Motif ID: Hoxb8_Pdx1

Z-value: 0.675

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_21111452 6.949 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_99044414 6.583 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chr1_-_126830632 6.235 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chrX_+_140367494 5.436 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chrX_-_43274786 5.399 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr8_+_118283719 5.100 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr2_-_120245157 4.951 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr1_-_126830786 4.738 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr7_+_73391160 4.605 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr13_+_93304799 4.571 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr1_-_33907721 4.550 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr12_+_58211772 4.370 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr3_+_65109343 4.048 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr9_+_40269273 3.992 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr6_-_138421379 3.974 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr4_+_102421518 3.787 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr9_+_40269202 3.766 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr1_+_159737510 3.688 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_102589687 3.616 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr6_+_96115249 3.492 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 11.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 9.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.9 7.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 7.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 7.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.7 6.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.4 5.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 5.5 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.2 5.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
1.0 5.1 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.4 4.6 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.3 4.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 4.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 3.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.3 3.8 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.9 3.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 3.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.8 3.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 3.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 11.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 10.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 8.0 GO:0043034 costamere(GO:0043034)
0.5 7.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 7.2 GO:0030426 growth cone(GO:0030426)
0.1 6.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 4.9 GO:0045298 tubulin complex(GO:0045298)
0.3 4.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 4.0 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.8 GO:0044295 axonal growth cone(GO:0044295)
1.2 3.7 GO:0072534 perineuronal net(GO:0072534)
0.1 3.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.8 2.5 GO:0048179 activin receptor complex(GO:0048179)
0.4 2.4 GO:0008091 spectrin(GO:0008091)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.1 1.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 10.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.1 7.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.7 7.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 6.2 GO:0003779 actin binding(GO:0003779)
0.0 6.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 4.8 GO:0055100 adiponectin binding(GO:0055100)
0.9 4.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 4.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 4.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.5 4.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.6 4.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 4.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 4.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 3.8 GO:0045499 chemorepellent activity(GO:0045499)
0.2 3.7 GO:0046625 sphingolipid binding(GO:0046625)
0.4 3.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 2.5 GO:0016361 activin receptor activity, type I(GO:0016361)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 6.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.6 PID_BMP_PATHWAY BMP receptor signaling
0.2 4.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 0.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 12.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 11.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 10.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 5.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 4.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 3.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 2.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 2.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.8 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.2 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism