Motif ID: Junb_Jund

Z-value: 1.185

Transcription factors associated with Junb_Jund:

Gene SymbolEntrez IDGene Name
Junb ENSMUSG00000052837.5 Junb
Jund ENSMUSG00000071076.5 Jund

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junbmm10_v2_chr8_-_84978709_849787480.351.5e-03Click!
Jundmm10_v2_chr8_+_70697739_706977390.019.1e-01Click!


Activity profile for motif Junb_Jund.

activity profile for motif Junb_Jund


Sorted Z-values histogram for motif Junb_Jund

Sorted Z-values for motif Junb_Jund



Network of associatons between targets according to the STRING database.



First level regulatory network of Junb_Jund

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_155276297 20.215 ENSMUST00000029128.3
 Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr1_-_71653162 14.886 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr14_+_66344369 14.654 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr14_+_66344296 14.106 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr7_-_142095266 13.244 ENSMUST00000039926.3
 Dusp8
dual specificity phosphatase 8
chr1_+_71652837 12.128 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chr9_-_98032983 11.579 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr2_+_143546144 10.417 ENSMUST00000028905.9
 Pcsk2
proprotein convertase subtilisin/kexin type 2
chr4_+_32238950 10.412 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr7_+_139248477 10.110 ENSMUST00000093993.3
ENSMUST00000172136.1
 Pwwp2b

PWWP domain containing 2B

chr2_-_57114970 9.908 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_+_110395041 9.732 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr9_-_20976762 9.613 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr11_-_76571527 9.570 ENSMUST00000072740.6
 Abr
active BCR-related gene
chr4_+_102570065 9.418 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr9_-_98033181 9.259 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr6_-_23248264 9.185 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_+_5861489 8.898 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chrX_+_143664365 8.851 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr6_-_92481343 8.798 ENSMUST00000113445.1
 Prickle2
prickle homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 332 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
2.1 24.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 20.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 18.4 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.7 18.0 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
5.2 15.5 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
5.0 14.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
2.2 13.4 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
1.4 13.0 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
2.1 12.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 11.6 GO:0016567 protein ubiquitination(GO:0016567)
0.5 11.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.9 11.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.8 10.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
3.5 10.4 GO:0030070 insulin processing(GO:0030070)
1.5 10.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.1 10.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 10.0 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.5 9.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.7 9.7 GO:0032486 Rap protein signal transduction(GO:0032486)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 43.1 GO:0014069 postsynaptic density(GO:0014069)
0.0 37.3 GO:0005794 Golgi apparatus(GO:0005794)
1.3 20.2 GO:0044754 autolysosome(GO:0044754)
0.8 19.6 GO:0031430 M band(GO:0031430)
0.1 18.5 GO:0001650 fibrillar center(GO:0001650)
0.2 15.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
5.0 14.9 GO:0005577 fibrinogen complex(GO:0005577)
0.9 13.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 12.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 12.8 GO:0043204 perikaryon(GO:0043204)
0.1 12.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 12.1 GO:0044295 axonal growth cone(GO:0044295)
0.3 11.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 11.6 GO:0005776 autophagosome(GO:0005776)
0.4 9.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 8.9 GO:0043034 costamere(GO:0043034)
0.1 8.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 8.6 GO:0097440 apical dendrite(GO:0097440)
0.2 8.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 8.5 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.9 GO:0015631 tubulin binding(GO:0015631)
0.1 27.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
2.4 19.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.6 18.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.7 17.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 16.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 15.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.0 15.5 GO:0045499 chemorepellent activity(GO:0045499)
0.2 15.2 GO:0015459 potassium channel regulator activity(GO:0015459)
2.5 14.9 GO:0045340 mercury ion binding(GO:0045340)
0.9 14.0 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
1.9 13.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 11.7 GO:0030276 clathrin binding(GO:0030276)
0.1 11.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 11.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.4 11.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.6 11.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.0 10.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.6 10.4 GO:0043008 ATP-dependent protein binding(GO:0043008)
1.2 9.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 25.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.3 16.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 15.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.8 14.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 12.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 12.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.4 11.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 8.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 7.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 7.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 6.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 5.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.7 PID_FOXO_PATHWAY FoxO family signaling
0.2 3.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 3.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 30.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 20.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.9 18.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.1 14.8 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 13.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 13.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 11.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 10.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 8.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 8.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 8.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 8.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 7.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 7.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 7.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 7.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 6.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 5.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 5.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 5.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated