Motif ID: Ikzf2

Z-value: 0.929


Transcription factors associated with Ikzf2:

Gene SymbolEntrez IDGene Name
Ikzf2 ENSMUSG00000025997.7 Ikzf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_696859660.271.9e-02Click!


Activity profile for motif Ikzf2.

activity profile for motif Ikzf2


Sorted Z-values histogram for motif Ikzf2

Sorted Z-values for motif Ikzf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ikzf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 24.776 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr15_+_3270767 12.733 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr1_+_45311538 6.127 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_+_4003926 5.206 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr7_-_70360593 4.497 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_-_23248264 4.062 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_75308308 3.943 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr11_-_55419898 3.732 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr5_-_123141067 3.671 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr1_-_45503282 2.913 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_+_88214474 2.866 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chr13_-_103764502 2.365 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr1_-_162866502 2.211 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr19_-_29812952 2.197 ENSMUST00000099525.3
 Ranbp6
RAN binding protein 6
chr5_-_123140135 2.160 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr2_-_77170592 2.042 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr9_+_64385675 1.928 ENSMUST00000068967.4
 Megf11
multiple EGF-like-domains 11
chr8_+_45627709 1.926 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chrX_+_109095359 1.918 ENSMUST00000033598.8
 Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr2_-_66410064 1.774 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 6.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.2 4.5 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.7 4.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 3.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 3.7 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 3.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.0 2.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 2.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 2.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 2.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.2 2.2 GO:0009404 toxin metabolic process(GO:0009404)
0.2 2.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 2.0 GO:0051642 centrosome localization(GO:0051642)
0.2 1.9 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.1 1.9 GO:0010842 retina layer formation(GO:0010842)
0.2 1.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 1.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 1.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 1.6 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.5 GO:0035166 post-embryonic hemopoiesis(GO:0035166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.9 3.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.1 GO:0034399 nuclear periphery(GO:0034399)
1.0 2.9 GO:0005588 collagen type V trimer(GO:0005588)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.1 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.5 GO:0032437 cuticular plate(GO:0032437)
0.3 1.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 1.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 1.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.2 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.4 1.1 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 4.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 3.9 GO:0003924 GTPase activity(GO:0003924)
0.1 3.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
0.5 2.7 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.0 2.4 GO:0051015 actin filament binding(GO:0051015)
0.4 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.8 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.6 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.4 GO:0008143 poly(A) binding(GO:0008143)
0.3 1.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.3 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.3 GO:0004970 ionotropic glutamate receptor activity(GO:0004970) extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 1.3 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 5.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 4.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane