Motif ID: Hoxd1

Z-value: 0.754


Transcription factors associated with Hoxd1:

Gene SymbolEntrez IDGene Name
Hoxd1 ENSMUSG00000042448.4 Hoxd1



Activity profile for motif Hoxd1.

activity profile for motif Hoxd1


Sorted Z-values histogram for motif Hoxd1

Sorted Z-values for motif Hoxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd1

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chrM_+_10167 4.912 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr17_-_45659312 4.623 ENSMUST00000120717.1
 Capn11
calpain 11
chr2_+_116067213 4.336 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_-_20943413 4.239 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr2_+_150323702 3.839 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr5_-_62766153 3.780 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_119047129 3.602 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr3_-_85722474 3.601 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chrM_+_9870 3.474 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_+_139454747 3.464 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr2_+_119047116 3.398 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_-_116067391 3.206 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr12_-_55014329 3.121 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr2_+_3424123 3.056 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
 Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr2_-_177267036 3.038 ENSMUST00000108963.1
 Gm14409
predicted gene 14409
chr1_-_24612700 2.948 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr5_+_134932351 2.917 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
 Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr5_+_107497762 2.860 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr17_+_88440711 2.768 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr1_+_65186727 2.732 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.8 4.2 GO:0051684 maintenance of Golgi location(GO:0051684)
1.0 3.8 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.9 3.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 3.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
1.1 3.2 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.4 3.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 3.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.8 3.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 3.0 GO:1902018 regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018)
0.0 2.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.7 GO:0032288 myelin assembly(GO:0032288)
0.1 2.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 2.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 2.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283)
0.0 2.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 2.2 GO:0030035 microspike assembly(GO:0030035)
0.7 2.1 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.5 2.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.4 2.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0070469 respiratory chain(GO:0070469)
0.1 4.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.7 3.5 GO:0036449 microtubule minus-end(GO:0036449)
0.8 3.1 GO:0008623 CHRAC(GO:0008623)
0.3 3.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 3.1 GO:0030426 growth cone(GO:0030426)
0.2 2.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.2 2.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 2.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 2.0 GO:0071439 clathrin complex(GO:0071439)
0.0 1.8 GO:0031519 PcG protein complex(GO:0031519)
0.2 1.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 1.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 1.2 GO:0060187 cell pole(GO:0060187)
0.0 1.2 GO:0005776 autophagosome(GO:0005776)
0.2 1.0 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 4.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
0.5 3.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.3 3.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.5 3.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.8 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.3 2.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 2.6 GO:0005516 calmodulin binding(GO:0005516)
0.6 2.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.3 2.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 2.1 GO:0043495 protein anchor(GO:0043495)
0.0 2.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.8 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.4 PID_BCR_5PATHWAY BCR signaling pathway
0.1 2.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.8 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 5.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 2.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 1.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.5 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.0 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex