Motif ID: Irx6_Irx2_Irx3

Z-value: 0.716

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx6mm10_v2_chr8_+_92674826_926748260.113.2e-01Click!
Irx2mm10_v2_chr13_+_72628802_726288250.056.8e-01Click!
Irx3mm10_v2_chr8_-_91801948_918020670.019.6e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 9.819 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr10_-_125328957 8.296 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr16_+_17146937 6.799 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr7_-_112159034 6.731 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr9_-_124493793 6.130 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr8_+_36489191 5.298 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr13_+_76579670 5.236 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr7_-_103827922 4.595 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr6_-_48708206 4.066 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr2_-_98667264 3.813 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr13_+_49504774 3.812 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_169587745 3.752 ENSMUST00000109160.2
 Gm11011
predicted gene 11011
chr1_+_159737510 3.628 ENSMUST00000111669.3
 Tnr
tenascin R
chr14_-_30353468 3.465 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr13_+_16014457 2.961 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr8_+_129118043 2.905 ENSMUST00000108744.1
 1700008F21Rik
RIKEN cDNA 1700008F21 gene
chr2_-_67433181 2.710 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr2_-_119271202 2.665 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chr17_-_27133902 2.659 ENSMUST00000119227.1
ENSMUST00000025045.8
 Uqcc2

ubiquinol-cytochrome c reductase complex assembly factor 2

chr3_-_87263518 2.412 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 9.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.1 8.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
1.4 7.1 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.5 5.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 3.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 3.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.9 3.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.9 3.5 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.6 3.0 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 2.9 GO:0034605 cellular response to heat(GO:0034605)
0.2 2.7 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 2.7 GO:0007052 mitotic spindle organization(GO:0007052)
0.4 2.1 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.3 2.1 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 1.9 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 1.9 GO:0007601 visual perception(GO:0007601)
0.6 1.7 GO:0070543 response to linoleic acid(GO:0070543)
0.3 1.6 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.4 1.5 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.1 4.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 4.0 GO:0005581 collagen trimer(GO:0005581)
0.2 3.8 GO:0005614 interstitial matrix(GO:0005614)
1.2 3.6 GO:0072534 perineuronal net(GO:0072534)
0.3 3.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.0 3.0 GO:0043512 inhibin A complex(GO:0043512)
0.1 3.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 2.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 2.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.5 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 1.5 GO:0061574 ASAP complex(GO:0061574)
0.1 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 1.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.1 8.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 6.2 GO:0005525 GTP binding(GO:0005525)
0.9 5.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
1.1 4.6 GO:0031720 haptoglobin binding(GO:0031720)
1.3 3.8 GO:0070052 collagen V binding(GO:0070052)
0.2 3.6 GO:0046625 sphingolipid binding(GO:0046625)
0.4 3.5 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.5 3.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 2.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 1.9 GO:0019841 retinol binding(GO:0019841)
0.6 1.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.3 1.6 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.1 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 6.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.0 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.5 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.9 8.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.7 3.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 2.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.7 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.1 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 1.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.9 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.8 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis