Motif ID: Hoxa7_Hoxc8

Z-value: 0.467

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 10.262 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 8.828 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 6.616 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_-_137169710 3.691 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr5_-_62766153 2.816 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_37458523 2.111 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_-_14621805 1.957 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr7_-_46667375 1.813 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr2_+_109917639 1.779 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_37518341 1.726 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr8_+_45885479 1.703 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr6_+_30541582 1.585 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr5_+_66968559 1.501 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr2_+_116067213 1.430 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_+_66968416 1.361 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr10_+_97482350 1.323 ENSMUST00000163448.2
 Dcn
decorin
chr9_-_103228420 1.295 ENSMUST00000126359.1
 Trf
transferrin
chr9_-_90255927 1.186 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr17_+_88440711 1.121 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr17_-_45659312 1.112 ENSMUST00000120717.1
 Capn11
calpain 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 19.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 6.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 3.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.5 3.6 GO:0019532 oxalate transport(GO:0019532)
0.0 3.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 2.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 1.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.8 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 1.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 1.3 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 1.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.2 1.0 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.3 0.9 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.9 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2 0.8 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.2 GO:0043197 dendritic spine(GO:0043197)
0.5 6.6 GO:0042581 specific granule(GO:0042581)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.7 GO:0030018 Z disc(GO:0030018)
0.0 1.5 GO:0031672 A band(GO:0031672)
0.2 1.3 GO:0097433 dense body(GO:0097433)
0.1 1.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.1 0.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 19.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 5.0 GO:0045296 cadherin binding(GO:0045296)
0.3 3.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 3.6 GO:0003924 GTPase activity(GO:0003924)
0.1 3.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 1.8 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 1.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events