Motif ID: Ikzf2
Z-value: 0.929
Transcription factors associated with Ikzf2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Ikzf2 | ENSMUSG00000025997.7 | Ikzf2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ikzf2 | mm10_v2_chr1_-_69685937_69685966 | 0.27 | 1.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 4.5 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 1.2 | 6.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.0 | 2.9 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.7 | 4.1 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.6 | 1.7 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.4 | 1.3 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.4 | 1.2 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.4 | 1.1 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.3 | 2.2 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.3 | 3.9 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.3 | 0.9 | GO:0072284 | cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 0.3 | 1.4 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.3 | 1.3 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504) |
| 0.2 | 1.5 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.2 | 2.7 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 2.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.2 | 2.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 1.1 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.2 | 0.7 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.2 | 1.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 1.9 | GO:0031441 | negative regulation of mRNA 3'-end processing(GO:0031441) |
| 0.2 | 1.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.9 | GO:0036394 | amylase secretion(GO:0036394) |
| 0.1 | 0.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.9 | GO:0060312 | regulation of blood vessel remodeling(GO:0060312) |
| 0.1 | 1.0 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.9 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 1.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 0.4 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.1 | 3.7 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.1 | 1.0 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.1 | 0.4 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 0.9 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 3.7 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 1.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.9 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 1.6 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 0.2 | GO:0006710 | androgen catabolic process(GO:0006710) |
| 0.0 | 0.5 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 1.2 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 2.0 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 1.3 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.0 | 2.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.6 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.0 | 0.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.5 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.1 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.0 | 0.1 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.2 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.0 | 0.9 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.6 | GO:0021884 | forebrain neuron development(GO:0021884) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.9 | 3.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.7 | 6.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.4 | 1.1 | GO:0034679 | integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679) |
| 0.3 | 1.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.3 | 1.5 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 1.3 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.2 | 0.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 1.2 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 1.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.2 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 4.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.6 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 1.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.9 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.2 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 1.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 3.1 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.3 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 2.1 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.1 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.3 | GO:0097440 | apical dendrite(GO:0097440) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.7 | GO:0098634 | protein binding involved in cell-matrix adhesion(GO:0098634) |
| 0.4 | 2.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.4 | 6.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 4.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 1.3 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.3 | 1.0 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 0.7 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.2 | 0.9 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 3.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.1 | 1.8 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 1.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 0.2 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 0.9 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 2.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 3.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 3.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.9 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.1 | 0.5 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.4 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.3 | GO:0004970 | ionotropic glutamate receptor activity(GO:0004970) extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.0 | 1.6 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 0.2 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.0 | 1.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.3 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.1 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.0 | 3.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 2.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 0.9 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 4.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 6.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.4 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.4 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.5 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 2.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 5.2 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 1.6 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.1 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.2 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 1.3 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 0.6 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.7 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.7 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.9 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 3.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.4 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
