Motif ID: Hoxb2_Dlx2

Z-value: 0.791

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.637.1e-10Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 11.394 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr2_-_164171113 10.213 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr3_-_116253467 9.232 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr4_-_14621494 8.872 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr12_+_38780284 8.706 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 8.382 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr2_+_125136692 7.961 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr10_-_25200110 7.301 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr3_+_68572245 7.146 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr15_-_11037968 6.835 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr2_+_71528657 6.739 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr15_-_37458523 6.594 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_-_14621669 6.412 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr12_+_38783503 6.382 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr15_+_92597104 6.285 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr6_+_8948608 6.039 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr18_+_23415400 6.010 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr1_-_152625212 6.004 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr13_-_114458720 5.969 ENSMUST00000022287.5
 Fst
follistatin
chr5_+_139543889 5.880 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 28.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.8 26.7 GO:0019532 oxalate transport(GO:0019532)
3.6 10.9 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 10.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.6 10.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
2.3 9.2 GO:0061743 motor learning(GO:0061743)
1.5 9.2 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.1 7.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.4 7.1 GO:0008210 estrogen metabolic process(GO:0008210)
1.1 6.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 6.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 6.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.7 5.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 5.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 5.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.3 5.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 5.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 5.2 GO:0007416 synapse assembly(GO:0007416)
0.1 5.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 4.7 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 17.4 GO:0005615 extracellular space(GO:0005615)
0.1 10.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 9.6 GO:0072562 blood microparticle(GO:0072562)
0.1 8.7 GO:0001650 fibrillar center(GO:0001650)
0.5 7.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 7.8 GO:0030315 T-tubule(GO:0030315)
0.1 7.4 GO:0016605 PML body(GO:0016605)
0.1 5.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 5.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.5 5.3 GO:0071439 clathrin complex(GO:0071439)
0.1 5.1 GO:0016363 nuclear matrix(GO:0016363)
1.0 5.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 4.4 GO:0043083 synaptic cleft(GO:0043083)
0.4 4.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 4.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 3.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.1 2.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 2.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 26.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 21.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 9.4 GO:0003924 GTPase activity(GO:0003924)
2.3 9.2 GO:0001851 complement component C3b binding(GO:0001851)
0.5 8.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 7.4 GO:0030165 PDZ domain binding(GO:0030165)
0.3 7.3 GO:0016208 AMP binding(GO:0016208)
1.7 6.8 GO:0004966 galanin receptor activity(GO:0004966)
0.2 6.6 GO:0043014 alpha-tubulin binding(GO:0043014)
1.0 6.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.5 6.0 GO:0048185 activin binding(GO:0048185)
0.1 5.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 5.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 4.6 GO:0000287 magnesium ion binding(GO:0000287)
0.7 4.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 4.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.6 4.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.6 4.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 4.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 4.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 25.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 2.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 33.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.8 9.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 8.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 6.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 5.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.5 5.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.4 4.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 4.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3 4.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 3.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.1 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 3.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.7 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions