Motif ID: Hsf2

Z-value: 1.339


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_574864140.569.5e-08Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 16.643 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_-_138847579 12.740 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr1_+_136467958 10.792 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr1_+_138963709 10.716 ENSMUST00000168527.1
 Dennd1b
DENN/MADD domain containing 1B
chr13_+_51645232 10.536 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr4_-_53159885 10.341 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_4752972 10.275 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr11_-_11970540 9.663 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr17_-_70849644 9.630 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr8_-_110168204 9.611 ENSMUST00000003754.6
 Calb2
calbindin 2
chr15_+_57694651 9.352 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr17_-_70851189 9.064 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr4_+_128883549 9.017 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr17_-_34972124 8.675 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr5_+_135887988 8.653 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr3_+_94342092 8.612 ENSMUST00000029794.5
 Them5
thioesterase superfamily member 5
chr10_-_92165159 8.583 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr5_+_135887905 8.444 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr5_+_17574726 8.440 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_+_92683625 8.352 ENSMUST00000168878.1
 Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 23.6 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
1.4 21.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.0 17.8 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
2.7 16.3 GO:0003350 pulmonary myocardium development(GO:0003350)
3.9 15.4 GO:0021698 cerebellar cortex structural organization(GO:0021698)
2.2 15.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
4.7 14.0 GO:0030421 defecation(GO:0030421)
2.8 13.9 GO:0003213 cardiac right atrium morphogenesis(GO:0003213)
2.5 12.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.5 12.0 GO:0046596 regulation of viral entry into host cell(GO:0046596)
1.6 11.1 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
2.6 10.3 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.2 9.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.1 9.7 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 9.6 GO:0032048 cardiolipin metabolic process(GO:0032048)
1.0 9.3 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 7.9 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
1.9 7.8 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.5 7.6 GO:0034421 post-translational protein acetylation(GO:0034421)
1.9 7.5 GO:0060032 notochord regression(GO:0060032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.9 GO:0016459 myosin complex(GO:0016459)
2.8 17.1 GO:0097512 cardiac myofibril(GO:0097512)
2.0 15.8 GO:0005818 aster(GO:0005818)
0.0 15.7 GO:0016607 nuclear speck(GO:0016607)
0.1 15.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.0 15.1 GO:0045180 basal cortex(GO:0045180)
0.6 11.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 10.8 GO:0051233 spindle midzone(GO:0051233)
0.2 10.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 10.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.3 9.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.2 8.2 GO:0016235 aggresome(GO:0016235)
0.3 8.0 GO:0005921 gap junction(GO:0005921)
0.7 7.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.3 6.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 6.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 6.0 GO:0030061 mitochondrial crista(GO:0030061)
1.9 5.8 GO:0042585 germinal vesicle(GO:0042585)
0.1 5.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 5.7 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 21.6 GO:0070410 co-SMAD binding(GO:0070410)
0.3 16.9 GO:0001784 phosphotyrosine binding(GO:0001784)
1.3 16.3 GO:0038191 neuropilin binding(GO:0038191)
1.8 15.8 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.4 14.2 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.3 12.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 10.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
2.6 10.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
3.4 10.3 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
1.2 9.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.5 9.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 8.9 GO:0003774 motor activity(GO:0003774)
0.1 8.3 GO:0008201 heparin binding(GO:0008201)
1.3 7.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.5 7.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.8 7.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 7.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 7.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 6.6 GO:0005112 Notch binding(GO:0005112)
0.1 6.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 25.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.6 22.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 21.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 17.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 13.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 12.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 11.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 11.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.4 10.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 9.7 PID_IGF1_PATHWAY IGF1 pathway
0.4 7.8 ST_STAT3_PATHWAY STAT3 Pathway
0.3 7.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 6.8 PID_ATM_PATHWAY ATM pathway
0.3 5.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 5.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 5.1 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.2 4.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 3.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 3.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 22.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 21.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.5 18.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 13.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.8 10.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 9.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 9.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.7 9.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 8.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 7.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 7.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 6.9 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.6 6.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 5.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 5.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 5.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 5.1 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.2 4.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.2 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 4.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation