Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.245

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.615.3e-09Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.403.8e-04Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.387.8e-04Click!
Irf2mm10_v2_chr8_+_46739745_467397910.299.8e-03Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.075.7e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 148.535 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 141.362 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3027439 138.333 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 136.227 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 133.510 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 133.258 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3004457 125.736 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr2_-_98667264 123.936 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3000922 121.170 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr14_-_19418930 121.078 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3037111 120.353 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 115.305 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 111.883 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3018753 105.786 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3025417 103.921 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_+_98662227 59.366 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chrX_-_134161928 34.609 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr2_+_122147680 31.557 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr1_-_173942445 28.163 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr4_-_156200818 25.521 ENSMUST00000085425.4
 Isg15
ISG15 ubiquitin-like modifier

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 684.7 GO:0008150 biological_process(GO:0008150)
6.4 128.1 GO:0042832 defense response to protozoan(GO:0042832)
3.4 91.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
13.3 53.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.2 42.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.1 41.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
9.4 37.6 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
3.6 32.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
10.0 30.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.1 29.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
4.5 27.3 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
1.7 26.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
4.1 24.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
3.0 23.6 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
7.5 22.4 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.7 21.9 GO:0071346 cellular response to interferon-gamma(GO:0071346)
2.3 20.6 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
5.9 17.8 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
1.5 17.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.4 16.5 GO:0035456 response to interferon-beta(GO:0035456)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1395.6 GO:0005575 cellular_component(GO:0005575)
9.8 127.8 GO:0020003 symbiont-containing vacuole(GO:0020003)
6.4 76.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 58.3 GO:0009897 external side of plasma membrane(GO:0009897)
2.6 39.0 GO:0044754 autolysosome(GO:0044754)
0.2 23.1 GO:0016605 PML body(GO:0016605)
1.3 20.4 GO:0005614 interstitial matrix(GO:0005614)
3.6 17.9 GO:1990462 omegasome(GO:1990462)
1.6 14.2 GO:0030478 actin cap(GO:0030478)
2.0 14.1 GO:0042825 TAP complex(GO:0042825)
1.5 13.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
2.9 11.6 GO:0061702 inflammasome complex(GO:0061702)
0.2 11.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.4 10.8 GO:0042611 MHC protein complex(GO:0042611)
0.1 10.3 GO:0031519 PcG protein complex(GO:0031519)
3.4 10.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.6 9.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.7 9.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.1 8.6 GO:0033269 internode region of axon(GO:0033269)
0.6 7.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1000.3 GO:0003674 molecular_function(GO:0003674)
0.6 178.6 GO:0003924 GTPase activity(GO:0003924)
0.5 94.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9 52.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.7 47.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
3.4 43.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.1 27.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
6.8 27.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
2.0 26.3 GO:0031386 protein tag(GO:0031386)
4.7 23.6 GO:0050700 CARD domain binding(GO:0050700)
0.8 17.5 GO:0070628 proteasome binding(GO:0070628)
2.7 16.4 GO:0016936 galactoside binding(GO:0016936)
0.2 15.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
3.8 15.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
2.9 14.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.2 14.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 13.5 GO:0045295 gamma-catenin binding(GO:0045295)
4.4 13.2 GO:0070052 collagen V binding(GO:0070052)
3.1 12.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
2.3 11.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 78.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.7 31.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 25.3 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 21.4 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.3 20.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 14.7 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.2 13.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
1.4 12.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 12.8 PID_BARD1_PATHWAY BARD1 signaling events
0.2 12.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 12.1 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.2 11.2 PID_PLK1_PATHWAY PLK1 signaling events
0.3 10.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 10.1 NABA_COLLAGENS Genes encoding collagen proteins
0.2 8.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 8.6 PID_MYC_PATHWAY C-MYC pathway
0.2 7.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 7.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.3 5.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 5.0 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 130.0 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
2.2 56.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
11.0 32.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.8 15.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 12.9 REACTOME_INTERFERON_SIGNALING Genes involved in Interferon Signaling
0.9 11.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 11.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 11.3 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 11.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.8 10.5 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.2 10.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.9 10.2 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4 10.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 10.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.2 9.3 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.8 8.8 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.4 8.2 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.4 8.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 5.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.2 5.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity