Motif ID: Irf3

Z-value: 1.036


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.171.5e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_71537402 11.170 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_+_114896936 8.776 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr3_+_142530329 7.931 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr6_-_39118211 7.276 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr3_+_142560052 6.659 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_142560351 6.651 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr3_+_142560108 6.466 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr11_-_49064202 6.250 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr2_+_122147680 6.236 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr11_-_48871408 6.022 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr17_+_75178797 5.750 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr17_+_75178911 5.258 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr11_-_48871344 4.573 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr16_+_35938470 4.467 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr6_-_54972603 4.422 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr15_+_32920723 4.253 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr4_-_40239779 3.909 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr18_-_32559914 3.784 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr11_+_58199556 3.725 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr3_+_81932601 3.691 ENSMUST00000029649.2
 Ctso
cathepsin O
chr16_+_35938972 3.424 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_173218879 3.311 ENSMUST00000109116.2
ENSMUST00000029018.7
 Zbp1

Z-DNA binding protein 1

chr3_-_151749877 3.220 ENSMUST00000029671.7
 Ifi44
interferon-induced protein 44
chr17_-_34187219 3.061 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_-_48992226 3.038 ENSMUST00000059930.2
ENSMUST00000068063.3
 Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr16_-_35871544 2.795 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr2_-_173276144 2.702 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr4_-_40239700 2.693 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr13_-_23710714 2.610 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr7_-_141266415 2.565 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
 Irf7


interferon regulatory factor 7


chr17_+_34187545 2.494 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_119393060 2.440 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr17_+_34187789 2.402 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_104315455 2.388 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr13_+_74639866 2.214 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr2_-_62646146 2.173 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr13_+_40859768 2.098 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chrX_+_68678541 2.078 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr16_+_23609895 2.041 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr15_+_79892397 1.942 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr2_-_51934644 1.871 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr19_+_36409719 1.776 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr15_+_79892436 1.769 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr19_+_43752996 1.708 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr7_-_78578308 1.510 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr2_-_126933229 1.311 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr14_+_55578123 1.309 ENSMUST00000174484.1
 Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_+_21008921 1.197 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr14_+_14012491 1.191 ENSMUST00000022257.2
 Atxn7
ataxin 7
chrX_+_68678624 1.155 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr14_+_55578360 1.137 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
 Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr4_-_156200818 1.114 ENSMUST00000085425.4
 Isg15
ISG15 ubiquitin-like modifier
chr11_+_72301613 1.082 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr9_+_20868628 1.046 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chrX_+_68678712 1.037 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr2_-_51934943 1.010 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr6_-_34317442 0.984 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr10_+_83543941 0.903 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr5_-_137116177 0.885 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr2_+_167062934 0.802 ENSMUST00000125674.1
 1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr16_-_10785525 0.767 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr1_+_37890477 0.521 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr7_-_45136231 0.502 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr14_-_65833963 0.499 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr15_-_39112642 0.491 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr2_-_145935014 0.437 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr1_-_85109449 0.414 ENSMUST00000161724.1
 A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chrX_-_38576166 0.356 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr10_-_81496313 0.326 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr10_-_81496329 0.241 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr16_-_35939082 0.227 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr7_-_102565425 0.223 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr14_-_55591077 0.183 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr1_-_75317536 0.179 ENSMUST00000066668.7
 Dnpep
aspartyl aminopeptidase
chr8_-_70766654 0.174 ENSMUST00000034299.5
 Ifi30
interferon gamma inducible protein 30
chr1_-_75316998 0.156 ENSMUST00000113605.3
 Dnpep
aspartyl aminopeptidase
chrX_-_38576189 0.049 ENSMUST00000115118.1
 Cul4b
cullin 4B
chr7_-_100514800 0.003 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.4 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
3.6 14.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
2.2 8.8 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.8 8.8 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
1.6 27.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
1.4 8.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.2 4.9 GO:0046967 cytosol to ER transport(GO:0046967)
0.9 4.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.7 2.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 2.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.6 3.7 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.6 5.9 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.5 2.7 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.5 1.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 2.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.4 11.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 9.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 2.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.3 1.0 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.2 2.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 1.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 1.1 GO:0035456 response to interferon-beta(GO:0035456)
0.2 1.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 0.5 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 1.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 2.8 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 12.1 GO:0051607 defense response to virus(GO:0051607)
0.1 1.7 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 3.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 4.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.6 GO:0031648 protein destabilization(GO:0031648)
0.0 3.0 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
2.4 31.4 GO:0020003 symbiont-containing vacuole(GO:0020003)
1.1 4.3 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.9 8.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.8 3.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 10.6 GO:0044754 autolysosome(GO:0044754)
0.7 4.9 GO:0042825 TAP complex(GO:0042825)
0.6 2.4 GO:0008537 proteasome activator complex(GO:0008537)
0.3 1.3 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 1.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 11.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 6.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 2.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 3.8 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 9.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.0 GO:0050436 microfibril binding(GO:0050436)
1.2 4.9 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
1.1 5.7 GO:0050700 CARD domain binding(GO:0050700)
1.1 3.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.9 11.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.9 3.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.9 18.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 2.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.6 4.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 8.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 1.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 2.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 2.6 GO:0039706 co-receptor binding(GO:0039706)
0.3 2.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 3.1 GO:0070628 proteasome binding(GO:0070628)
0.1 39.5 GO:0003924 GTPase activity(GO:0003924)
0.1 8.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.0 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 4.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0005507 copper ion binding(GO:0005507)
0.0 2.0 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 19.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 4.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 6.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 11.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.5 PID_SHP2_PATHWAY SHP2 signaling
0.0 4.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 11.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 7.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 8.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 4.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 1.9 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.2 3.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 4.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation