Motif ID: Irf3

Z-value: 1.036


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.171.5e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_71537402 11.170 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_+_114896936 8.776 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr3_+_142530329 7.931 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr6_-_39118211 7.276 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr3_+_142560052 6.659 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_142560351 6.651 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr3_+_142560108 6.466 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr11_-_49064202 6.250 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr2_+_122147680 6.236 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr11_-_48871408 6.022 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr17_+_75178797 5.750 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr17_+_75178911 5.258 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr11_-_48871344 4.573 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr16_+_35938470 4.467 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr6_-_54972603 4.422 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr15_+_32920723 4.253 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr4_-_40239779 3.909 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr18_-_32559914 3.784 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr11_+_58199556 3.725 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr3_+_81932601 3.691 ENSMUST00000029649.2
 Ctso
cathepsin O

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 27.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
3.9 15.4 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
3.6 14.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 12.1 GO:0051607 defense response to virus(GO:0051607)
0.4 11.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 9.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
2.2 8.8 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.8 8.8 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
1.4 8.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.6 5.9 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.2 4.9 GO:0046967 cytosol to ER transport(GO:0046967)
0.9 4.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 4.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 3.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.6 3.7 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.0 3.0 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)
0.7 2.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 2.8 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.5 2.7 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 2.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 31.4 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 11.2 GO:0031225 anchored component of membrane(GO:0031225)
3.7 11.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.7 10.6 GO:0044754 autolysosome(GO:0044754)
0.0 9.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.9 8.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 6.6 GO:0032587 ruffle membrane(GO:0032587)
0.7 4.9 GO:0042825 TAP complex(GO:0042825)
1.1 4.3 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.0 3.8 GO:0030863 cortical cytoskeleton(GO:0030863)
0.8 3.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 2.7 GO:0031901 early endosome membrane(GO:0031901)
0.6 2.4 GO:0008537 proteasome activator complex(GO:0008537)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0031519 PcG protein complex(GO:0031519)
0.3 1.3 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 1.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.5 GO:0003924 GTPase activity(GO:0003924)
0.9 18.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.9 11.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
2.8 11.0 GO:0050436 microfibril binding(GO:0050436)
0.4 8.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 8.8 GO:0003725 double-stranded RNA binding(GO:0003725)
1.1 5.7 GO:0050700 CARD domain binding(GO:0050700)
1.2 4.9 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.6 4.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 4.3 GO:0030165 PDZ domain binding(GO:0030165)
0.9 3.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
1.1 3.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.2 3.1 GO:0070628 proteasome binding(GO:0070628)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.3 2.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 2.6 GO:0039706 co-receptor binding(GO:0039706)
0.0 2.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 2.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 2.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 11.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 4.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 4.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.5 PID_SHP2_PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 8.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.4 7.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.1 6.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 4.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 4.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 3.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 1.9 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 1.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling