Motif ID: Hoxc13_Hoxd13

Z-value: 0.906




Activity profile for motif Hoxc13_Hoxd13.

activity profile for motif Hoxc13_Hoxd13


Sorted Z-values histogram for motif Hoxc13_Hoxd13

Sorted Z-values for motif Hoxc13_Hoxd13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_8518801 22.712 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr17_+_75178911 14.121 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr17_+_75178797 12.223 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr5_+_17574268 10.959 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_+_108213086 7.874 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr12_-_34528844 7.503 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr18_+_69346143 7.180 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr17_-_6477102 7.101 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr1_-_56978534 7.007 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr16_-_74411776 6.897 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr4_+_54945038 6.449 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr17_+_6270475 6.314 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr7_+_67647405 5.183 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr16_+_23226014 4.721 ENSMUST00000178797.1
 St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr17_-_51826562 4.395 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
 Satb1




special AT-rich sequence binding protein 1




chr7_-_73537621 4.343 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr2_+_35132194 4.180 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr1_-_74124420 4.083 ENSMUST00000169786.1
 Tns1
tensin 1
chr14_-_118052235 4.042 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_+_72307413 3.983 ENSMUST00000027379.8
 Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 26.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 19.0 GO:0030010 establishment of cell polarity(GO:0030010)
1.8 11.0 GO:0003350 pulmonary myocardium development(GO:0003350)
1.3 7.9 GO:0042045 epithelial fluid transport(GO:0042045)
0.8 7.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.7 7.2 GO:0042118 endothelial cell activation(GO:0042118)
0.4 7.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.3 6.9 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 6.4 GO:0043392 negative regulation of DNA binding(GO:0043392)
1.1 6.3 GO:0009405 pathogenesis(GO:0009405)
1.0 5.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 5.1 GO:0006275 regulation of DNA replication(GO:0006275)
1.2 4.7 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.3 4.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 4.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 4.1 GO:0010761 fibroblast migration(GO:0010761)
1.0 4.0 GO:0071475 cellular hyperosmotic salinity response(GO:0071475) negative regulation of t-circle formation(GO:1904430)
0.7 4.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 3.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 3.6 GO:0043488 regulation of mRNA stability(GO:0043488)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.2 GO:0005794 Golgi apparatus(GO:0005794)
8.8 26.3 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 14.5 GO:0000118 histone deacetylase complex(GO:0000118)
2.6 7.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 6.9 GO:0030673 axolemma(GO:0030673)
0.4 5.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.5 4.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 4.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.4 GO:0005720 nuclear heterochromatin(GO:0005720)
1.0 4.0 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 4.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 3.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 3.5 GO:0016592 mediator complex(GO:0016592)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.7 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 26.3 GO:0050436 microfibril binding(GO:0050436)
0.5 22.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.8 11.0 GO:0038191 neuropilin binding(GO:0038191)
2.6 7.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3 7.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.8 7.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 6.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 6.8 GO:0003682 chromatin binding(GO:0003682)
0.5 6.3 GO:0015643 toxic substance binding(GO:0015643)
0.1 5.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 5.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 5.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 5.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.9 4.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 4.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 4.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 4.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 3.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 6.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 6.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.8 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.7 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 8.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 7.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 7.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 5.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 5.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.5 4.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 4.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 4.0 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.2 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex