Motif ID: Hoxb5
Z-value: 0.812
Transcription factors associated with Hoxb5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxb5 | ENSMUSG00000038700.3 | Hoxb5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.9 | 4.5 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.8 | 2.5 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.8 | 2.3 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.7 | 2.1 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.6 | 3.1 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.6 | 9.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.5 | 2.2 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.4 | 11.6 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.4 | 9.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.4 | 2.3 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.3 | 1.4 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.3 | 1.0 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566) |
| 0.3 | 0.9 | GO:0010248 | B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.3 | 7.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.3 | 1.5 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.3 | 1.3 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.2 | 2.4 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.2 | 1.4 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.2 | 2.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.2 | 3.7 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.2 | 0.5 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.1 | 1.8 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 2.5 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 1.1 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 4.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 2.8 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 1.9 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.4 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 0.5 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.2 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.1 | 0.2 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.1 | 0.9 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 1.6 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.4 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.0 | 0.5 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 1.0 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 1.9 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.2 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
| 0.0 | 2.2 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.0 | 0.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 3.2 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 0.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.0 | GO:0045852 | regulation of integrin biosynthetic process(GO:0045113) pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.5 | 7.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.4 | 2.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.2 | 1.5 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 2.5 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 1.0 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 1.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.4 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.1 | 1.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 9.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 2.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 3.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 2.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 3.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 2.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 7.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.8 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 7.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.3 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 11.6 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.1 | 4.2 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.8 | 2.5 | GO:0019966 | C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120) |
| 0.8 | 2.3 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.7 | 6.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.7 | 3.7 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.5 | 2.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.4 | 3.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.4 | 7.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.4 | 1.3 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.4 | 1.1 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.4 | 2.2 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 2.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.3 | 1.0 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 1.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.5 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 0.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 4.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 5.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 1.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.2 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 2.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 4.5 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 2.2 | GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114) |
| 0.0 | 1.6 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 2.8 | GO:0016247 | channel regulator activity(GO:0016247) |
| 0.0 | 1.9 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.0 | 1.5 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.4 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.4 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.0 | 3.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 10.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 1.9 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 0.9 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 4.0 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 1.5 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 1.7 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.0 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.2 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.4 | 5.7 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 2.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 2.8 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 2.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 2.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.4 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 3.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 2.8 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 0.5 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 3.1 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.0 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 2.8 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.5 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.9 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 1.3 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
