Motif ID: Hoxb13

Z-value: 0.790


Transcription factors associated with Hoxb13:

Gene SymbolEntrez IDGene Name
Hoxb13 ENSMUSG00000049604.3 Hoxb13



Activity profile for motif Hoxb13.

activity profile for motif Hoxb13


Sorted Z-values histogram for motif Hoxb13

Sorted Z-values for motif Hoxb13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_84067063 2.961 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr3_+_106034661 2.716 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr3_-_150073620 2.387 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr14_-_77874887 2.033 ENSMUST00000022590.3
 Dnajc15
DnaJ (Hsp40) homolog, subfamily C, member 15
chr9_-_64022043 2.014 ENSMUST00000041029.5
 Smad6
SMAD family member 6
chr4_+_100776664 1.998 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr16_+_78930940 1.814 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr15_+_25773985 1.783 ENSMUST00000125667.1
 Myo10
myosin X
chr2_+_131491764 1.767 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase






chr5_-_118155379 1.750 ENSMUST00000049474.7
 Fbxw8
F-box and WD-40 domain protein 8
chr17_+_31433054 1.708 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr9_-_69451035 1.692 ENSMUST00000071565.5
 Gm4978
predicted gene 4978
chr6_+_42245907 1.672 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr2_-_118549668 1.638 ENSMUST00000090219.6
 Bmf
BCL2 modifying factor
chrM_+_8600 1.613 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr7_+_97400003 1.610 ENSMUST00000032882.8
 Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr3_-_49757257 1.571 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr5_-_135251209 1.554 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chrX_+_86191764 1.547 ENSMUST00000026036.4
 Nr0b1
nuclear receptor subfamily 0, group B, member 1
chr9_+_65346066 1.530 ENSMUST00000048184.2
 Pdcd7
programmed cell death 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 400 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 3.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 3.4 GO:0034644 cellular response to UV(GO:0034644)
0.2 3.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 3.1 GO:0032543 mitochondrial translation(GO:0032543)
0.5 2.9 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.1 2.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 2.6 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 2.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 2.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.7 2.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.7 2.0 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.5 2.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.3 2.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 2.0 GO:0016574 histone ubiquitination(GO:0016574)
0.0 2.0 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.2 1.9 GO:0006183 GTP biosynthetic process(GO:0006183)
0.1 1.9 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.4 1.8 GO:0046208 spermine catabolic process(GO:0046208)
0.1 1.8 GO:0060712 spongiotrophoblast layer development(GO:0060712)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 6.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 5.2 GO:0016459 myosin complex(GO:0016459)
0.1 4.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 4.2 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.1 3.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 3.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.1 3.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.9 GO:0000502 proteasome complex(GO:0000502)
0.0 2.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 2.7 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 2.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.4 GO:0008180 COP9 signalosome(GO:0008180)
0.6 2.2 GO:0060187 cell pole(GO:0060187)
0.2 2.1 GO:0000243 commitment complex(GO:0000243)
0.1 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 3.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 3.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.6 2.5 GO:0050436 microfibril binding(GO:0050436)
0.1 2.4 GO:0070628 proteasome binding(GO:0070628)
0.1 2.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.1 GO:0046332 SMAD binding(GO:0046332)
0.3 2.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.0 GO:0051015 actin filament binding(GO:0051015)
0.1 1.9 GO:0016805 dipeptidase activity(GO:0016805)
0.6 1.8 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 1.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 1.7 GO:0070697 activin receptor binding(GO:0070697)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.3 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 1.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 5.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 4.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.6 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2 3.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.2 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism