Motif ID: Jun
Z-value: 0.501
Transcription factors associated with Jun:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Jun | ENSMUSG00000052684.3 | Jun |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Jun | mm10_v2_chr4_-_95052188_95052222 | 0.26 | 2.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 7.8 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.1 | 4.3 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 1.0 | 5.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.6 | 2.3 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.6 | 1.7 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 0.5 | 1.6 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.5 | 3.0 | GO:0060161 | positive regulation of dopamine receptor signaling pathway(GO:0060161) |
| 0.5 | 1.9 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.4 | 1.6 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.3 | 1.7 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.3 | 2.4 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
| 0.3 | 0.9 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.3 | 1.3 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.2 | 0.7 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.2 | 2.1 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.2 | 1.6 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.2 | 0.7 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.2 | 0.6 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) |
| 0.2 | 0.6 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 0.2 | 0.6 | GO:0042560 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.2 | 1.4 | GO:0015862 | uridine transport(GO:0015862) |
| 0.2 | 1.4 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.2 | 0.6 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.2 | 0.6 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.2 | 0.6 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.2 | 0.6 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) positive regulation of interleukin-6 biosynthetic process(GO:0045410) |
| 0.2 | 0.6 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.2 | 2.0 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 0.5 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.2 | 0.8 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.2 | 0.8 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.2 | 1.1 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.1 | 0.6 | GO:0042414 | epinephrine metabolic process(GO:0042414) |
| 0.1 | 2.4 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.1 | 0.3 | GO:0002265 | astrocyte activation involved in immune response(GO:0002265) response to norepinephrine(GO:0071873) |
| 0.1 | 0.3 | GO:2000969 | positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 0.1 | 3.4 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.1 | 0.8 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.1 | 0.7 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.1 | 0.4 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) |
| 0.1 | 0.7 | GO:0032329 | serine transport(GO:0032329) |
| 0.1 | 0.8 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.1 | 1.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 0.3 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.1 | 0.8 | GO:0098967 | synaptic vesicle docking(GO:0016081) exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 2.4 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 0.3 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) negative regulation of determination of dorsal identity(GO:2000016) |
| 0.1 | 0.5 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.1 | 0.9 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.1 | 0.9 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 0.4 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.1 | 3.0 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.1 | 0.3 | GO:0046370 | fructose biosynthetic process(GO:0046370) |
| 0.1 | 0.3 | GO:0035844 | positive regulation of polarized epithelial cell differentiation(GO:0030862) cloaca development(GO:0035844) |
| 0.1 | 0.4 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.1 | 2.1 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 1.3 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.1 | 2.3 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.1 | 0.4 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.1 | 1.5 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.1 | 0.6 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.3 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.1 | 0.2 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.1 | 1.9 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) vocalization behavior(GO:0071625) |
| 0.1 | 0.7 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.1 | 0.1 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.0 | 0.3 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 1.3 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.3 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.0 | 0.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.8 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 0.2 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 2.1 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 0.3 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 0.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 1.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 1.0 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.0 | 3.5 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
| 0.0 | 0.4 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.2 | GO:0032876 | regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023) |
| 0.0 | 0.2 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.0 | 2.2 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 0.9 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.8 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.1 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 0.3 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.0 | 0.3 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.0 | 0.6 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 0.0 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.0 | 0.2 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.3 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 1.3 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.4 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 0.1 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 0.4 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.3 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.8 | 0.8 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.8 | 2.3 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.7 | 5.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 1.9 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 1.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.2 | 0.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 0.6 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 0.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.2 | 2.6 | GO:0044754 | autolysosome(GO:0044754) |
| 0.2 | 1.4 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 1.5 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 3.0 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 2.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 8.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.2 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 0.3 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.1 | 0.9 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.6 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 0.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.3 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.1 | 0.4 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.0 | 2.1 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.8 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 2.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.1 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.0 | 0.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.4 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 1.7 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.2 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.6 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.1 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.4 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 7.8 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.6 | 1.7 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
| 0.5 | 4.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.4 | 1.7 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.4 | 1.6 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.4 | 1.6 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.3 | 1.5 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.3 | 0.9 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.3 | 1.1 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 2.4 | GO:0043262 | adenosine-diphosphatase activity(GO:0043262) |
| 0.2 | 1.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.2 | 1.3 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 3.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 0.6 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.2 | 0.8 | GO:0042806 | fucose binding(GO:0042806) |
| 0.2 | 5.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 0.5 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.2 | 4.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.6 | GO:0035240 | dopamine binding(GO:0035240) |
| 0.1 | 1.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.8 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 0.8 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.1 | 3.0 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.1 | 1.8 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.9 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.6 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.3 | GO:0004935 | adrenergic receptor activity(GO:0004935) alpha-adrenergic receptor activity(GO:0004936) |
| 0.1 | 0.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 0.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.3 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 2.1 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.6 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.1 | 2.3 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 2.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 0.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.8 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.2 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.1 | 0.4 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.1 | 0.2 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 1.4 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 0.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.1 | 0.7 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 0.3 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.1 | 2.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.2 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 2.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 3.5 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 1.3 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.1 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.0 | 0.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.1 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.0 | 0.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 0.3 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.7 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 5.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 1.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.7 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 0.1 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.7 | GO:0030551 | cyclic nucleotide binding(GO:0030551) |
| 0.0 | 0.2 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.6 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 1.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.2 | 4.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 3.4 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.1 | 2.3 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.0 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 1.6 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.1 | 1.4 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.9 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.4 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.6 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 1.1 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.5 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.9 | PID_EPO_PATHWAY | EPO signaling pathway |
| 0.0 | 1.5 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.9 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.2 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.7 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.1 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.6 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.2 | 1.3 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 0.7 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 4.3 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 5.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 0.9 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 0.8 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.7 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.6 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.9 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.1 | 1.6 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 0.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 0.8 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.5 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 0.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 0.6 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.9 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.0 | 0.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 2.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.2 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.4 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 2.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 0.3 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.3 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_ILS | Genes involved in Signaling by Interleukins |
| 0.0 | 0.8 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 1.2 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
