Motif ID: Irx6_Irx2_Irx3
Z-value: 0.716
Transcription factors associated with Irx6_Irx2_Irx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irx2 | ENSMUSG00000001504.9 | Irx2 |
| Irx3 | ENSMUSG00000031734.11 | Irx3 |
| Irx6 | ENSMUSG00000031738.8 | Irx6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irx6 | mm10_v2_chr8_+_92674826_92674826 | 0.11 | 3.2e-01 | Click! |
| Irx2 | mm10_v2_chr13_+_72628802_72628825 | 0.05 | 6.8e-01 | Click! |
| Irx3 | mm10_v2_chr8_-_91801948_91802067 | 0.01 | 9.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.3 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 2.0 | 9.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.4 | 7.1 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 0.9 | 3.5 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.9 | 3.5 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.6 | 3.0 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.6 | 1.7 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.5 | 5.3 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.5 | 0.5 | GO:0006517 | protein deglycosylation(GO:0006517) |
| 0.4 | 2.1 | GO:0072008 | glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) |
| 0.4 | 1.5 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.3 | 1.6 | GO:0002677 | negative regulation of chronic inflammatory response(GO:0002677) |
| 0.3 | 1.0 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.3 | 2.1 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 0.3 | 0.8 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.3 | 1.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.2 | 2.7 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.2 | 0.7 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.2 | 0.7 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.2 | 1.1 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.2 | 1.1 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 0.2 | 0.6 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
| 0.2 | 0.6 | GO:0032817 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) |
| 0.2 | 0.6 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.2 | 0.5 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.2 | 0.7 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.2 | 3.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 0.5 | GO:0043379 | memory T cell differentiation(GO:0043379) |
| 0.1 | 0.4 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.4 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.1 | 0.4 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.1 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 0.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 0.6 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 0.9 | GO:0051792 | medium-chain fatty acid biosynthetic process(GO:0051792) |
| 0.1 | 1.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.1 | 0.4 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
| 0.1 | 0.4 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.9 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 1.0 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.5 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.1 | 1.9 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
| 0.1 | 0.4 | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) |
| 0.1 | 0.4 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.3 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.1 | 0.8 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 0.2 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.1 | 1.3 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 0.7 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.1 | 0.2 | GO:0034035 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.1 | 0.6 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.1 | 0.2 | GO:0006507 | GPI anchor release(GO:0006507) |
| 0.1 | 0.3 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 0.1 | 0.4 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.1 | 0.2 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 0.7 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.1 | 0.3 | GO:0042758 | long-chain fatty acid catabolic process(GO:0042758) |
| 0.1 | 2.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 0.7 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.1 | 0.2 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.0 | 0.5 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 0.0 | 0.4 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.0 | 0.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 0.8 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 0.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.2 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.0 | 0.5 | GO:0034312 | diol biosynthetic process(GO:0034312) |
| 0.0 | 0.1 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.0 | 0.2 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.0 | 0.4 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 0.6 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 0.3 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.4 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 1.1 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.5 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 0.6 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.1 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.0 | 0.5 | GO:0017144 | drug metabolic process(GO:0017144) |
| 0.0 | 3.8 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.4 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.6 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.1 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 0.3 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.0 | 2.7 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.0 | 0.2 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.3 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.3 | GO:0015809 | arginine transport(GO:0015809) |
| 0.0 | 1.0 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.4 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.0 | 0.3 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.0 | 0.2 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.1 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.0 | 1.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.2 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.0 | 1.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.5 | GO:0033006 | regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304) |
| 0.0 | 0.7 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 0.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.1 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.0 | 0.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.1 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.2 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.1 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 0.2 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.0 | 0.4 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.1 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.0 | 0.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0015816 | glycine transport(GO:0015816) |
| 0.0 | 0.1 | GO:0070842 | aggresome assembly(GO:0070842) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.1 | 4.6 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.0 | 3.0 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.8 | 9.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.5 | 2.1 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.3 | 3.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.3 | 1.5 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.2 | 3.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 1.1 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.2 | 0.5 | GO:0034657 | GID complex(GO:0034657) |
| 0.2 | 1.5 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.2 | 1.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.2 | 2.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.4 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.1 | 0.7 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 0.4 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 0.8 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.5 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.3 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
| 0.1 | 0.3 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.1 | 1.0 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 0.4 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 0.3 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.1 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 3.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 0.4 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.0 | 0.3 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.5 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.4 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.5 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 0.4 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 0.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.7 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 3.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.6 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.3 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.0 | 1.7 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 1.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.3 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.1 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.3 | 3.8 | GO:0070052 | collagen V binding(GO:0070052) |
| 1.1 | 4.6 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.9 | 5.3 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.7 | 10.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.6 | 1.7 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 3.0 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.4 | 3.5 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.3 | 1.0 | GO:0004686 | elongation factor-2 kinase activity(GO:0004686) |
| 0.3 | 1.6 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.3 | 1.9 | GO:0019841 | retinol binding(GO:0019841) |
| 0.3 | 1.1 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.3 | 0.8 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.3 | 1.1 | GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) |
| 0.2 | 1.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 1.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 3.6 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 0.6 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
| 0.2 | 1.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.2 | 0.8 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.1 | 1.0 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 0.4 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.1 | 0.8 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.1 | 0.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.4 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.1 | 0.5 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.1 | 1.1 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.3 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.1 | 1.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 0.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 0.7 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 0.3 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.1 | 0.9 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 0.3 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 0.3 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.3 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.1 | 0.4 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.1 | 0.3 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.1 | 1.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.9 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 0.5 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.4 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.0 | 0.9 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 0.3 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.0 | 0.2 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 0.5 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 0.3 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.7 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.5 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 2.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.2 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.1 | GO:0008297 | single-stranded DNA exodeoxyribonuclease activity(GO:0008297) |
| 0.0 | 0.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 0.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 1.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.2 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.0 | 1.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 6.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.2 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 0.1 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 0.1 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.0 | 0.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.6 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 6.7 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 6.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.1 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.9 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 1.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.4 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.7 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.1 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.6 | NABA_CORE_MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 0.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 0.2 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.3 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.7 | 3.0 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.3 | 2.0 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 10.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.5 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 3.2 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 0.9 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.5 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 1.1 | REACTOME_POL_SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 1.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 0.7 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 0.3 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.1 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.4 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 0.8 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 1.0 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.7 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.6 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.7 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.5 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.4 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.0 | 0.7 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.6 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.1 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.1 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.1 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.6 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
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