Motif ID: Id4

Z-value: 1.055


Transcription factors associated with Id4:

Gene SymbolEntrez IDGene Name
Id4 ENSMUSG00000021379.1 Id4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Id4mm10_v2_chr13_+_48261427_48261427-0.084.6e-01Click!


Activity profile for motif Id4.

activity profile for motif Id4


Sorted Z-values histogram for motif Id4

Sorted Z-values for motif Id4



Network of associatons between targets according to the STRING database.



First level regulatory network of Id4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 18.828 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_-_67922136 17.144 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr11_+_42419729 14.239 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr12_+_82616885 12.901 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr3_-_82145865 12.433 ENSMUST00000048976.6
 Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr13_+_83504032 10.814 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_+_54571358 10.052 ENSMUST00000025356.2
 Mal2
mal, T cell differentiation protein 2
chr4_+_125490688 9.135 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr15_-_98677451 8.736 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr7_+_123982799 8.663 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr15_-_60824942 7.975 ENSMUST00000100635.3
 Fam84b
family with sequence similarity 84, member B
chr14_-_39472825 7.622 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr13_-_57907587 7.582 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_104367549 7.504 ENSMUST00000106830.2
 Dab1
disabled 1
chr15_-_71727815 7.402 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr14_-_121797670 7.245 ENSMUST00000100299.3
 Dock9
dedicator of cytokinesis 9
chr1_-_180483410 7.168 ENSMUST00000136521.1
ENSMUST00000179826.1
 6330403A02Rik

RIKEN cDNA 6330403A02 gene

chr5_+_98854434 7.157 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr19_-_57314896 7.152 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr11_+_7063423 6.989 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 329 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.2 GO:0034605 cellular response to heat(GO:0034605)
0.1 21.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.3 17.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 16.3 GO:0016579 protein deubiquitination(GO:0016579)
1.6 14.2 GO:0071420 cellular response to histamine(GO:0071420)
0.3 12.9 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.2 12.9 GO:0030032 lamellipodium assembly(GO:0030032)
2.5 12.4 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
2.5 12.4 GO:0042636 negative regulation of hair cycle(GO:0042636) negative regulation of hair follicle development(GO:0051799)
1.7 12.0 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
3.6 10.8 GO:0007521 muscle cell fate determination(GO:0007521) positive regulation of macrophage apoptotic process(GO:2000111)
0.7 10.5 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.4 9.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 9.7 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)
1.0 9.5 GO:0046959 habituation(GO:0046959)
0.9 9.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.3 9.1 GO:0061157 mRNA destabilization(GO:0061157)
2.9 8.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.4 8.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.3 8.4 GO:0043496 regulation of protein homodimerization activity(GO:0043496)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 36.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.1 21.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 19.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.9 14.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 13.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 11.3 GO:0005813 centrosome(GO:0005813)
0.1 11.1 GO:0070382 exocytic vesicle(GO:0070382)
0.2 9.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
1.6 9.4 GO:0045179 apical cortex(GO:0045179)
0.4 9.4 GO:0032590 dendrite membrane(GO:0032590)
1.3 9.2 GO:0070695 FHF complex(GO:0070695)
0.1 9.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 9.1 GO:1990635 proximal dendrite(GO:1990635)
0.3 9.0 GO:0033268 node of Ranvier(GO:0033268)
0.5 8.9 GO:0032279 asymmetric synapse(GO:0032279)
0.3 8.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 8.1 GO:0090544 BAF-type complex(GO:0090544)
2.7 8.0 GO:0043512 inhibin A complex(GO:0043512)
0.0 7.4 GO:0030425 dendrite(GO:0030425)
1.5 7.3 GO:1990761 growth cone lamellipodium(GO:1990761)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 26.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.0 24.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 17.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
3.6 14.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 14.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 13.9 GO:0005096 GTPase activator activity(GO:0005096)
0.3 13.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 13.0 GO:0003779 actin binding(GO:0003779)
0.1 12.9 GO:0003924 GTPase activity(GO:0003924)
0.4 11.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.7 11.2 GO:0045499 chemorepellent activity(GO:0045499)
1.3 10.5 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 10.5 GO:0005516 calmodulin binding(GO:0005516)
0.4 10.3 GO:0070064 proline-rich region binding(GO:0070064)
0.4 10.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 9.8 GO:0030552 cAMP binding(GO:0030552)
0.5 9.0 GO:0035198 miRNA binding(GO:0035198)
1.7 8.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.0 8.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.7 8.1 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 15.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.2 15.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 13.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.7 12.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 11.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 10.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 10.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 9.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 7.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 6.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 6.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 6.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 6.0 PID_ALK1_PATHWAY ALK1 signaling events
0.1 5.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 4.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 4.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.9 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.0 15.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 14.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.8 13.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.0 12.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.8 11.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.4 9.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 9.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 9.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 8.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 8.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
2.0 8.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 7.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 7.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 7.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 7.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 6.1 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 5.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 5.8 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.2 5.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets