Motif ID: Hoxd1
Z-value: 0.754
Transcription factors associated with Hoxd1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd1 | ENSMUSG00000042448.4 | Hoxd1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 1.0 | 3.8 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.9 | 3.5 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.8 | 4.2 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.8 | 3.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.7 | 2.1 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.6 | 1.7 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.5 | 2.1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.4 | 2.1 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
| 0.4 | 1.2 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.4 | 1.5 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.4 | 3.1 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.4 | 1.8 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.4 | 1.8 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.3 | 2.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.3 | 1.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.3 | 1.8 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
| 0.3 | 4.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 0.9 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.3 | 0.8 | GO:0046104 | thymidine metabolic process(GO:0046104) |
| 0.2 | 2.2 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.2 | 3.0 | GO:1902018 | regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018) |
| 0.2 | 1.4 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 1.4 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 0.7 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.2 | 3.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 1.0 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.2 | 0.8 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.2 | 1.4 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.2 | 1.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 1.7 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 0.6 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.1 | 0.7 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.1 | 2.7 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 0.6 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.1 | 1.1 | GO:0036159 | outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159) |
| 0.1 | 1.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 0.5 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 2.7 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 3.5 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 1.0 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 0.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.1 | 1.5 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 0.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.2 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.1 | 1.0 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.1 | 2.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 1.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 1.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.7 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 0.2 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.0 | 0.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.5 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.4 | GO:0032570 | response to progesterone(GO:0032570) |
| 0.0 | 1.9 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 2.8 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 2.3 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.2 | GO:0006689 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 0.7 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 2.4 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283) |
| 0.0 | 0.8 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.0 | 0.4 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.5 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.8 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 2.5 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.4 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.4 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.8 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.0 | 0.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.1 | GO:0008623 | CHRAC(GO:0008623) |
| 0.7 | 3.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.3 | 1.2 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 1.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.3 | 3.1 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.2 | 1.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.2 | 2.0 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.2 | 2.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 1.0 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 2.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.1 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 1.4 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 0.8 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 6.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 0.4 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 0.8 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 4.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 2.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.2 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.9 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 1.8 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.2 | GO:0071014 | post-mRNA release spliceosomal complex(GO:0071014) |
| 0.0 | 1.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 3.1 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.5 | 3.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.5 | 3.2 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.4 | 1.5 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
| 0.3 | 2.7 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.3 | 3.1 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.3 | 8.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 1.4 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
| 0.3 | 0.8 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.3 | 2.1 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 4.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.8 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.2 | 1.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 0.8 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.2 | 0.6 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.2 | 1.0 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.2 | 1.4 | GO:0043559 | insulin binding(GO:0043559) |
| 0.2 | 2.1 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.6 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 1.7 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 1.3 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 2.8 | GO:0005402 | cation:sugar symporter activity(GO:0005402) |
| 0.1 | 1.8 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.8 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 0.4 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 1.4 | GO:0050811 | GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811) |
| 0.1 | 3.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 1.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 0.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 0.2 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.0 | 1.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 2.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 1.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 2.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 1.6 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.8 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 4.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 3.4 | GO:0008017 | microtubule binding(GO:0008017) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 3.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 3.1 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.3 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.4 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.9 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.5 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.3 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 2.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.5 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 7.0 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 4.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 0.5 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 2.1 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.5 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.0 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.8 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.8 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.0 | 5.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.9 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 2.0 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 1.0 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
