Motif ID: Jun

Z-value: 0.501


Transcription factors associated with Jun:

Gene SymbolEntrez IDGene Name
Jun ENSMUSG00000052684.3 Jun

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junmm10_v2_chr4_-_95052188_950522220.262.0e-02Click!


Activity profile for motif Jun.

activity profile for motif Jun


Sorted Z-values histogram for motif Jun

Sorted Z-values for motif Jun



Network of associatons between targets according to the STRING database.



First level regulatory network of Jun

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_139834148 5.904 ENSMUST00000026548.7
 Gpr123
G protein-coupled receptor 123
chr6_+_17463927 3.607 ENSMUST00000115442.1
 Met
met proto-oncogene
chr2_-_77703252 3.540 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr3_+_109573907 3.383 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr3_-_88503187 2.905 ENSMUST00000120377.1
 Lmna
lamin A
chr6_+_17463749 2.656 ENSMUST00000115443.1
 Met
met proto-oncogene
chr2_+_25395866 2.426 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr15_-_97767798 2.415 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr10_-_76725978 2.388 ENSMUST00000001147.4
 Col6a1
collagen, type VI, alpha 1
chr3_-_88503331 2.330 ENSMUST00000029699.6
 Lmna
lamin A
chr3_-_85722474 2.296 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr10_+_128933782 2.290 ENSMUST00000099112.2
 Itga7
integrin alpha 7
chr5_-_62766153 2.133 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_31042078 2.123 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
 Fxyd5






FXYD domain-containing ion transport regulator 5






chr17_-_24644933 2.121 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr12_+_75308308 2.020 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr7_-_105482197 2.009 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr7_-_44670820 1.906 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr15_-_97767644 1.905 ENSMUST00000128775.2
ENSMUST00000134885.2
 Rapgef3

Rap guanine nucleotide exchange factor (GEF) 3

chr14_-_79301623 1.905 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.0 5.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.1 4.3 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.0 3.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 3.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.5 3.0 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.1 3.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 2.4 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 2.4 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 2.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.6 2.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 2.3 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 2.2 GO:0000910 cytokinesis(GO:0000910)
0.2 2.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 2.1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 2.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 2.0 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.5 1.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.9 GO:0070584 mitochondrion morphogenesis(GO:0070584) vocalization behavior(GO:0071625)
0.6 1.7 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0009925 basal plasma membrane(GO:0009925)
0.7 5.2 GO:0005638 lamin filament(GO:0005638)
1.1 4.3 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 3.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.0 GO:0002080 acrosomal membrane(GO:0002080)
0.0 2.9 GO:0005581 collagen trimer(GO:0005581)
0.2 2.6 GO:0044754 autolysosome(GO:0044754)
0.8 2.3 GO:0005927 muscle tendon junction(GO:0005927)
0.1 2.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.1 GO:0032420 stereocilium(GO:0032420)
0.3 1.9 GO:0097513 myosin II filament(GO:0097513)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.7 GO:0030315 T-tubule(GO:0030315)
0.0 1.6 GO:0005902 microvillus(GO:0005902)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.1 1.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 1.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.4 GO:0097227 sperm annulus(GO:0097227)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 7.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 5.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 5.1 GO:0003924 GTPase activity(GO:0003924)
0.2 4.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 4.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 3.5 GO:0002039 p53 binding(GO:0002039)
0.2 3.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.0 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.2 2.4 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 2.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.3 GO:0043236 laminin binding(GO:0043236)
0.1 2.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.8 GO:0035497 cAMP response element binding(GO:0035497)
0.6 1.7 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153)
0.4 1.7 GO:0004966 galanin receptor activity(GO:0004966)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 4.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 3.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 2.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 2.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 1.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.9 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.9 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 5.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 4.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.9 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 1.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 0.9 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling