Motif ID: Hoxa6

Z-value: 1.067


Transcription factors associated with Hoxa6:

Gene SymbolEntrez IDGene Name
Hoxa6 ENSMUSG00000043219.8 Hoxa6



Activity profile for motif Hoxa6.

activity profile for motif Hoxa6


Sorted Z-values histogram for motif Hoxa6

Sorted Z-values for motif Hoxa6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_37773555 25.404 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr16_+_42907563 24.336 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr1_+_19103022 22.373 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr14_-_118052235 15.482 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_+_38341068 15.075 ENSMUST00000133661.1
 Lhx2
LIM homeobox protein 2
chr1_-_165934900 14.889 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1


chr1_-_163313661 14.396 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr19_+_55894508 13.840 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_70474923 13.710 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr2_-_18048784 13.691 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr14_-_48665098 13.483 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr9_+_118478182 13.412 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_116038734 12.871 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr9_+_118478344 12.804 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr13_-_97747373 12.259 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr18_-_84086379 12.184 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr9_+_120929216 11.407 ENSMUST00000130466.1
 Ctnnb1
catenin (cadherin associated protein), beta 1
chr13_-_103764502 10.816 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr7_-_109170308 10.668 ENSMUST00000036992.7
 Lmo1
LIM domain only 1
chr2_+_181767040 10.288 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 52.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.7 35.3 GO:0030901 midbrain development(GO:0030901)
2.2 34.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.0 27.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
8.7 26.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
5.8 23.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
5.2 20.7 GO:0051884 regulation of anagen(GO:0051884)
1.6 18.6 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
2.6 18.0 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.3 17.7 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.6 17.4 GO:0060539 diaphragm development(GO:0060539)
0.1 16.7 GO:0007605 sensory perception of sound(GO:0007605)
1.3 16.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.6 15.5 GO:0006570 tyrosine metabolic process(GO:0006570)
1.2 15.1 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.6 14.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.8 13.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 13.0 GO:0043488 regulation of mRNA stability(GO:0043488)
1.4 12.7 GO:0048664 neuron fate determination(GO:0048664)
4.1 12.2 GO:0060023 soft palate development(GO:0060023)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 60.5 GO:0005667 transcription factor complex(GO:0005667)
0.2 34.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
3.3 29.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 20.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
2.0 17.7 GO:0030478 actin cap(GO:0030478)
0.1 16.1 GO:0032993 protein-DNA complex(GO:0032993)
0.6 15.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
4.7 14.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.9 13.0 GO:0042788 polysomal ribosome(GO:0042788)
0.0 10.8 GO:0005681 spliceosomal complex(GO:0005681)
0.2 10.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 6.5 GO:0097440 apical dendrite(GO:0097440)
0.0 6.3 GO:0005925 focal adhesion(GO:0005925)
1.5 6.1 GO:0008623 CHRAC(GO:0008623)
0.0 5.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 5.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 4.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 3.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.6 GO:0005581 collagen trimer(GO:0005581)
0.2 2.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 110.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 95.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.7 37.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
2.1 31.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 25.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.0 18.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.5 16.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.2 15.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
3.5 14.0 GO:0050436 microfibril binding(GO:0050436)
0.4 13.0 GO:0017091 AU-rich element binding(GO:0017091)
0.9 11.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 10.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 10.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
3.1 9.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.4 8.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 8.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 6.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.5 6.3 GO:0038191 neuropilin binding(GO:0038191)
0.1 5.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.5 4.2 GO:0039706 co-receptor binding(GO:0039706)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 33.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 27.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.6 26.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 18.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.6 17.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 11.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 10.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 7.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 5.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 27.0 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 19.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.5 17.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
1.6 11.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 7.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.4 6.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 5.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 4.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.4 2.2 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.1 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle