Motif ID: Irf4
Z-value: 0.568
Transcription factors associated with Irf4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irf4 | ENSMUSG00000021356.3 | Irf4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.2 | GO:0006710 | androgen catabolic process(GO:0006710) |
| 1.1 | 3.4 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.1 | 3.3 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.9 | 2.8 | GO:1900041 | intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896) |
| 0.8 | 4.1 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 0.8 | 2.5 | GO:1903054 | negative regulation of extracellular matrix organization(GO:1903054) |
| 0.6 | 1.8 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.5 | 2.7 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.4 | 1.6 | GO:0002589 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) |
| 0.4 | 1.9 | GO:0032621 | interleukin-18 production(GO:0032621) |
| 0.4 | 1.5 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 0.3 | 1.8 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.3 | 0.8 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673) |
| 0.2 | 1.3 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.2 | 1.1 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.2 | 2.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.2 | 3.1 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 1.2 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.2 | 2.2 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.2 | 2.2 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.2 | 2.8 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 1.6 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 0.4 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 2.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.3 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.1 | 1.6 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 1.2 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.1 | 0.3 | GO:1902915 | negative regulation of protein import into nucleus, translocation(GO:0033159) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.1 | 1.5 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.1 | 0.7 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.1 | 0.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 0.7 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 0.1 | 0.5 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 0.1 | 1.3 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.1 | 2.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.4 | GO:0000429 | carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
| 0.1 | 0.7 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.0 | 4.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.2 | GO:0045629 | positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 4.6 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.0 | 0.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 1.3 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.0 | 0.2 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.0 | 0.4 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.6 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.3 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.8 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.3 | GO:0060253 | negative regulation of glial cell proliferation(GO:0060253) |
| 0.0 | 0.1 | GO:0035799 | ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) |
| 0.0 | 0.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.3 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
| 0.0 | 0.9 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.3 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.1 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.0 | 2.3 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.2 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.2 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 0.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.5 | 2.7 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.3 | 1.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.2 | 2.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 0.3 | GO:0034679 | integrin alpha9-beta1 complex(GO:0034679) |
| 0.1 | 1.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 0.6 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 1.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 0.5 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 0.7 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 0.4 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 0.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 5.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 3.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 4.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 3.4 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.1 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.0 | 0.7 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.5 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 1.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.1 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.9 | 2.8 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.9 | 2.7 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.9 | 3.4 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.8 | 3.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.7 | 5.2 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.7 | 2.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.2 | 1.0 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.2 | 2.8 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.2 | 3.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 0.8 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.2 | 1.1 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 1.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 0.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 1.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 2.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 1.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 0.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 2.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.1 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.1 | 0.4 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.1 | 2.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.2 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.1 | 0.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 1.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 2.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.3 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.0 | 1.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.1 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.0 | 0.1 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.4 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 3.1 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 2.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 4.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 2.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 2.4 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 4.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 2.7 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 3.9 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 3.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.8 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.3 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 2.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.8 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 1.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.0 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.6 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.3 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.9 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.2 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.4 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.1 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
