Motif ID: Hsfy2

Z-value: 1.215


Transcription factors associated with Hsfy2:

Gene SymbolEntrez IDGene Name
Hsfy2 ENSMUSG00000045336.4 Hsfy2



Activity profile for motif Hsfy2.

activity profile for motif Hsfy2


Sorted Z-values histogram for motif Hsfy2

Sorted Z-values for motif Hsfy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsfy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152847993 19.290 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr14_-_67715585 18.544 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr2_+_152847961 17.352 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr1_-_98095596 14.336 ENSMUST00000058762.8
ENSMUST00000097625.3
 Pam

peptidylglycine alpha-amidating monooxygenase

chr15_+_57694651 13.949 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr11_-_102925086 13.938 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr11_-_84068766 13.767 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr8_-_53638945 13.107 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr13_+_51645232 11.849 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr1_+_139454747 11.441 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr1_+_74391479 10.784 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr15_-_32244632 9.955 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_+_45627709 8.741 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr6_+_56017489 8.524 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr9_-_72491939 7.908 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
 Tex9




testis expressed gene 9




chr6_-_48840988 7.717 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr17_+_50698525 7.630 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr6_+_134929118 7.591 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr3_+_107896247 7.435 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr13_-_64153194 7.224 ENSMUST00000059817.4
ENSMUST00000117241.1
 Zfp367

zinc finger protein 367


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 42.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.3 21.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 18.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 18.5 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
2.1 14.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 14.4 GO:0035019 somatic stem cell population maintenance(GO:0035019)
1.2 14.3 GO:0009404 toxin metabolic process(GO:0009404)
1.1 13.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.4 13.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 13.1 GO:0006284 base-excision repair(GO:0006284)
1.2 12.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 11.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 11.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 11.2 GO:0010921 regulation of phosphatase activity(GO:0010921)
2.1 10.4 GO:0051661 maintenance of centrosome location(GO:0051661)
2.5 10.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.2 8.7 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.4 7.9 GO:0003334 keratinocyte development(GO:0003334)
1.1 7.4 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 7.1 GO:0008380 RNA splicing(GO:0008380)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.3 50.6 GO:0005818 aster(GO:0005818)
0.0 21.7 GO:0005694 chromosome(GO:0005694)
0.0 15.6 GO:0005929 cilium(GO:0005929)
0.2 14.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 12.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 11.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.9 11.4 GO:0036449 microtubule minus-end(GO:0036449)
0.8 11.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 7.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 7.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 7.2 GO:0016605 PML body(GO:0016605)
1.7 7.0 GO:0008623 CHRAC(GO:0008623)
0.1 6.9 GO:0044295 axonal growth cone(GO:0044295)
2.0 6.0 GO:1990423 RZZ complex(GO:1990423)
0.1 6.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 5.6 GO:0070469 respiratory chain(GO:0070469)
0.0 5.5 GO:0030027 lamellipodium(GO:0030027)
0.1 5.3 GO:0005871 kinesin complex(GO:0005871)
1.2 4.8 GO:0005594 collagen type IX trimer(GO:0005594)
0.8 4.8 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 36.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 16.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 14.5 GO:0008013 beta-catenin binding(GO:0008013)
4.8 14.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 14.0 GO:0003714 transcription corepressor activity(GO:0003714)
1.5 13.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 13.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
2.6 13.1 GO:0000405 bubble DNA binding(GO:0000405)
2.0 12.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
3.0 11.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 11.6 GO:0005516 calmodulin binding(GO:0005516)
1.2 10.8 GO:0008420 CTD phosphatase activity(GO:0008420)
2.0 10.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
1.1 8.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 7.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.7 6.9 GO:0004064 arylesterase activity(GO:0004064)
0.9 6.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 6.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 5.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 5.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 36.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 13.7 PID_ATR_PATHWAY ATR signaling pathway
0.4 10.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 10.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 8.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 8.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 4.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 4.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 4.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 3.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.8 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 7.6 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.3 7.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.6 5.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.8 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 5.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 4.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 3.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 3.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 3.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 3.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 3.0 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.6 2.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 2.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism