Motif ID: Hoxb4
Z-value: 0.453
Transcription factors associated with Hoxb4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxb4 | ENSMUSG00000038692.7 | Hoxb4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 19.5 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 1.2 | 3.6 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 2.4 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.1 | 0.5 | GO:0070859 | positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.1 | 0.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.4 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 2.1 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.4 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 4.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 1.8 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.6 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 1.6 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.7 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.8 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.6 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.5 | 4.2 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.2 | 19.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 0.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.1 | 0.4 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 0.2 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.5 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 2.1 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.4 | 1.6 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.4 | 2.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 0.6 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.2 | 2.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 1.1 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 3.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 1.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.8 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.0 | 0.2 | GO:0097493 | muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.5 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 1.6 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.1 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.1 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.7 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.1 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 19.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 3.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.5 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.4 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 2.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
