Motif ID: Hoxd12

Z-value: 1.314


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_84064772 36.917 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr1_-_56969864 26.653 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr15_-_8710734 25.966 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_144893127 24.436 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 23.777 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr15_-_8710409 21.237 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_56969827 20.380 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr4_-_154636831 19.791 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr4_+_144893077 18.151 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_159737510 15.715 ENSMUST00000111669.3
Tnr
tenascin R
chr16_+_42907563 15.212 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr1_+_19103022 11.267 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr9_-_77347816 10.635 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr9_-_77347787 9.015 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr5_-_62766153 7.916 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_9403049 7.617 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr1_-_45503282 7.562 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr6_+_125215551 7.540 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr17_+_3397189 7.431 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_101692624 7.236 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr1_-_152625212 6.988 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr4_-_88033328 6.624 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr9_-_77347889 6.272 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr19_-_6987621 5.731 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb

vascular endothelial growth factor B

chr18_-_35215008 5.629 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr17_+_57358682 5.491 ENSMUST00000086763.5
ENSMUST00000004850.7
Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr19_+_55741810 5.416 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_+_73271925 4.560 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr13_-_97747373 4.509 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_165934900 4.467 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr13_-_97747399 4.084 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_-_87768932 3.890 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
Pear1




platelet endothelial aggregation receptor 1




chr18_-_20002093 3.829 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr11_-_118355496 3.803 ENSMUST00000017610.3
Timp2
tissue inhibitor of metalloproteinase 2
chr5_+_19907502 3.744 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_66985680 3.728 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_30655859 3.714 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr2_-_36104060 3.647 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr5_+_107497762 3.609 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr11_-_109473220 3.503 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr15_+_81936753 3.484 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr9_+_62858085 3.415 ENSMUST00000034777.6
ENSMUST00000163820.1
Calml4

calmodulin-like 4

chr3_+_122419772 3.315 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr5_+_107497718 3.223 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr5_-_62765618 3.123 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_90071095 3.115 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_-_35897073 3.076 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik



RIKEN cDNA 2310061I04 gene



chr1_+_81077204 3.028 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr1_+_81077274 2.921 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr19_-_45812291 2.807 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr19_+_60755947 2.768 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr12_+_55836365 2.731 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr4_+_136284708 2.675 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr6_+_15185203 2.660 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr7_-_100583072 2.656 ENSMUST00000152876.1
ENSMUST00000150042.1
Mrpl48

mitochondrial ribosomal protein L48

chr1_-_163313661 2.613 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr2_-_45117349 2.584 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr13_+_80883403 2.532 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr10_+_116177351 2.506 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr4_+_136284658 2.491 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr8_+_25720054 2.446 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr8_+_69902178 2.432 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr6_-_119388671 2.423 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chrX_+_56779437 2.414 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr3_+_66985647 2.412 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr17_-_91092715 2.324 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr13_-_56895737 2.167 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr16_-_35769356 2.153 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr1_+_63176818 2.135 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chrX_+_140456613 2.126 ENSMUST00000033809.3
Prps1
phosphoribosyl pyrophosphate synthetase 1
chr4_-_11981265 2.095 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr17_-_51826562 2.092 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr3_+_66985700 2.075 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_66985947 2.055 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr4_+_31964081 2.012 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7



mitogen-activated protein kinase kinase kinase 7



chr3_+_41024369 1.898 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr4_-_82505749 1.883 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr14_-_118052235 1.822 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr11_-_109472611 1.798 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr16_+_11405648 1.770 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr14_+_66868850 1.694 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr15_+_81936911 1.690 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr3_-_126998408 1.680 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr7_+_81213567 1.469 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chr13_-_18382041 1.446 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr5_-_24030649 1.423 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr3_-_141931523 1.405 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr4_-_82505707 1.399 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr5_-_74531619 1.366 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr5_-_24842579 1.356 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr9_-_13245741 1.336 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr8_-_47352348 1.284 ENSMUST00000110367.2
Stox2
storkhead box 2
chr18_-_37020679 1.233 ENSMUST00000097612.2
Gm10545
predicted gene 10545
chr18_-_15063560 0.997 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr4_+_148000722 0.968 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr17_+_91236787 0.954 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr1_+_153874335 0.875 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr17_+_73804841 0.830 ENSMUST00000024860.7
Ehd3
EH-domain containing 3
chr13_-_99344652 0.792 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr1_+_164048214 0.778 ENSMUST00000027874.5
Sele
selectin, endothelial cell
chr1_-_44118757 0.758 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1

KDEL (Lys-Asp-Glu-Leu) containing 1

chr8_-_69902558 0.738 ENSMUST00000110167.3
Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr3_+_108591279 0.736 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr2_-_66410064 0.726 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chrM_+_3906 0.557 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr12_+_33147754 0.534 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1

ataxin 7-like 1

chr14_+_32085804 0.525 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr14_-_36919513 0.498 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr1_-_128102412 0.462 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr3_-_19163011 0.432 ENSMUST00000029125.8
Armc1
armadillo repeat containing 1
chr14_-_36919314 0.349 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr14_-_66868572 0.310 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr12_-_73047179 0.181 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr13_-_23622502 0.161 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr1_-_63176653 0.124 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr18_-_3281712 0.112 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 47.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
6.0 66.4 GO:0042572 retinol metabolic process(GO:0042572)
3.9 15.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.9 45.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.5 7.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
2.5 19.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.4 5.7 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.8 2.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.8 3.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.8 6.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 3.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.7 7.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.7 2.1 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.7 2.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.7 5.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 4.6 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.6 3.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.6 3.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.6 25.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.6 2.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.5 2.4 GO:0061042 vascular wound healing(GO:0061042)
0.4 2.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 6.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 2.0 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.4 7.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.4 3.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.4 15.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 1.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 2.4 GO:0035092 sperm chromatin condensation(GO:0035092)
0.3 1.8 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 10.3 GO:0046677 response to antibiotic(GO:0046677)
0.3 3.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 1.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.2 5.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 1.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.2 0.5 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 2.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 2.8 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 2.6 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 0.8 GO:1901387 Golgi to lysosome transport(GO:0090160) positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 3.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 2.2 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.5 GO:1901032 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.1 0.8 GO:0006664 glycolipid metabolic process(GO:0006664) liposaccharide metabolic process(GO:1903509)
0.1 2.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 5.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 0.8 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 11.3 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.1 1.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 5.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.1 GO:0006414 translational elongation(GO:0006414)
0.0 2.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.3 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.2 GO:0098532 nucleosome positioning(GO:0016584) histone H3-K27 trimethylation(GO:0098532)
0.0 2.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.8 GO:0048747 muscle fiber development(GO:0048747)
0.0 1.0 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0072534 perineuronal net(GO:0072534)
2.5 7.6 GO:0005588 collagen type V trimer(GO:0005588)
1.5 7.5 GO:0070820 tertiary granule(GO:0070820)
0.7 6.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 5.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.5 2.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.5 49.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 19.8 GO:0016235 aggresome(GO:0016235)
0.4 2.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 7.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.3 3.8 GO:0030057 desmosome(GO:0030057)
0.3 0.8 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.3 28.0 GO:0016605 PML body(GO:0016605)
0.3 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 47.2 GO:0043197 dendritic spine(GO:0043197)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 6.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 1.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.7 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 6.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 5.7 GO:0016020 membrane(GO:0016020)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.8 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 66.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
7.9 47.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.9 5.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
1.8 7.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
1.2 7.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.9 15.7 GO:0046625 sphingolipid binding(GO:0046625)
0.6 3.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 2.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.6 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 2.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 2.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.4 9.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 5.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 29.8 GO:0046332 SMAD binding(GO:0046332)
0.2 11.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 4.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 7.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 2.6 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.1 5.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 12.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.5 GO:0031690 adrenergic receptor binding(GO:0031690)
0.1 2.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 3.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 5.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 7.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 37.6 GO:0003682 chromatin binding(GO:0003682)
0.1 0.5 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.4 GO:0019003 GDP binding(GO:0019003)
0.0 2.1 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 0.2 GO:0032564 dATP binding(GO:0032564)
0.0 7.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.7 GO:0044325 ion channel binding(GO:0044325)
0.0 1.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.4 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 61.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 5.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.4 7.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.3 11.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 7.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 2.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 7.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 15.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 6.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 47.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 7.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.6 7.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.5 5.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 2.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.0 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 7.7 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 7.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 8.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.1 REACTOME_TRANSLATION Genes involved in Translation
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation