Motif ID: Hoxc6

Z-value: 0.358


Transcription factors associated with Hoxc6:

Gene SymbolEntrez IDGene Name
Hoxc6 ENSMUSG00000001661.4 Hoxc6



Activity profile for motif Hoxc6.

activity profile for motif Hoxc6


Sorted Z-values histogram for motif Hoxc6

Sorted Z-values for motif Hoxc6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_17574268 3.313 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_+_5218546 1.910 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 1.414 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr4_+_144893127 1.288 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_-_115846080 1.206 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chrM_+_14138 1.122 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr3_+_66985680 1.087 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_+_61175206 1.064 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr15_-_50889043 1.045 ENSMUST00000183997.1
ENSMUST00000183757.1
Trps1

trichorhinophalangeal syndrome I (human)

chrM_-_14060 0.998 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr10_-_100589205 0.971 ENSMUST00000054471.8
4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr7_+_123123870 0.933 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr3_-_113574242 0.908 ENSMUST00000142505.2
Amy1
amylase 1, salivary
chr11_-_23895208 0.847 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr5_-_110046486 0.831 ENSMUST00000167969.1
Gm17655
predicted gene, 17655
chr3_+_5218589 0.831 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr3_+_151437887 0.809 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr15_-_50889691 0.799 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr15_+_44619551 0.752 ENSMUST00000022964.7
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr9_-_27155418 0.709 ENSMUST00000167074.1
ENSMUST00000034472.8
Jam3

junction adhesion molecule 3

chr11_-_109472611 0.696 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr6_+_128399881 0.678 ENSMUST00000120405.1
Nrip2
nuclear receptor interacting protein 2
chr17_-_35115428 0.674 ENSMUST00000172854.1
ENSMUST00000062657.4
Ly6g5b

lymphocyte antigen 6 complex, locus G5B

chrX_-_94212685 0.656 ENSMUST00000050328.8
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr6_-_65144908 0.625 ENSMUST00000031982.4
Hpgds
hematopoietic prostaglandin D synthase
chr17_-_78985428 0.584 ENSMUST00000118991.1
Prkd3
protein kinase D3
chr3_+_66985700 0.558 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr10_-_53647080 0.556 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr6_+_128399766 0.540 ENSMUST00000001561.5
Nrip2
nuclear receptor interacting protein 2
chrX_-_94212638 0.516 ENSMUST00000113922.1
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr16_-_21995478 0.496 ENSMUST00000074230.4
ENSMUST00000060673.6
Liph

lipase, member H

chr2_-_51149100 0.489 ENSMUST00000154545.1
ENSMUST00000017288.2
Rnd3

Rho family GTPase 3

chr1_-_191907527 0.434 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr19_+_11469353 0.430 ENSMUST00000165310.1
Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chrX_-_143933204 0.426 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr9_-_21760275 0.414 ENSMUST00000098942.4
Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_9976294 0.409 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr3_+_66985647 0.395 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr7_-_19604444 0.338 ENSMUST00000086041.5
Clasrp
CLK4-associating serine/arginine rich protein
chr19_+_26748268 0.282 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr1_-_22315792 0.257 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr19_+_32619997 0.238 ENSMUST00000025833.6
Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr1_-_43827751 0.212 ENSMUST00000128261.1
ENSMUST00000126008.1
ENSMUST00000139451.1
Uxs1


UDP-glucuronate decarboxylase 1


chr7_+_5020376 0.211 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chr3_+_136670076 0.201 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chrM_+_9452 0.196 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_-_58718210 0.195 ENSMUST00000169859.1
Gm17542
predicted gene, 17542
chr5_-_23616528 0.185 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr13_+_93304066 0.148 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr15_+_100154379 0.106 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr8_-_109962127 0.078 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3

MARVEL (membrane-associating) domain containing 3

chr8_-_54724317 0.064 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr4_+_132351768 0.055 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr7_-_24299310 0.000 ENSMUST00000145131.1
Zfp61
zinc finger protein 61

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 1.1 GO:0033762 response to glucagon(GO:0033762)
0.1 0.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.6 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.2 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 0.7 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 1.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.4 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 0.9 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 2.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.8 GO:0006378 mRNA polyadenylation(GO:0006378)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.1 1.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.9 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.2 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.3 3.3 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.8 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus