Motif ID: Irx5

Z-value: 0.566


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.151.9e-01Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 7.556 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 5.044 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr2_-_79908389 3.765 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr12_-_67222549 3.007 ENSMUST00000037181.8
 Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr12_+_38783503 2.540 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr6_+_50110837 2.521 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr7_-_114927726 2.362 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr19_+_26623419 2.343 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_85035487 2.239 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr3_+_124321031 2.167 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr14_-_19977040 1.828 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 1.778 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr1_+_165301863 1.717 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr3_-_126998408 1.582 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr14_-_19977249 1.519 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr12_+_55598917 1.399 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr9_-_78378725 1.335 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr5_-_88675190 1.282 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr14_+_48120841 1.264 ENSMUST00000073150.4
 Peli2
pellino 2
chr4_-_49521036 1.261 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr11_-_68927049 1.256 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr4_+_43632185 1.254 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr2_-_101621033 1.243 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr4_-_43653542 1.231 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr12_-_108893197 1.229 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr7_+_45785331 1.199 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr4_-_43653560 1.176 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr17_+_21657582 1.139 ENSMUST00000039726.7
 3110052M02Rik
RIKEN cDNA 3110052M02 gene
chrX_+_135742686 1.113 ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
ENSMUST00000096321.2
 Gprasp1


Armcx5
G protein-coupled receptor associated sorting protein 1


armadillo repeat containing, X-linked 5
chr4_+_43631935 1.097 ENSMUST00000030191.8
 Npr2
natriuretic peptide receptor 2
chr12_-_99393010 1.012 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr13_+_24943144 0.989 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr1_-_78968079 0.988 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr10_+_3872667 0.973 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr3_+_95124476 0.955 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr2_+_152427639 0.815 ENSMUST00000128737.1
 6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr10_-_13868779 0.772 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr1_-_169969143 0.747 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr7_-_98112618 0.719 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr10_-_99759658 0.693 ENSMUST00000056085.4
 Csl
citrate synthase like
chr11_-_28339867 0.668 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr4_+_6365650 0.648 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr4_-_59783800 0.597 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr12_+_69893105 0.582 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr10_-_88146867 0.575 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr11_+_69098937 0.549 ENSMUST00000021271.7
 Per1
period circadian clock 1
chr14_-_14120904 0.532 ENSMUST00000022256.3
 Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr16_-_56024628 0.515 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr16_-_55838827 0.511 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr16_+_33185045 0.505 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr11_-_69395333 0.481 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr9_-_7835255 0.481 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr2_-_73625731 0.478 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr8_+_85171322 0.436 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr11_-_69579320 0.359 ENSMUST00000048139.5
 Wrap53
WD repeat containing, antisense to Trp53
chr4_+_148039097 0.337 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr12_-_85288419 0.336 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr2_+_104027823 0.273 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr10_+_79960145 0.204 ENSMUST00000045247.7
 Wdr18
WD repeat domain 18
chr10_+_88146992 0.201 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr11_-_49712674 0.188 ENSMUST00000020624.6
ENSMUST00000145353.1
 Cnot6

CCR4-NOT transcription complex, subunit 6

chr14_+_48446340 0.121 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr10_+_97565436 0.097 ENSMUST00000038160.4
 Lum
lumican
chr5_+_23787691 0.094 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
 Rint1



RAD50 interactor 1



chr3_+_63963631 0.079 ENSMUST00000181653.1
 Gm26850
predicted gene, 26850
chr8_+_4240105 0.072 ENSMUST00000110994.1
ENSMUST00000110995.1
 Map2k7

mitogen-activated protein kinase kinase 7

chr17_+_87025550 0.039 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein

chr5_+_48242549 0.006 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.7 2.2 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.5 8.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.4 1.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 1.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.3 2.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 2.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 2.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 1.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 0.5 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.2 1.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 1.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.6 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 1.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.7 GO:0050957 equilibrioception(GO:0050957)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 1.0 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.2 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 1.1 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.1 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 3.7 GO:0009566 fertilization(GO:0009566)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.7 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0001520 outer dense fiber(GO:0001520)
0.1 2.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 0.6 GO:0070876 SOSS complex(GO:0070876)
0.1 5.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0012505 endomembrane system(GO:0012505)
0.1 1.6 GO:0031430 M band(GO:0031430)
0.1 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.8 GO:0043025 neuronal cell body(GO:0043025)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.8 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.5 2.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 1.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.4 2.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3 5.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 0.7 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 0.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.0 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.6 GO:0045545 syndecan binding(GO:0045545)
0.1 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 1.4 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 5.1 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.3 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.2 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)