Motif ID: Isl2

Z-value: 0.858


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 179 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53771499 8.011 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_+_102589687 5.141 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr11_+_103649498 4.988 ENSMUST00000057870.2
 Rprml
reprimo-like
chr15_+_16778101 4.593 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr12_+_109546409 4.468 ENSMUST00000143847.1
 Meg3
maternally expressed 3
chr17_+_17402672 4.243 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr14_+_4198185 4.113 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr16_-_16829276 4.028 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chrX_+_164373363 3.986 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr8_+_25911670 3.817 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr4_-_14621805 3.733 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr6_-_136941887 3.381 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr10_-_63927434 3.190 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr14_+_5517172 3.154 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 3.154 ENSMUST00000179659.1
 Gm3317
predicted gene 3317
chr13_-_58354862 2.996 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr3_-_113574242 2.868 ENSMUST00000142505.2
 Amy1
amylase 1, salivary
chr15_-_37459327 2.802 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr14_+_3667518 2.801 ENSMUST00000112801.3
 Gm3020
predicted gene 3020
chr14_-_7473073 2.689 ENSMUST00000167833.2
 Gm3752
predicted gene 3752

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.4 GO:0019532 oxalate transport(GO:0019532)
0.4 5.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 4.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 4.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 4.2 GO:0097352 autophagosome maturation(GO:0097352)
0.0 3.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 3.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 3.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 3.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 2.9 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.2 2.6 GO:0070842 aggresome assembly(GO:0070842)
0.8 2.4 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.6 2.3 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.5 2.3 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.2 2.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 2.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 2.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.2 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 2.2 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.7 2.0 GO:0009106 lipoate metabolic process(GO:0009106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 5.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.7 GO:0035371 microtubule plus-end(GO:0035371)
0.6 2.3 GO:0071438 invadopodium membrane(GO:0071438)
0.1 2.3 GO:0032433 filopodium tip(GO:0032433)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 2.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 1.8 GO:0061617 MICOS complex(GO:0061617)
0.1 1.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 1.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.2 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 5.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.3 3.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.5 3.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.0 2.9 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 2.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)
0.8 2.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.4 2.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 2.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 2.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.3 1.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.4 GO:0042923 neuropeptide binding(GO:0042923)
0.3 1.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 4.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 2.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 1.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 7.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 4.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 2.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 1.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters