Motif ID: Isl1

Z-value: 0.474


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.181.1e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56978534 6.000 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_112187898 4.876 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr15_-_93519499 4.692 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr9_-_112217261 3.372 ENSMUST00000159451.1
ENSMUST00000162796.1
ENSMUST00000161097.1
 Arpp21


cyclic AMP-regulated phosphoprotein, 21


chr14_+_124005355 3.244 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr4_-_14621805 2.769 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr9_+_53771499 2.593 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chrX_-_43274786 2.518 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr6_-_144209558 2.496 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 2.457 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 2.426 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr2_+_67748212 2.406 ENSMUST00000180887.1
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr18_-_35215008 2.377 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chrX_+_153237466 2.277 ENSMUST00000143880.1
 Klf8
Kruppel-like factor 8
chrX_+_99975570 2.182 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr8_+_84723003 2.098 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr4_+_74013442 2.088 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr9_-_40346290 2.049 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr9_-_112217344 1.884 ENSMUST00000161412.1
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr12_-_86884808 1.766 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 GO:0034605 cellular response to heat(GO:0034605)
0.9 7.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.5 7.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 5.7 GO:0019532 oxalate transport(GO:0019532)
1.6 4.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 2.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 2.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.7 2.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 2.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.8 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.2 1.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.3 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.4 1.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 1.2 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.4 1.1 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 1.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.8 GO:0016235 aggresome(GO:0016235)
0.0 3.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.2 GO:0005581 collagen trimer(GO:0005581)
0.1 2.1 GO:0031430 M band(GO:0031430)
0.0 1.8 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.3 1.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.2 0.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0097513 myosin II filament(GO:0097513)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 8.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.5 5.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 4.7 GO:0008134 transcription factor binding(GO:0008134)
0.0 3.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.6 GO:0030507 spectrin binding(GO:0030507)
0.6 2.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 1.2 GO:0019808 polyamine binding(GO:0019808)
0.3 1.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.4 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 1.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 0.8 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins