Motif ID: Hoxc10

Z-value: 0.493


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25469742 6.137 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr14_+_13454010 5.492 ENSMUST00000112656.2
 Synpr
synaptoporin
chr2_-_25470031 5.111 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr3_-_63851251 4.804 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr14_+_13453937 4.048 ENSMUST00000153954.1
 Synpr
synaptoporin
chr4_+_144893127 3.348 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_+_104287855 2.518 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr5_-_62766153 2.329 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_-_49783259 2.089 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr11_-_84067063 2.050 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr5_-_111761697 2.032 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr15_+_25773985 1.889 ENSMUST00000125667.1
 Myo10
myosin X
chr1_-_45503282 1.775 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_-_49757257 1.628 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr6_-_136875794 1.587 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chrX_+_169685191 1.525 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr13_-_84064772 1.518 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr11_+_94211431 1.452 ENSMUST00000041589.5
 Tob1
transducer of ErbB-2.1
chr1_-_163289214 1.314 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr9_+_50575273 1.297 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 11.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 4.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017)
0.3 3.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 2.5 GO:0035904 aorta development(GO:0035904)
0.2 2.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 2.0 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.6 1.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 1.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 1.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 1.5 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.4 1.3 GO:0032817 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 0.9 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.0 0.9 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.3 0.8 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.3 0.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.8 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 9.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 2.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.6 1.8 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 1.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 0.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.5 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.5 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 4.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 3.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 2.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 1.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 0.8 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 0.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.7 GO:0004630 phospholipase D activity(GO:0004630)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.1 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling