Motif ID: Hoxd12

Z-value: 1.314


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_84064772 36.917 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr1_-_56969864 26.653 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_-_8710734 25.966 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_144893127 24.436 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 23.777 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr15_-_8710409 21.237 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_56969827 20.380 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_154636831 19.791 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_144893077 18.151 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_159737510 15.715 ENSMUST00000111669.3
 Tnr
tenascin R
chr16_+_42907563 15.212 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr1_+_19103022 11.267 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr9_-_77347816 10.635 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 9.015 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr5_-_62766153 7.916 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_9403049 7.617 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr1_-_45503282 7.562 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr6_+_125215551 7.540 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
 Vamp1


vesicle-associated membrane protein 1


chr17_+_3397189 7.431 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_101692624 7.236 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.0 66.4 GO:0042572 retinol metabolic process(GO:0042572)
11.8 47.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.9 45.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 25.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.5 19.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
3.9 15.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 15.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 11.3 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.3 10.3 GO:0046677 response to antibiotic(GO:0046677)
2.5 7.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 7.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.7 7.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.4 6.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.8 6.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
1.4 5.7 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.2 5.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.7 5.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 5.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 5.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.7 4.6 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 49.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 47.2 GO:0043197 dendritic spine(GO:0043197)
0.3 28.0 GO:0016605 PML body(GO:0016605)
0.4 19.8 GO:0016235 aggresome(GO:0016235)
5.2 15.7 GO:0072534 perineuronal net(GO:0072534)
2.5 7.6 GO:0005588 collagen type V trimer(GO:0005588)
1.5 7.5 GO:0070820 tertiary granule(GO:0070820)
0.3 7.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 6.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 6.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 6.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 5.7 GO:0016020 membrane(GO:0016020)
0.6 5.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.3 3.8 GO:0030057 desmosome(GO:0030057)
0.3 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.5 2.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.5 66.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
7.9 47.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 37.6 GO:0003682 chromatin binding(GO:0003682)
0.2 29.8 GO:0046332 SMAD binding(GO:0046332)
0.9 15.7 GO:0046625 sphingolipid binding(GO:0046625)
0.1 12.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 11.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 9.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 7.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 7.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 7.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.8 7.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
1.2 7.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.9 5.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.3 5.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 5.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 5.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 4.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 3.7 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 61.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 15.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 11.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 7.6 NABA_COLLAGENS Genes encoding collagen proteins
0.2 7.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 7.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.4 7.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 6.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.5 5.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 3.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 2.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.8 PID_TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 47.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 8.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 7.7 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 7.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 7.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 7.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.5 5.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 2.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 2.1 REACTOME_TRANSLATION Genes involved in Translation
0.2 2.0 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 2.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 1.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling