Motif ID: Hoxa9_Hoxb9
Z-value: 0.680
Transcription factors associated with Hoxa9_Hoxb9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa9 | ENSMUSG00000038227.9 | Hoxa9 |
| Hoxb9 | ENSMUSG00000020875.8 | Hoxb9 |
Top targets:
Showing 1 to 20 of 105 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 52 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 42.7 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 1.0 | 15.6 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.2 | 11.1 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 7.6 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 1.5 | 7.3 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.6 | 4.8 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.9 | 4.6 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 1.4 | 4.3 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.2 | 4.0 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.4 | 3.3 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.6 | 3.1 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.0 | 3.0 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 3.0 | GO:0001764 | neuron migration(GO:0001764) |
| 0.7 | 2.9 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.0 | 2.6 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.3 | 2.3 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.0 | 2.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 2.3 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 2.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.6 | 1.9 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 15.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 10.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 2.4 | 7.3 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.1 | 4.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 4.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 3.3 | GO:0097449 | dense core granule(GO:0031045) astrocyte projection(GO:0097449) |
| 0.8 | 3.1 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.3 | 2.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 2.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 2.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 2.3 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 2.3 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.3 | 2.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 2.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.7 | 2.0 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.4 | 1.7 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 1.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.2 | 1.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 1.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 46 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.9 | GO:0003779 | actin binding(GO:0003779) |
| 1.0 | 20.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 12.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.2 | 7.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 6.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.2 | 4.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.9 | 4.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.8 | 3.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 3.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 3.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 2.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 2.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 2.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 2.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.4 | 1.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.3 | 1.7 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 1.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
Gene overrepresentation in C2:CP category:
Showing 1 to 14 of 14 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.6 | 6.5 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 4.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.3 | 4.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 3.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 3.1 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 3.1 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.5 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.3 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.9 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.8 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.1 | 1.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.3 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 43.8 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 15.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.8 | 7.3 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 5.6 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 5.0 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 4.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.3 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 4.0 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 3.3 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.2 | 3.1 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 3.0 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.7 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.3 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.1 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.0 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.9 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 0.9 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.6 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
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