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.4 GO:0048786 presynaptic active zone(GO:0048786)
0.1 4.3 GO:0030667 secretory granule membrane(GO:0030667)
0.5 3.3 GO:0044308 axonal spine(GO:0044308)
0.1 3.3 GO:0005871 kinesin complex(GO:0005871)
0.0 3.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)
0.0 2.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.3 GO:0035371 microtubule plus-end(GO:0035371)
0.7 2.2 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 2.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.2 GO:0030175 filopodium(GO:0030175)
0.0 2.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 2.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.7 2.0 GO:0044299 C-fiber(GO:0044299)
0.2 2.0 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 27.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 17.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 17.0 GO:0005509 calcium ion binding(GO:0005509)
0.3 12.8 GO:0005158 insulin receptor binding(GO:0005158)
4.2 12.5 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 10.7 GO:0003682 chromatin binding(GO:0003682)
0.1 9.5 GO:0002039 p53 binding(GO:0002039)
0.0 7.6 GO:0003779 actin binding(GO:0003779)
0.0 6.0 GO:0000287 magnesium ion binding(GO:0000287)
0.9 5.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 5.0 GO:0070064 proline-rich region binding(GO:0070064)
0.4 4.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 4.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 4.1 GO:0005125 cytokine activity(GO:0005125)
0.2 4.0 GO:0030275 LRR domain binding(GO:0030275)
0.1 3.6 GO:0043014 alpha-tubulin binding(GO:0043014)
1.1 3.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.5 3.3 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 3.3 GO:0003777 microtubule motor activity(GO:0003777)
0.4 3.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 26.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 20.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 16.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 3.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 3.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 2.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 12.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 11.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 4.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.0 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 4.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 3.4 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.6 1.8 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.8 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 1.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 1.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.4 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1