Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.680

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_84064772 18.224 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 14.436 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 9.565 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_-_154636831 8.419 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_144893077 7.186 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_159737510 6.531 ENSMUST00000111669.3
 Tnr
tenascin R
chr17_+_3397189 6.297 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_+_62419668 5.859 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_-_49757257 5.331 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_-_56969864 4.353 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_-_142661858 4.226 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr1_-_56969827 4.088 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_19103022 3.666 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr18_+_69593361 3.572 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr15_+_25773985 3.439 ENSMUST00000125667.1
 Myo10
myosin X
chr1_-_45503282 3.363 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr17_-_35074485 3.215 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr6_+_80018877 3.074 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr4_+_136143497 3.024 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr1_-_152625212 2.824 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 31.2 GO:0042572 retinol metabolic process(GO:0042572)
1.1 8.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.5 8.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.6 6.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 5.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 5.8 GO:0046677 response to antibiotic(GO:0046677)
0.1 5.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 4.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 3.6 GO:0042118 endothelial cell activation(GO:0042118)
1.1 3.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 3.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 3.1 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 3.0 GO:0030903 notochord development(GO:0030903)
0.7 2.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.6 2.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 2.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 2.5 GO:0001889 liver development(GO:0001889)
0.2 2.4 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.5 2.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 2.3 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 GO:0016235 aggresome(GO:0016235)
0.1 8.9 GO:0000118 histone deacetylase complex(GO:0000118)
2.2 6.5 GO:0072534 perineuronal net(GO:0072534)
0.1 4.3 GO:0016459 myosin complex(GO:0016459)
1.1 3.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 3.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.3 2.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 2.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 2.0 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 2.0 GO:0030496 midbody(GO:0030496)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 31.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 7.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 6.5 GO:0046625 sphingolipid binding(GO:0046625)
0.1 6.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 5.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 4.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.9 3.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)
0.4 3.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 3.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 2.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 2.5 GO:0045545 syndecan binding(GO:0045545)
0.0 2.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 2.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.7 2.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 2.0 GO:0032564 dATP binding(GO:0032564)
0.5 1.8 GO:0008061 chitin binding(GO:0008061)
0.1 1.7 GO:0071837 HMG box domain binding(GO:0071837)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 8.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.7 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 5.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.6 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 1.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.2 1.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 6.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 4.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.9 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.8 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events