Motif ID: Hoxa4
Z-value: 1.060
Transcription factors associated with Hoxa4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa4 | ENSMUSG00000000942.10 | Hoxa4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 15.4 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 4.2 | 12.5 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 2.5 | 27.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 2.1 | 22.6 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 1.3 | 4.0 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 1.1 | 3.3 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 1.0 | 3.0 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.9 | 2.6 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.9 | 3.4 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 2.1 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.6 | 9.4 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.6 | 1.7 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.6 | 1.7 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.5 | 1.1 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
| 0.5 | 2.0 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.5 | 2.7 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.4 | 3.0 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.4 | 1.1 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.3 | 2.1 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.3 | 2.0 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.3 | 3.4 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.3 | 4.3 | GO:0043084 | penile erection(GO:0043084) |
| 0.3 | 2.2 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.3 | 6.4 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.3 | 1.8 | GO:1904587 | response to glycoprotein(GO:1904587) |
| 0.3 | 0.5 | GO:0072179 | nephric duct formation(GO:0072179) |
| 0.3 | 2.2 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.3 | 1.6 | GO:0030916 | otic vesicle formation(GO:0030916) semicircular canal morphogenesis(GO:0048752) |
| 0.2 | 1.9 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.2 | 0.7 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.2 | 0.6 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.2 | 0.8 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.2 | 16.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 0.7 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.2 | 1.5 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.2 | 1.4 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.2 | 3.3 | GO:0001553 | luteinization(GO:0001553) |
| 0.2 | 2.2 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.2 | 2.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 1.1 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 1.5 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 0.3 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) |
| 0.1 | 2.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.1 | 1.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 1.0 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.1 | 1.3 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 0.4 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.1 | 2.5 | GO:0007614 | short-term memory(GO:0007614) |
| 0.1 | 1.4 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
| 0.1 | 2.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 1.1 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.1 | 0.5 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.1 | 0.5 | GO:0051661 | maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684) |
| 0.1 | 8.7 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 0.9 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 3.3 | GO:0007616 | long-term memory(GO:0007616) |
| 0.1 | 1.2 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.1 | 1.6 | GO:0006007 | glucose catabolic process(GO:0006007) |
| 0.1 | 1.6 | GO:0051447 | negative regulation of meiotic cell cycle(GO:0051447) |
| 0.1 | 1.9 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.1 | 0.8 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 8.5 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 1.4 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.1 | 2.0 | GO:0010043 | response to zinc ion(GO:0010043) |
| 0.1 | 0.3 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.1 | 1.0 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.1 | 1.8 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 1.3 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.1 | 2.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 4.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 0.4 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.1 | 0.2 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 0.3 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 1.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.1 | 2.0 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.0 | 0.2 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.0 | 0.3 | GO:0042574 | isoprenoid catabolic process(GO:0008300) retinal metabolic process(GO:0042574) |
| 0.0 | 0.7 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.0 | 2.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.7 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.5 | GO:0050995 | negative regulation of lipid catabolic process(GO:0050995) |
| 0.0 | 0.4 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 0.2 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.0 | 0.2 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.7 | GO:0016556 | mRNA modification(GO:0016556) |
| 0.0 | 0.1 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.0 | 0.6 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 0.7 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 1.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 7.1 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.6 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.2 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 1.2 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 6.6 | GO:0007268 | chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) |
| 0.0 | 0.4 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.0 | 0.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 2.0 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.5 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.7 | 2.2 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
| 0.7 | 2.0 | GO:0044299 | C-fiber(GO:0044299) |
| 0.5 | 3.3 | GO:0044308 | axonal spine(GO:0044308) |
| 0.4 | 1.5 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.3 | 1.5 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 2.2 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 2.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 1.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 0.6 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 1.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 1.0 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.1 | 0.7 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 1.1 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 5.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 11.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.6 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.1 | 2.0 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.7 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 2.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 1.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 3.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 6.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 7.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.2 | GO:1990131 | Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 1.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.1 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.0 | 2.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 2.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 15.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 2.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 3.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.1 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 1.1 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.5 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 3.9 | 27.6 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.1 | 3.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.9 | 5.5 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.5 | 3.3 | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.5 | 2.4 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.4 | 3.0 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.4 | 4.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.4 | 2.0 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.4 | 1.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.3 | 2.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.3 | 12.8 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.2 | 1.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 1.1 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.2 | 4.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 4.0 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.2 | 2.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.2 | 5.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 1.7 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.2 | 1.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 0.6 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.2 | 2.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 1.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 2.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 1.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 1.1 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.1 | 1.8 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.1 | 2.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 1.4 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.1 | 2.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.8 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.1 | 2.1 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.1 | 9.5 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 1.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 3.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.4 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 1.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 2.6 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 0.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 1.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 0.4 | GO:0016615 | malate dehydrogenase activity(GO:0016615) |
| 0.1 | 2.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 1.8 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 1.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.6 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.1 | 0.5 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 1.5 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 2.2 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 0.9 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 17.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 4.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 3.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.2 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 17.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 1.8 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 6.0 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.1 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.0 | 0.3 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.3 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.1 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 0.7 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.1 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.0 | 7.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 1.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 10.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.2 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 0.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 26.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 3.5 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.2 | 9.4 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 16.1 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.5 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 2.2 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.3 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 3.3 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.1 | 0.1 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 1.6 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 2.6 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 1.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 1.4 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 3.2 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 1.9 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.0 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 3.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.3 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 2.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.4 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 12.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.6 | 1.8 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.5 | 1.4 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.4 | 11.8 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 4.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 3.4 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.2 | 5.4 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 2.9 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 3.0 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.4 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 4.0 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 0.9 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 1.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 0.8 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.1 | 1.6 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 4.0 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.3 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 1.1 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 1.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.7 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.1 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.8 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 1.5 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.8 | REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
