Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.868

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arxmm10_v2_chrX_+_93286499_93286522-0.387.5e-04Click!
Otpmm10_v2_chr13_+_94875600_948756110.234.1e-02Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 20.332 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_-_67113909 14.106 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_+_65620829 14.032 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr9_+_53771499 10.953 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_-_102906046 9.555 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621669 8.105 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 8.069 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_+_102589687 7.312 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr6_+_8948608 7.133 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr13_-_102905740 6.638 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_25005895 5.944 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr15_+_16778101 5.940 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr14_+_4198185 5.849 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr19_-_29334646 5.799 ENSMUST00000044143.5
 Rln1
relaxin 1
chr3_+_55461758 5.567 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr5_-_118244861 5.457 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr15_-_64922290 5.153 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr9_+_119063429 4.944 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr14_+_5517172 4.357 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 4.357 ENSMUST00000179659.1
 Gm3317
predicted gene 3317

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 36.5 GO:0019532 oxalate transport(GO:0019532)
0.3 15.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 12.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.6 7.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 7.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
1.1 6.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.6 5.9 GO:0036376 sodium ion export from cell(GO:0036376)
1.4 5.8 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.1 5.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) long-term memory(GO:0007616)
0.1 4.9 GO:0051693 actin filament capping(GO:0051693)
0.1 4.3 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1 4.2 GO:0021591 ventricular system development(GO:0021591)
0.0 4.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.8 3.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 2.7 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 2.7 GO:0006953 acute-phase response(GO:0006953)
0.4 2.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 2.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.2 2.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.2 2.0 GO:0016198 axon choice point recognition(GO:0016198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 15.7 GO:0000139 Golgi membrane(GO:0000139)
0.3 7.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.8 5.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 5.5 GO:0014069 postsynaptic density(GO:0014069)
0.3 5.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 4.2 GO:0005871 kinesin complex(GO:0005871)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 2.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 2.0 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 2.0 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.0 GO:0097228 sperm principal piece(GO:0097228)
0.3 1.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 1.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 1.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.4 1.3 GO:0042585 germinal vesicle(GO:0042585)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 36.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 15.6 GO:0000287 magnesium ion binding(GO:0000287)
3.5 14.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 7.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.0 6.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 6.6 GO:0005179 hormone activity(GO:0005179)
0.6 5.9 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 5.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.9 5.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 4.4 GO:0030165 PDZ domain binding(GO:0030165)
0.1 4.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 4.2 GO:0051015 actin filament binding(GO:0051015)
0.1 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 3.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 2.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 2.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 2.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 5.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 4.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.0 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.4 14.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 7.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 5.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 5.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.1 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 1.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 1.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 1.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.2 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport