Motif ID: Klf1
Z-value: 2.866

Transcription factors associated with Klf1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Klf1 | ENSMUSG00000054191.7 | Klf1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Klf1 | mm10_v2_chr8_+_84901928_84901992 | -0.50 | 2.8e-06 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 638 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
9.0 | 81.4 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
0.5 | 58.7 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
5.9 | 53.5 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
0.7 | 48.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
4.5 | 45.0 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
3.5 | 38.7 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
2.6 | 36.3 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
0.8 | 32.9 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
3.3 | 32.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
3.0 | 30.1 | GO:0046959 | habituation(GO:0046959) |
0.5 | 28.5 | GO:0030032 | lamellipodium assembly(GO:0030032) |
3.5 | 28.1 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
5.6 | 27.8 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
1.2 | 27.3 | GO:0021681 | cerebellar granular layer development(GO:0021681) |
0.9 | 27.2 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
8.9 | 26.8 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
0.9 | 26.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.7 | 25.7 | GO:0015914 | phospholipid transport(GO:0015914) |
0.8 | 25.4 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
6.2 | 24.7 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 282 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 94.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
1.1 | 89.7 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
8.0 | 80.3 | GO:0045298 | tubulin complex(GO:0045298) |
0.3 | 66.0 | GO:0000139 | Golgi membrane(GO:0000139) |
0.9 | 65.6 | GO:0005581 | collagen trimer(GO:0005581) |
1.4 | 65.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
16.1 | 64.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
0.4 | 59.5 | GO:0099572 | postsynaptic specialization(GO:0099572) |
0.5 | 55.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
0.8 | 42.5 | GO:0031941 | filamentous actin(GO:0031941) |
2.4 | 41.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
1.6 | 40.4 | GO:0071565 | nBAF complex(GO:0071565) |
13.2 | 39.7 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
0.5 | 39.7 | GO:0043204 | perikaryon(GO:0043204) |
3.4 | 37.2 | GO:0032426 | stereocilium tip(GO:0032426) |
1.3 | 36.4 | GO:0032590 | dendrite membrane(GO:0032590) |
1.8 | 36.0 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
0.7 | 33.5 | GO:0016235 | aggresome(GO:0016235) |
1.7 | 33.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
10.9 | 32.8 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 403 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
11.3 | 78.9 | GO:0099609 | microtubule lateral binding(GO:0099609) |
0.3 | 72.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
16.1 | 64.2 | GO:0031720 | haptoglobin binding(GO:0031720) |
0.8 | 53.3 | GO:0030276 | clathrin binding(GO:0030276) |
6.8 | 47.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.2 | 46.7 | GO:0003924 | GTPase activity(GO:0003924) |
2.6 | 44.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.4 | 43.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.6 | 42.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.9 | 41.0 | GO:0015485 | cholesterol binding(GO:0015485) |
0.8 | 40.4 | GO:0005267 | potassium channel activity(GO:0005267) |
2.1 | 39.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
9.6 | 38.5 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
2.7 | 37.4 | GO:0031005 | filamin binding(GO:0031005) |
0.7 | 33.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
2.7 | 32.4 | GO:0070097 | delta-catenin binding(GO:0070097) |
2.5 | 32.1 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
4.5 | 31.7 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.6 | 31.7 | GO:0005262 | calcium channel activity(GO:0005262) |
0.6 | 30.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 82 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.6 | 87.3 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
1.5 | 76.9 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.7 | 54.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.3 | 48.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
1.3 | 47.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.8 | 45.1 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.9 | 42.1 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
2.4 | 41.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.8 | 32.6 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
1.7 | 29.0 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.5 | 24.6 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.5 | 19.7 | PID_SHP2_PATHWAY | SHP2 signaling |
0.1 | 19.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.6 | 16.1 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
0.5 | 14.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
1.3 | 14.4 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
0.4 | 13.4 | PID_BCR_5PATHWAY | BCR signaling pathway |
0.1 | 12.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.8 | 12.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.5 | 12.6 | PID_REELIN_PATHWAY | Reelin signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 149 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 95.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
3.9 | 90.5 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
1.6 | 66.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.8 | 64.1 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
2.1 | 57.5 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.8 | 51.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
1.2 | 39.1 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
1.0 | 37.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
1.1 | 34.1 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
4.7 | 33.1 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.9 | 31.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
1.5 | 30.4 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
1.3 | 29.5 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
1.2 | 29.1 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
1.1 | 29.0 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
1.1 | 28.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
1.3 | 26.9 | REACTOME_INWARDLY_RECTIFYING_K_CHANNELS | Genes involved in Inwardly rectifying K+ channels |
2.5 | 25.1 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
2.5 | 24.8 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
1.8 | 24.8 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |