Motif ID: Irx4

Z-value: 0.223


Transcription factors associated with Irx4:

Gene SymbolEntrez IDGene Name
Irx4 ENSMUSG00000021604.9 Irx4



Activity profile for motif Irx4.

activity profile for motif Irx4


Sorted Z-values histogram for motif Irx4

Sorted Z-values for motif Irx4



Network of associatons between targets according to the STRING database.


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_11970540 2.291 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr1_+_45311538 1.536 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_-_3494587 1.125 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr8_+_84872105 0.807 ENSMUST00000136026.1
ENSMUST00000170296.1
 Syce2

synaptonemal complex central element protein 2

chr9_-_58202281 0.697 ENSMUST00000163897.1
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_-_79908428 0.375 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr6_-_83317589 0.356 ENSMUST00000005810.6
 Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr2_-_79908389 0.299 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr15_-_35938009 0.293 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr15_-_35938186 0.280 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr3_+_27317028 0.194 ENSMUST00000046383.5
ENSMUST00000174840.1
 Tnfsf10

tumor necrosis factor (ligand) superfamily, member 10

chr3_-_57651667 0.176 ENSMUST00000160959.1
 Commd2
COMM domain containing 2
chr18_-_37178493 0.119 ENSMUST00000181887.1
ENSMUST00000180516.1
 Gm10544

predicted gene 10544

chr4_+_48663502 0.026 ENSMUST00000030033.4
 Murc
muscle-related coiled-coil protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 2.3 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.8 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.7 GO:0045773 positive regulation of axon extension(GO:0045773)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0000801 central element(GO:0000801)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis