Motif ID: Hoxb3

Z-value: 1.260


Transcription factors associated with Hoxb3:

Gene SymbolEntrez IDGene Name
Hoxb3 ENSMUSG00000048763.5 Hoxb3



Activity profile for motif Hoxb3.

activity profile for motif Hoxb3


Sorted Z-values histogram for motif Hoxb3

Sorted Z-values for motif Hoxb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 23.485 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 19.263 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_32283511 15.657 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chrX_+_170009892 14.248 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chr4_-_14621805 13.929 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_-_85722474 12.196 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr12_+_74288735 11.634 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chrY_+_90785442 11.220 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
Erdr1


erythroid differentiation regulator 1


chr13_+_94083490 10.762 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr9_-_120068263 10.393 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr8_+_66386292 10.149 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr14_-_64455903 9.989 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr9_-_54661870 9.642 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr12_+_84069325 9.281 ENSMUST00000046422.4
ENSMUST00000072505.4
Acot5

acyl-CoA thioesterase 5

chr12_-_25096080 9.206 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr3_-_121263314 7.848 ENSMUST00000029777.7
Tmem56
transmembrane protein 56
chrY_+_90784738 7.550 ENSMUST00000179483.1
Erdr1
erythroid differentiation regulator 1
chr14_+_99298652 7.463 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr2_+_116067213 7.068 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_-_14621494 6.966 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr7_-_140154712 6.963 ENSMUST00000059241.7
Sprn
shadow of prion protein
chr2_+_109917639 6.605 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_12741324 6.588 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr5_+_134932351 6.169 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr18_+_37355271 5.905 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr10_-_125328957 5.519 ENSMUST00000063318.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr4_-_14621669 5.359 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chrX_+_170010744 5.173 ENSMUST00000178789.1
Gm21887
predicted gene, 21887
chr8_+_54954728 4.998 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr13_-_92030897 4.881 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr10_+_40349265 4.877 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr17_-_45659312 4.814 ENSMUST00000120717.1
Capn11
calpain 11
chr9_-_54661666 4.558 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_57387304 4.529 ENSMUST00000085241.5
Gm9962
predicted gene 9962
chr2_+_65620829 4.384 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr2_-_116067391 4.333 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chrX_-_9256899 4.105 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr2_+_91257323 4.030 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr10_+_116018213 4.016 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr7_+_67222544 3.990 ENSMUST00000058771.5
ENSMUST00000179106.1
Lysmd4

LysM, putative peptidoglycan-binding, domain containing 4

chr9_+_53771499 3.873 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr12_-_83487708 3.866 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr8_+_23411490 3.861 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr11_+_101665541 3.666 ENSMUST00000039388.2
Arl4d
ADP-ribosylation factor-like 4D
chr8_+_40354303 3.620 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr19_-_32196393 3.597 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr13_-_92483996 3.582 ENSMUST00000040106.7
Fam151b
family with sequence similarity 151, member B
chr3_+_65666223 3.513 ENSMUST00000099075.2
ENSMUST00000107848.1
ENSMUST00000161794.1
Lekr1


leucine, glutamate and lysine rich 1


chr4_-_42034726 3.499 ENSMUST00000084677.2
Gm21093
predicted gene, 21093
chr17_-_47834682 3.112 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr10_+_90071095 3.012 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr19_-_11604828 2.973 ENSMUST00000025582.4
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr9_-_75597643 2.820 ENSMUST00000164100.1
Tmod2
tropomodulin 2
chr16_-_52296924 2.691 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr4_+_102570065 2.669 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr9_-_96719404 2.590 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr10_-_83648631 2.587 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr9_+_119341487 2.513 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr12_-_98577940 2.511 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr5_-_118244861 2.509 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr2_-_45112890 2.476 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr9_-_55919605 2.462 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr1_+_115684727 2.447 ENSMUST00000043725.7
Cntnap5a
contactin associated protein-like 5A
chr7_-_44929410 2.358 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
Ap2a1



adaptor-related protein complex 2, alpha 1 subunit



chr11_-_121388186 2.221 ENSMUST00000106107.2
Rab40b
Rab40b, member RAS oncogene family
chr9_-_15301555 2.134 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr12_+_16653470 2.109 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr11_+_116843278 2.084 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr7_-_13053684 2.035 ENSMUST00000182490.1
Mzf1
myeloid zinc finger 1
chr2_+_36230426 1.993 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr5_+_63812447 1.969 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr9_+_119341294 1.936 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr10_-_128525859 1.933 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr13_-_56895737 1.925 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr5_-_106926245 1.918 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr8_-_104534630 1.760 ENSMUST00000162466.1
ENSMUST00000034349.9
Nae1

NEDD8 activating enzyme E1 subunit 1

chr5_+_136987019 1.756 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_-_45955183 1.732 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_-_96075655 1.718 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr7_+_3645267 1.665 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr12_+_21417872 1.637 ENSMUST00000180671.1
Gm4419
predicted gene 4419
chr1_+_165461037 1.619 ENSMUST00000027853.5
Mpc2
mitochondrial pyruvate carrier 2
chr10_+_116143881 1.576 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_-_77115145 1.567 ENSMUST00000081964.5
Hopx
HOP homeobox
chr8_+_113635550 1.551 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr9_+_94669876 1.501 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr7_-_67222412 1.481 ENSMUST00000181631.1
1700112J16Rik
RIKEN cDNA 1700112J16 gene
chr19_+_60811574 1.406 ENSMUST00000128357.1
ENSMUST00000119633.1
ENSMUST00000025957.8
Fam45a


family with sequence similarity 45, member A


chr6_+_113333304 1.406 ENSMUST00000147945.1
Ogg1
8-oxoguanine DNA-glycosylase 1
chr11_+_103116228 1.399 ENSMUST00000053063.5
Hexim1
hexamethylene bis-acetamide inducible 1
chr9_-_96719549 1.372 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr11_-_96075581 1.341 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr18_+_24603952 1.314 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr12_-_24493656 1.309 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr19_-_32061438 1.295 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr19_+_3323301 1.222 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr5_-_74531619 1.218 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr3_-_62506970 1.091 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chrX_+_100729917 1.073 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_156392829 1.028 ENSMUST00000088578.2
2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr8_+_113635787 0.991 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr2_-_161109017 0.979 ENSMUST00000039782.7
ENSMUST00000134178.1
Chd6

chromodomain helicase DNA binding protein 6

chr14_+_101653967 0.947 ENSMUST00000002289.6
Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr1_-_33814516 0.921 ENSMUST00000044455.5
ENSMUST00000115167.1
Zfp451

zinc finger protein 451

chr2_+_3424123 0.912 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr13_-_67332525 0.825 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr5_+_103425181 0.801 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr12_-_21417526 0.692 ENSMUST00000049531.9
ENSMUST00000155480.1
Ywhaq

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

chr5_-_137531204 0.680 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_+_145204523 0.674 ENSMUST00000085671.3
ENSMUST00000031601.7
Zkscan5

zinc finger with KRAB and SCAN domains 5

chr9_-_85749308 0.621 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr17_-_24886304 0.586 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr2_-_69712461 0.505 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr2_-_150255591 0.455 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr18_+_9958147 0.454 ENSMUST00000025137.7
Thoc1
THO complex 1
chr7_+_126695355 0.436 ENSMUST00000130498.1
Bola2
bolA-like 2 (E. coli)
chr1_-_184999549 0.342 ENSMUST00000027929.4
Mark1
MAP/microtubule affinity-regulating kinase 1
chr18_+_49832622 0.311 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr18_+_38296635 0.305 ENSMUST00000072376.5
ENSMUST00000170811.1
Rnf14

ring finger protein 14

chr14_-_46822232 0.275 ENSMUST00000111817.1
ENSMUST00000079314.5
Gmfb

glia maturation factor, beta

chr7_-_114636299 0.243 ENSMUST00000032906.4
ENSMUST00000032907.7
Calca

calcitonin/calcitonin-related polypeptide, alpha

chr6_+_37870786 0.210 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chrM_+_10167 0.198 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr11_+_69580359 0.193 ENSMUST00000005371.5
ENSMUST00000108658.3
ENSMUST00000171247.1
Trp53


transformation related protein 53


chr14_-_75754475 0.173 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr10_-_117148474 0.137 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chrM_+_7759 0.091 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr17_+_85028347 0.082 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr13_-_74807913 0.081 ENSMUST00000065629.4
Cast
calpastatin
chr7_-_45091713 0.059 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_138170992 0.051 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_+_118245226 0.041 ENSMUST00000049138.7
2410131K14Rik
RIKEN cDNA 2410131K14 gene
chrX_+_13280970 0.016 ENSMUST00000000804.6
Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 42.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
3.8 26.3 GO:0019532 oxalate transport(GO:0019532)
2.6 13.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
2.3 9.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
2.2 6.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
2.1 10.4 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
2.0 15.7 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
1.8 7.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
1.4 5.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
1.1 7.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.8 2.5 GO:0019085 early viral transcription(GO:0019085)
0.8 2.4 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.5 18.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.5 10.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5 2.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.5 2.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.4 1.8 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.4 2.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 6.8 GO:0048240 sperm capacitation(GO:0048240)
0.4 3.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.3 0.8 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.3 2.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 3.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 1.0 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 1.1 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.2 2.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.4 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.2 12.9 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 1.9 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 1.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 3.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.2 4.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 4.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 0.5 GO:0048296 negative regulation of isotype switching(GO:0045829) isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.2 1.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 5.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 3.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.9 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 3.1 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 2.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 5.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.2 GO:0090403 T cell proliferation involved in immune response(GO:0002309) regulation of purine nucleotide catabolic process(GO:0033121) negative regulation of purine nucleotide catabolic process(GO:0033122) oxidative stress-induced premature senescence(GO:0090403)
0.1 1.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 10.2 GO:0007568 aging(GO:0007568)
0.1 0.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 2.8 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.9 GO:0042755 eating behavior(GO:0042755)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 2.1 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 1.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.7 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 4.7 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.7 GO:0034766 negative regulation of ion transmembrane transport(GO:0034766)
0.0 1.3 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 1.3 GO:1904892 regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 6.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.3 8.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 10.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 64.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 1.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 1.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 2.7 GO:0042101 T cell receptor complex(GO:0042101)
0.1 27.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.9 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 5.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 4.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 7.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.0 3.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 19.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 3.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 5.9 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 42.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
3.9 15.7 GO:0031720 haptoglobin binding(GO:0031720)
3.3 10.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
2.4 26.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
2.1 10.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)
1.8 7.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.3 14.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1 4.4 GO:0008410 CoA-transferase activity(GO:0008410)
0.7 3.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.6 9.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.6 1.7 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.6 6.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.5 1.4 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.4 1.8 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.3 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.3 4.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 4.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 2.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.3 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 4.3 GO:0042287 MHC protein binding(GO:0042287)
0.2 1.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 3.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 4.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 1.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 0.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 2.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.8 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 2.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 4.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 2.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 5.0 GO:0005262 calcium channel activity(GO:0005262)
0.1 9.9 GO:0044325 ion channel binding(GO:0044325)
0.1 6.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 4.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.9 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0005168 neurotrophin TRK receptor binding(GO:0005167) neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 4.4 GO:0005525 GTP binding(GO:0005525)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 13.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 2.4 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.6 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 42.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 5.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 27.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 10.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 2.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 1.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 1.2 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.2 4.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 12.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 2.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 3.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta