Motif ID: Hoxc9
Z-value: 0.738
Transcription factors associated with Hoxc9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxc9 | ENSMUSG00000036139.6 | Hoxc9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxc9 | mm10_v2_chr15_+_102977032_102977032 | 0.16 | 1.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.9 | 5.7 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 1.9 | 5.6 | GO:0003219 | atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219) |
| 1.1 | 5.4 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
| 0.7 | 2.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.7 | 2.1 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 0.7 | 7.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.5 | 3.8 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.5 | 4.7 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.5 | 5.5 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.4 | 1.7 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 0.4 | 2.9 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.3 | 1.0 | GO:1902527 | positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527) |
| 0.3 | 7.6 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.2 | 1.0 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.2 | 11.1 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.2 | 4.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.2 | 2.8 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 0.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.9 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.1 | 5.0 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.1 | 1.3 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
| 0.1 | 3.2 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 2.6 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
| 0.1 | 1.6 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 2.2 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 1.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 2.0 | GO:0001658 | branching involved in ureteric bud morphogenesis(GO:0001658) |
| 0.0 | 5.1 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 1.1 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 0.2 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.0 | 0.5 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.1 | 5.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.7 | 2.1 | GO:0071914 | prominosome(GO:0071914) |
| 0.6 | 2.8 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.5 | 5.4 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.4 | 1.7 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.4 | 5.0 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 0.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 3.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 1.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.3 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.6 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 4.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 4.7 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.7 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 1.2 | 4.7 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 1.0 | 7.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.7 | 2.1 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.6 | 3.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.6 | 2.8 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.4 | 1.3 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.3 | 4.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.3 | 1.0 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.3 | 1.0 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.2 | 1.7 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 0.9 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 5.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 5.6 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.6 | GO:0097493 | muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 0.3 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 11.1 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 1.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.1 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 1.6 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 1.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.2 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 2.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 1.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 5.4 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 7.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 5.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.3 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 6.7 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.0 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 7.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 2.8 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 8.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 3.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.0 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.5 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
