Motif ID: Irf4
Z-value: 0.568
Transcription factors associated with Irf4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irf4 | ENSMUSG00000021356.3 | Irf4 |
Top targets:
Showing 1 to 20 of 130 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 60 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.2 | GO:0006710 | androgen catabolic process(GO:0006710) |
| 0.0 | 4.6 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 4.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.8 | 4.1 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 1.1 | 3.4 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.1 | 3.3 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.2 | 3.1 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.9 | 2.8 | GO:1900041 | intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896) |
| 0.2 | 2.8 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.5 | 2.7 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.1 | 2.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.8 | 2.5 | GO:1903054 | negative regulation of extracellular matrix organization(GO:1903054) |
| 0.1 | 2.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 2.3 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.2 | 2.2 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.2 | 2.2 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.2 | 2.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.4 | 1.9 | GO:0032621 | interleukin-18 production(GO:0032621) |
| 0.6 | 1.8 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.3 | 1.8 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 30 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 3.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 3.4 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.9 | 2.8 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.5 | 2.7 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 2.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 2.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 1.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 1.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 0.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.2 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 1.0 | 4.1 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.2 | 3.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.9 | 3.4 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.8 | 3.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.9 | 2.8 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.2 | 2.8 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.9 | 2.7 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 2.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 2.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 2.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.7 | 2.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.1 | 2.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 1.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 1.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 1.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in C2:CP category:
Showing 1 to 15 of 15 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 3.1 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 2.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 1.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 22 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 3.9 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 3.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.8 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 2.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 2.7 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.4 | 2.4 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 2.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.7 | 2.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.8 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.6 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.3 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.1 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.0 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.9 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.3 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
