Motif ID: Hoxd11_Cdx1_Hoxc11
Z-value: 0.680
Transcription factors associated with Hoxd11_Cdx1_Hoxc11:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cdx1 | ENSMUSG00000024619.8 | Cdx1 |
| Hoxc11 | ENSMUSG00000001656.3 | Hoxc11 |
| Hoxd11 | ENSMUSG00000042499.12 | Hoxd11 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 31.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.6 | 6.5 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.1 | 3.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.1 | 8.4 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.7 | 2.8 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.6 | 2.5 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.5 | 4.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.5 | 8.4 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.5 | 2.1 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.5 | 2.3 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.4 | 1.2 | GO:1903054 | negative regulation of extracellular matrix organization(GO:1903054) |
| 0.4 | 2.5 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.3 | 3.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.3 | 2.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.3 | 5.9 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.3 | 0.8 | GO:0061349 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) |
| 0.3 | 1.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.3 | 0.8 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 0.3 | 1.3 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 1.2 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.2 | 1.2 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.2 | 0.9 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.2 | 0.9 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 0.6 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 2.4 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.2 | 0.7 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.2 | 0.5 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.2 | 3.1 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.2 | 0.6 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.2 | 1.7 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 1.5 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.1 | 1.8 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.1 | 5.8 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 3.0 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 0.7 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 2.0 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 1.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 2.0 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 0.3 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.1 | 3.2 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.1 | 0.6 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 1.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.9 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.1 | 0.3 | GO:0045410 | positive regulation of interleukin-6 biosynthetic process(GO:0045410) |
| 0.1 | 1.5 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) |
| 0.1 | 0.3 | GO:0009838 | abscission(GO:0009838) |
| 0.1 | 1.6 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 1.0 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.1 | 0.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.5 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 1.0 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 5.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.3 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.6 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.1 | 0.7 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.5 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.1 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.1 | 0.3 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.0 | 0.3 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 0.9 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.0 | 0.9 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.1 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.0 | 0.2 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 1.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.4 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.4 | GO:0015838 | proline transport(GO:0015824) amino-acid betaine transport(GO:0015838) |
| 0.0 | 0.7 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.0 | 0.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.4 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.5 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.6 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.1 | GO:1905245 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of endocytic recycling(GO:2001137) |
| 0.0 | 0.2 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.2 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.0 | 0.2 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.0 | 0.2 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.0 | 2.5 | GO:0001889 | liver development(GO:0001889) |
| 0.0 | 0.5 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 0.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.8 | GO:0014742 | positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742) |
| 0.0 | 0.7 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.0 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.0 | 1.0 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 0.3 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 0.1 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.0 | 0.6 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.1 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.0 | 0.2 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 1.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.3 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.1 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.0 | 2.3 | GO:0043524 | negative regulation of neuron apoptotic process(GO:0043524) |
| 0.0 | 0.5 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 1.4 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 0.1 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 0.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.3 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 0.5 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.1 | 3.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.4 | 2.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.4 | 2.0 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.3 | 2.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 0.9 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.2 | 8.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 1.0 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.2 | 2.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 1.7 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 2.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.6 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 1.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 8.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 2.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 3.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 0.3 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 4.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 0.5 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 1.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.6 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 1.9 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.6 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 2.0 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 1.2 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 2.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 3.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 2.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 31.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.9 | 3.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.7 | 2.0 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.5 | 1.4 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.5 | 1.8 | GO:0008061 | chitin binding(GO:0008061) |
| 0.4 | 2.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.4 | 2.5 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.4 | 1.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 6.5 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.4 | 1.5 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.4 | 3.2 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.3 | 1.6 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.3 | 1.3 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.3 | 0.8 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.3 | 0.8 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.2 | 1.2 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.2 | 2.0 | GO:0032564 | dATP binding(GO:0032564) |
| 0.2 | 2.2 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.2 | 0.6 | GO:0002134 | UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 0.2 | 5.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 1.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 0.5 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.2 | 0.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 0.5 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.2 | 4.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 3.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 0.5 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.1 | 4.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.5 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.1 | 7.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 0.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 3.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.1 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.1 | 6.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 0.3 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 1.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.0 | 0.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.0 | 0.9 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.6 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 3.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 2.4 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.9 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.3 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 1.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.2 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.0 | 1.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.7 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.1 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.6 | GO:0043015 | cAMP binding(GO:0030552) gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.3 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.1 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.1 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 5.5 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 1.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 7.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.3 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 4.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 6.3 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.6 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 0.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 8.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.2 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.1 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.0 | 1.6 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 1.2 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.1 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.5 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.2 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 7.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.0 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 1.5 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.4 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 3.6 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.0 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 6.3 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 0.9 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.8 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.1 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.8 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 2.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.6 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.6 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.5 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.3 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.0 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.3 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.3 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
|
|
|