Motif ID: Hoxd8
Z-value: 0.896
Transcription factors associated with Hoxd8:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd8 | ENSMUSG00000027102.4 | Hoxd8 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 20.8 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 2.8 | 8.5 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 2.5 | 7.4 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 1.9 | 7.8 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 1.6 | 21.9 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 1.3 | 6.4 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 1.2 | 4.8 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 1.2 | 9.5 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 0.9 | 5.3 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.8 | 3.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 2.7 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.5 | 2.3 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.4 | 1.3 | GO:1905034 | regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035) |
| 0.4 | 1.8 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
| 0.3 | 0.9 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.3 | 1.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.2 | 0.7 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.2 | 0.8 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 1.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 1.2 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 2.1 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 2.5 | GO:2000780 | negative regulation of double-strand break repair(GO:2000780) |
| 0.1 | 1.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 6.9 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
| 0.1 | 11.2 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.1 | 0.6 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 0.1 | 5.2 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.1 | 0.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.4 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 4.4 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
| 0.0 | 1.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 4.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.1 | GO:0072092 | ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093) |
| 0.0 | 2.9 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.0 | 0.1 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 0.5 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 5.8 | GO:0007265 | Ras protein signal transduction(GO:0007265) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.4 | GO:0060187 | cell pole(GO:0060187) |
| 1.5 | 4.4 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
| 0.8 | 21.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.5 | 2.1 | GO:0045251 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
| 0.1 | 0.7 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.1 | 2.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 2.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 6.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 0.8 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.6 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 5.2 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 5.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 4.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.1 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 3.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 9.3 | GO:0016604 | nuclear body(GO:0016604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.5 | GO:0008142 | oxysterol binding(GO:0008142) |
| 2.3 | 6.9 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 2.1 | 8.5 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 1.7 | 8.3 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 1.6 | 7.8 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.9 | 4.4 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132) |
| 0.5 | 6.4 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.3 | 2.0 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.2 | 11.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 5.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 2.7 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.2 | 21.6 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 3.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.9 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.1 | 1.8 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.1 | 2.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 1.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 0.7 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 3.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 5.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 4.6 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 2.1 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.0 | 2.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.5 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 5.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.0 | 7.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 4.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.2 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 6.4 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 4.4 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 6.4 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 5.7 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 3.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 2.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 2.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.6 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.8 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 21.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 5.7 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.3 | 4.4 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 2.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 4.8 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 2.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 0.8 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 6.4 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 4.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.9 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.5 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.4 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 2.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.2 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 3.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.0 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
