Motif ID: Hoxd10

Z-value: 0.391


Transcription factors associated with Hoxd10:

Gene SymbolEntrez IDGene Name
Hoxd10 ENSMUSG00000050368.3 Hoxd10



Activity profile for motif Hoxd10.

activity profile for motif Hoxd10


Sorted Z-values histogram for motif Hoxd10

Sorted Z-values for motif Hoxd10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd10

PNG image of the network

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Top targets:


Showing 1 to 20 of 40 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_27790947 8.874 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr8_-_84773381 5.846 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr3_-_80802789 3.888 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_+_102254993 3.790 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_86084434 3.396 ENSMUST00000107664.2
 Sh3d19
SH3 domain protein D19
chr2_+_65620829 2.872 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr10_+_116177351 2.095 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chrX_-_70365052 2.021 ENSMUST00000101509.2
 Ids
iduronate 2-sulfatase
chr1_-_152625212 1.930 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chrX_+_66653003 1.810 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr17_-_78684262 1.547 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr9_+_104569671 1.485 ENSMUST00000057742.8
 Cpne4
copine IV
chr11_-_110168073 1.412 ENSMUST00000044850.3
 Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr3_+_55461758 1.366 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr15_+_9140527 1.209 ENSMUST00000090380.4
 Lmbrd2
LMBR1 domain containing 2
chr9_-_90255927 1.096 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr2_+_106693185 1.093 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr7_+_96210107 1.010 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr10_+_69534039 0.999 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr17_+_71204647 0.950 ENSMUST00000126681.1
 Lpin2
lipin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 3.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 3.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 2.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 1.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.3 1.0 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 1.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.9 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 0.8 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.8 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 0.6 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 0.5 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.2 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.2 GO:0061010 gall bladder development(GO:0061010)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.8 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 3.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 2.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 1.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 0.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 0.6 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.5 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.0 0.2 GO:0015265 urea channel activity(GO:0015265)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.5 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.9 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters