Motif ID: Hoxb7

Z-value: 3.443


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 70.520 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr12_-_31713873 61.984 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chrX_-_43167817 54.827 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr4_+_13751297 47.321 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_+_21111452 43.805 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_136171722 39.966 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr4_+_102589687 39.093 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr2_+_65930117 32.663 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr9_-_112187766 31.998 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr10_-_64090265 31.299 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_15196949 31.020 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr6_-_144209558 29.581 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr19_+_26605106 29.514 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr6_-_144209471 29.357 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr8_-_109251698 29.059 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr6_-_144209448 28.289 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr17_-_90088343 27.092 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr11_-_30198232 26.939 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr6_-_13839916 26.910 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chrX_-_43274786 25.869 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 436 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 166.4 GO:0006376 mRNA splice site selection(GO:0006376)
2.6 127.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
7.7 100.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
7.1 85.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
28.3 84.9 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.0 81.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
8.7 78.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
9.5 76.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.2 74.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
12.3 73.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.3 68.1 GO:0034605 cellular response to heat(GO:0034605)
6.6 59.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.8 56.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
5.0 55.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
7.8 54.8 GO:0019532 oxalate transport(GO:0019532)
5.9 52.8 GO:0071420 cellular response to histamine(GO:0071420)
3.3 50.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.2 49.5 GO:0008090 retrograde axonal transport(GO:0008090)
12.3 49.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
3.4 47.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 467.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 269.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.5 104.0 GO:0060076 excitatory synapse(GO:0060076)
4.1 78.4 GO:0071564 npBAF complex(GO:0071564)
3.0 78.4 GO:0000930 gamma-tubulin complex(GO:0000930)
4.6 69.2 GO:0043083 synaptic cleft(GO:0043083)
3.8 64.4 GO:0031045 dense core granule(GO:0031045)
3.0 60.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
6.3 57.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 56.2 GO:0030017 sarcomere(GO:0030017)
3.5 52.8 GO:1902711 GABA-A receptor complex(GO:1902711)
2.5 52.0 GO:0031430 M band(GO:0031430)
1.2 45.0 GO:0097458 neuron part(GO:0097458)
4.9 43.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.8 42.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.0 42.2 GO:0044295 axonal growth cone(GO:0044295)
10.4 41.6 GO:0031673 H zone(GO:0031673)
2.0 41.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.3 39.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 37.7 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 260 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 164.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 145.4 GO:0042803 protein homodimerization activity(GO:0042803)
4.1 107.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.7 100.6 GO:0030507 spectrin binding(GO:0030507)
1.9 98.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 89.4 GO:0004386 helicase activity(GO:0004386)
0.4 82.1 GO:0008017 microtubule binding(GO:0008017)
4.1 78.4 GO:0035198 miRNA binding(GO:0035198)
0.2 70.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
8.7 69.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 68.1 GO:0005516 calmodulin binding(GO:0005516)
0.3 65.3 GO:0005096 GTPase activator activity(GO:0005096)
7.7 61.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.6 58.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
2.0 57.1 GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.5 56.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.5 55.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
5.0 54.8 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
13.5 54.2 GO:0030348 syntaxin-3 binding(GO:0030348)
2.4 53.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 95.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.6 88.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.8 78.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.8 60.3 PID_LKB1_PATHWAY LKB1 signaling events
1.0 40.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.9 32.6 PID_ALK1_PATHWAY ALK1 signaling events
0.8 32.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
1.0 32.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.7 26.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.5 26.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.9 23.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.5 22.9 PID_FGF_PATHWAY FGF signaling pathway
0.4 22.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.9 21.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.3 20.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.7 19.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.7 17.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.8 17.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.5 17.5 PID_BMP_PATHWAY BMP receptor signaling
0.4 16.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 117.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
3.0 107.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
3.3 104.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
2.9 77.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.0 73.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
3.6 69.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
1.8 63.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
5.2 52.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.6 43.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 42.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.1 38.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
9.2 36.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.9 34.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 34.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
1.5 33.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
1.4 33.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
1.8 23.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.8 23.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.7 22.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.9 21.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation