Motif ID: Hoxa5

Z-value: 0.918


Transcription factors associated with Hoxa5:

Gene SymbolEntrez IDGene Name
Hoxa5 ENSMUSG00000038253.6 Hoxa5



Activity profile for motif Hoxa5.

activity profile for motif Hoxa5


Sorted Z-values histogram for motif Hoxa5

Sorted Z-values for motif Hoxa5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_17574268 9.789 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_+_17574726 7.034 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr16_+_43508118 5.333 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr3_+_62419668 4.194 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr8_-_99416397 4.059 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chrX_+_66653003 4.015 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr16_+_43247278 3.473 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr5_+_66968559 3.231 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_3343893 3.127 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_-_116968969 2.960 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr17_-_81649607 2.918 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr2_+_4400958 2.795 ENSMUST00000075767.7
 Frmd4a
FERM domain containing 4A
chr8_+_71887264 2.792 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chr6_+_103510874 2.640 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr5_+_66968416 2.608 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr5_+_104459450 2.460 ENSMUST00000086831.3
 Pkd2
polycystic kidney disease 2
chr9_-_58313189 2.459 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr8_+_57455898 2.426 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr5_-_62766153 2.390 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_13398688 2.339 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 16.8 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 10.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 9.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 7.5 GO:0007416 synapse assembly(GO:0007416)
0.1 4.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.6 4.4 GO:0044838 cell quiescence(GO:0044838)
0.3 4.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 4.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.4 3.6 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 3.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 3.0 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.6 2.9 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 2.8 GO:0034605 cellular response to heat(GO:0034605)
0.1 2.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.6 2.5 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.3 2.4 GO:2000232 regulation of rRNA processing(GO:2000232)
0.1 2.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.5 2.3 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) facioacoustic ganglion development(GO:1903375)
0.5 2.3 GO:0070459 prolactin secretion(GO:0070459)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.1 GO:0043083 synaptic cleft(GO:0043083)
0.3 4.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.6 GO:0009925 basal plasma membrane(GO:0009925)
0.4 2.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 2.5 GO:0005802 trans-Golgi network(GO:0005802)
0.6 2.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.6 2.3 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.1 2.2 GO:0044306 neuron projection terminus(GO:0044306)
0.0 2.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.4 2.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 2.1 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 19.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 11.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 6.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 4.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 3.2 GO:0030674 protein binding, bridging(GO:0030674)
1.0 3.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.7 2.9 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 2.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 2.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.4 2.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 2.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.8 2.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 2.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.6 2.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 2.1 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 2.0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 1.9 GO:0061665 SUMO ligase activity(GO:0061665)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 1.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.6 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_ATM_PATHWAY ATM pathway
0.0 1.0 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_CDC42_PATHWAY CDC42 signaling events
0.1 0.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.9 PID_GMCSF_PATHWAY GMCSF-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.9 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.5 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.4 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 0.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.9 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 0.8 REACTOME_AMYLOIDS Genes involved in Amyloids