Motif ID: Isl2

Z-value: 0.858


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_53771499 8.011 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr4_+_102589687 5.141 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr11_+_103649498 4.988 ENSMUST00000057870.2
Rprml
reprimo-like
chr15_+_16778101 4.593 ENSMUST00000026432.6
Cdh9
cadherin 9
chr12_+_109546409 4.468 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr17_+_17402672 4.243 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr14_+_4198185 4.113 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr16_-_16829276 4.028 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chrX_+_164373363 3.986 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr8_+_25911670 3.817 ENSMUST00000120653.1
ENSMUST00000126226.1
Kcnu1

potassium channel, subfamily U, member 1

chr4_-_14621805 3.733 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr6_-_136941887 3.381 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr10_-_63927434 3.190 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr14_+_5517172 3.154 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 3.154 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr13_-_58354862 2.996 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr3_-_113574242 2.868 ENSMUST00000142505.2
Amy1
amylase 1, salivary
chr15_-_37459327 2.802 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr14_+_3667518 2.801 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chr14_-_7473073 2.689 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr18_+_23753708 2.686 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr8_-_54724317 2.657 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr17_+_70561739 2.639 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_118244861 2.634 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr14_+_3348089 2.617 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chr14_-_6874257 2.546 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr1_+_110099295 2.538 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr5_+_66968559 2.529 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr4_-_14621669 2.470 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr14_-_6411578 2.462 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr14_+_4741737 2.460 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr14_+_4871156 2.430 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr14_+_4126066 2.422 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr14_+_3428103 2.419 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr14_+_4430992 2.417 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr1_+_72284367 2.393 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr14_+_3825596 2.372 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chrX_-_134111852 2.292 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr9_-_102354685 2.260 ENSMUST00000035129.7
ENSMUST00000085169.5
Ephb1

Eph receptor B1

chr14_-_5863663 2.247 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr17_+_12119274 2.238 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr8_+_95703037 2.218 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4

N-myc downstream regulated gene 4

chr5_-_24902315 2.164 ENSMUST00000131486.1
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr14_-_19569553 2.161 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr5_+_66968961 2.155 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr4_-_14621494 2.150 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr14_-_6266620 2.128 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr14_+_4665094 2.048 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chr7_+_100159241 1.991 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr14_-_6741430 1.982 ENSMUST00000100904.4
Gm3636
predicted gene 3636
chr18_-_43477764 1.900 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_-_109764840 1.835 ENSMUST00000163071.1
Nav3
neuron navigator 3
chr3_-_67463828 1.779 ENSMUST00000058981.2
Lxn
latexin
chr6_-_89595647 1.758 ENSMUST00000032172.8
ENSMUST00000113550.3
Chchd6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr1_-_56969864 1.715 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr13_+_67833235 1.690 ENSMUST00000060609.7
Gm10037
predicted gene 10037
chr4_-_88722454 1.680 ENSMUST00000094993.2
Klhl9
kelch-like 9
chr10_+_116143881 1.678 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr11_+_5520652 1.599 ENSMUST00000063084.9
Xbp1
X-box binding protein 1
chrX_+_37126777 1.586 ENSMUST00000016553.4
Nkap
NFKB activating protein
chr19_+_25406661 1.532 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr1_-_9944103 1.527 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr19_+_5490475 1.503 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr10_+_102158858 1.435 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr9_+_58629102 1.422 ENSMUST00000176250.1
Nptn
neuroplastin
chr3_-_62605140 1.417 ENSMUST00000058535.5
Gpr149
G protein-coupled receptor 149
chr8_+_93810832 1.310 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr12_+_10390756 1.292 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr10_+_88379217 1.292 ENSMUST00000130301.1
ENSMUST00000020251.8
Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr10_+_94576254 1.289 ENSMUST00000117929.1
Tmcc3
transmembrane and coiled coil domains 3
chr15_-_10485385 1.289 ENSMUST00000168690.1
Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chrX_-_75578188 1.281 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr3_-_33082004 1.256 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr8_-_9976294 1.237 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr4_+_47386216 1.235 ENSMUST00000107725.2
Tgfbr1
transforming growth factor, beta receptor I
chr17_+_85028347 1.232 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr11_-_98018308 1.205 ENSMUST00000107561.2
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr14_-_31323884 1.194 ENSMUST00000048603.7
Dnah1
dynein, axonemal, heavy chain 1
chr2_-_45112890 1.193 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr17_+_20570362 1.172 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chr11_-_101278927 1.118 ENSMUST00000168089.1
ENSMUST00000017332.3
Coa3

cytochrome C oxidase assembly factor 3

chr3_-_9004422 1.073 ENSMUST00000063496.7
Tpd52
tumor protein D52
chr14_-_104522615 1.071 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr12_-_10900296 1.068 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr10_-_80918212 1.039 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr13_+_48513570 1.035 ENSMUST00000065465.1
A830005F24Rik
RIKEN cDNA A830005F24 gene
chr9_-_107872403 1.011 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr8_+_64947177 1.000 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr6_+_125049903 0.998 ENSMUST00000112413.1
Acrbp
proacrosin binding protein
chr17_-_53867041 0.952 ENSMUST00000061311.7
Mrps36-ps1
mitichondrial ribosomal protein S36, pseudogene 1
chr15_-_10485890 0.947 ENSMUST00000169050.1
ENSMUST00000022855.5
Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr17_+_78916473 0.944 ENSMUST00000063817.4
ENSMUST00000180077.1
1110001A16Rik

RIKEN cDNA 1110001A16 gene

chr8_+_88118747 0.937 ENSMUST00000095214.3
Cnep1r1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chrX_-_103981242 0.935 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chrM_+_10167 0.927 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr4_+_134102581 0.916 ENSMUST00000074690.4
ENSMUST00000070246.2
ENSMUST00000156750.1
Ubxn11


UBX domain protein 11


chr9_+_108290433 0.907 ENSMUST00000035227.6
Nicn1
nicolin 1
chr15_+_84232030 0.898 ENSMUST00000023072.6
Parvb
parvin, beta
chrX_+_136245065 0.897 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chr16_-_76403673 0.894 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr8_+_107031218 0.882 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr11_+_69838514 0.879 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chr3_+_41024369 0.873 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chrM_+_9452 0.849 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_-_85127977 0.838 ENSMUST00000050813.2
Mterfd3
MTERF domain containing 3
chrX_+_96455359 0.826 ENSMUST00000033553.7
Heph
hephaestin
chr4_+_3940747 0.826 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr3_-_41742471 0.796 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr18_-_36766198 0.794 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr3_+_103171655 0.791 ENSMUST00000005830.8
Bcas2
breast carcinoma amplified sequence 2
chr11_-_80779989 0.790 ENSMUST00000041065.7
ENSMUST00000070997.5
Myo1d

myosin ID

chr8_-_125492710 0.770 ENSMUST00000108775.1
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr2_+_125136692 0.770 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr7_-_6730412 0.764 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr5_-_104828957 0.759 ENSMUST00000089906.6
Zfp951
zinc finger protein 951
chr9_-_15301555 0.758 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr12_+_87443896 0.743 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr3_-_62506970 0.731 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr6_-_42710036 0.725 ENSMUST00000045054.4
Fam115a
family with sequence similarity 115, member A
chr15_-_100424092 0.707 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_-_185329331 0.673 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr17_-_26099257 0.663 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr6_+_8209216 0.647 ENSMUST00000040017.7
Mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr17_-_48432723 0.636 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chrM_+_14138 0.635 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr19_-_44552831 0.611 ENSMUST00000166808.1
Gm20538
predicted gene 20538
chr2_+_115581667 0.587 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr3_-_51408925 0.580 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chrX_-_60893430 0.577 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr10_+_69208546 0.533 ENSMUST00000164034.1
Rhobtb1
Rho-related BTB domain containing 1
chr14_+_58893465 0.529 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr15_-_100424208 0.519 ENSMUST00000154331.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr5_+_146948640 0.493 ENSMUST00000146511.1
ENSMUST00000132102.1
Gtf3a

general transcription factor III A

chr5_-_87490869 0.490 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr15_+_99295087 0.482 ENSMUST00000128352.1
ENSMUST00000145482.1
Prpf40b

PRP40 pre-mRNA processing factor 40 homolog B (yeast)

chr9_+_56418624 0.435 ENSMUST00000034879.3
Hmg20a
high mobility group 20A
chr2_+_163658370 0.433 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig





protein kinase inhibitor, gamma





chr7_+_19119853 0.414 ENSMUST00000053109.3
Fbxo46
F-box protein 46
chr2_+_69897220 0.375 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr6_+_51544513 0.371 ENSMUST00000179365.1
ENSMUST00000114439.1
Snx10

sorting nexin 10

chr4_+_32623985 0.366 ENSMUST00000108178.1
Casp8ap2
caspase 8 associated protein 2
chr3_-_79841729 0.353 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr1_+_45981548 0.344 ENSMUST00000085632.2
Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr7_+_28881656 0.337 ENSMUST00000066880.4
Capn12
calpain 12
chr3_+_89459118 0.332 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chrM_+_3906 0.327 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr9_+_119341294 0.302 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr5_-_3647806 0.300 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr6_+_134640940 0.296 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr11_-_17953861 0.288 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr12_-_87444017 0.278 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr9_-_7835255 0.253 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2
chr3_-_20242173 0.252 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chrX_-_20931520 0.215 ENSMUST00000001156.7
Cfp
complement factor properdin
chr3_+_83055516 0.211 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chrY_-_1245753 0.202 ENSMUST00000154004.1
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr15_-_35938009 0.198 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr15_-_35938186 0.192 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr11_-_71004387 0.186 ENSMUST00000124464.1
ENSMUST00000108527.1
Dhx33

DEAH (Asp-Glu-Ala-His) box polypeptide 33

chr7_+_126976338 0.183 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr8_+_114133557 0.177 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr17_+_74489492 0.165 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr9_+_108560422 0.147 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr1_+_44147847 0.137 ENSMUST00000027214.3
Ercc5
excision repair cross-complementing rodent repair deficiency, complementation group 5
chr9_+_70012540 0.133 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr5_-_88675190 0.131 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr1_-_127840290 0.124 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr13_-_67451585 0.105 ENSMUST00000057241.8
ENSMUST00000075255.5
Zfp874a

zinc finger protein 874a

chr19_+_8802486 0.101 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr9_+_119341487 0.085 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr6_+_145934113 0.066 ENSMUST00000032383.7
Sspn
sarcospan
chr4_+_145510759 0.063 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chr8_+_114133635 0.059 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr1_-_24612700 0.055 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr4_-_136053343 0.032 ENSMUST00000102536.4
Rpl11
ribosomal protein L11
chr10_-_61784014 0.027 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr4_+_43493345 0.023 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chrX_+_101449078 0.007 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr6_+_65042575 0.007 ENSMUST00000031984.6
Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.4 GO:0019532 oxalate transport(GO:0019532)
0.8 2.4 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.7 2.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.6 2.3 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.6 3.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.5 1.6 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.5 1.5 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 1.4 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.5 2.3 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.4 1.3 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.4 1.7 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.4 1.2 GO:1905223 epicardium morphogenesis(GO:1905223)
0.4 5.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 0.9 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.3 1.4 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 1.2 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.2 0.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.2 2.6 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 0.9 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 0.7 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.2 1.3 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 2.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.2 4.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.7 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 4.2 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.6 GO:0033762 response to glucagon(GO:0033762)
0.1 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.8 GO:0042407 cristae formation(GO:0042407)
0.1 1.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.8 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 0.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.3 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.1 2.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.2 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 1.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.4 GO:0036337 Fas signaling pathway(GO:0036337)
0.1 0.2 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.8 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.8 GO:0006825 copper ion transport(GO:0006825)
0.0 3.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.3 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 1.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.9 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.6 GO:0007530 sex determination(GO:0007530)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 4.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 3.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 2.9 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 0.6 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.4 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 1.7 GO:0000910 cytokinesis(GO:0000910)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.2 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0071438 invadopodium membrane(GO:0071438)
0.3 1.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 0.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 1.2 GO:0070826 paraferritin complex(GO:0070826)
0.2 1.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.2 5.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.8 GO:0061617 MICOS complex(GO:0061617)
0.2 0.5 GO:0036156 inner dynein arm(GO:0036156)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 2.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.3 GO:0032433 filopodium tip(GO:0032433)
0.1 1.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 1.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 3.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 12.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.5 GO:0070469 respiratory chain(GO:0070469)
0.0 1.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
1.0 2.9 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.8 2.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.8 8.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.5 3.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 2.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 1.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.3 2.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 1.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3 1.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.2 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 1.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 0.8 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 5.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.4 GO:0042923 neuropeptide binding(GO:0042923)
0.1 1.3 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 2.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.7 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.4 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 2.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.3 GO:0031489 myosin V binding(GO:0031489)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 1.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 1.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 4.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.9 PID_CXCR4_PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 7.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 2.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 5.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 9.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 2.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.3 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.7 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis