Motif ID: Klf1

Z-value: 2.866


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.502.8e-06Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103813913 42.038 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr6_+_5725639 39.722 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr5_-_139325616 39.312 ENSMUST00000110865.1
Adap1
ArfGAP with dual PH domains 1
chr4_+_47208005 38.383 ENSMUST00000082303.6
ENSMUST00000102917.4
Col15a1

collagen, type XV, alpha 1

chr12_+_108334341 32.599 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr15_+_83791939 28.750 ENSMUST00000172115.1
ENSMUST00000172398.1
Mpped1

metallophosphoesterase domain containing 1

chr19_+_4099998 28.633 ENSMUST00000049658.7
Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr12_-_4841583 28.135 ENSMUST00000020964.5
Fkbp1b
FK506 binding protein 1b
chr7_+_44310213 27.980 ENSMUST00000107938.1
Shank1
SH3/ankyrin domain gene 1
chr2_-_162661075 27.869 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
Ptprt



protein tyrosine phosphatase, receptor type, T



chr17_-_26201328 27.509 ENSMUST00000025019.2
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr8_+_93810832 27.377 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr14_+_70554056 26.303 ENSMUST00000022691.7
Hr
hairless
chr15_-_37791993 26.236 ENSMUST00000168992.1
ENSMUST00000148652.1
Ncald

neurocalcin delta

chr9_-_107710475 26.177 ENSMUST00000080560.3
Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr5_+_130448801 25.663 ENSMUST00000111288.2
Caln1
calneuron 1
chr10_-_81025521 25.075 ENSMUST00000144640.1
Diras1
DIRAS family, GTP-binding RAS-like 1
chr11_+_120721452 23.559 ENSMUST00000018156.5
Rac3
RAS-related C3 botulinum substrate 3
chr11_+_62575981 23.365 ENSMUST00000102643.1
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_104231465 22.726 ENSMUST00000145227.1
Mapt
microtubule-associated protein tau

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 638 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.0 81.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.5 58.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
5.9 53.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.7 48.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.5 45.0 GO:0010459 negative regulation of heart rate(GO:0010459)
3.5 38.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.6 36.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.8 32.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
3.3 32.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
3.0 30.1 GO:0046959 habituation(GO:0046959)
0.5 28.5 GO:0030032 lamellipodium assembly(GO:0030032)
3.5 28.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
5.6 27.8 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
1.2 27.3 GO:0021681 cerebellar granular layer development(GO:0021681)
0.9 27.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
8.9 26.8 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.9 26.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.7 25.7 GO:0015914 phospholipid transport(GO:0015914)
0.8 25.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
6.2 24.7 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 282 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 94.7 GO:0045211 postsynaptic membrane(GO:0045211)
1.1 89.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
8.0 80.3 GO:0045298 tubulin complex(GO:0045298)
0.3 66.0 GO:0000139 Golgi membrane(GO:0000139)
0.9 65.6 GO:0005581 collagen trimer(GO:0005581)
1.4 65.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
16.1 64.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 59.5 GO:0099572 postsynaptic specialization(GO:0099572)
0.5 55.9 GO:0070382 exocytic vesicle(GO:0070382)
0.8 42.5 GO:0031941 filamentous actin(GO:0031941)
2.4 41.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.6 40.4 GO:0071565 nBAF complex(GO:0071565)
13.2 39.7 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.5 39.7 GO:0043204 perikaryon(GO:0043204)
3.4 37.2 GO:0032426 stereocilium tip(GO:0032426)
1.3 36.4 GO:0032590 dendrite membrane(GO:0032590)
1.8 36.0 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.7 33.5 GO:0016235 aggresome(GO:0016235)
1.7 33.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
10.9 32.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 403 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.3 78.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 72.1 GO:0005096 GTPase activator activity(GO:0005096)
16.1 64.2 GO:0031720 haptoglobin binding(GO:0031720)
0.8 53.3 GO:0030276 clathrin binding(GO:0030276)
6.8 47.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 46.7 GO:0003924 GTPase activity(GO:0003924)
2.6 44.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 43.9 GO:0030165 PDZ domain binding(GO:0030165)
0.6 42.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 41.0 GO:0015485 cholesterol binding(GO:0015485)
0.8 40.4 GO:0005267 potassium channel activity(GO:0005267)
2.1 39.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
9.6 38.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
2.7 37.4 GO:0031005 filamin binding(GO:0031005)
0.7 33.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
2.7 32.4 GO:0070097 delta-catenin binding(GO:0070097)
2.5 32.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
4.5 31.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.6 31.7 GO:0005262 calcium channel activity(GO:0005262)
0.6 30.7 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 87.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
1.5 76.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.7 54.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 48.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.3 47.2 PID_ARF6_PATHWAY Arf6 signaling events
0.8 45.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.9 42.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
2.4 41.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.8 32.6 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
1.7 29.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.5 24.6 PID_INSULIN_PATHWAY Insulin Pathway
0.5 19.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 19.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 16.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.5 14.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.3 14.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.4 13.4 PID_BCR_5PATHWAY BCR signaling pathway
0.1 12.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8 12.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.5 12.6 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 95.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
3.9 90.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.6 66.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.8 64.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
2.1 57.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.8 51.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.2 39.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
1.0 37.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.1 34.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
4.7 33.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.9 31.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.5 30.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.3 29.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
1.2 29.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.1 29.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
1.1 28.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
1.3 26.9 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
2.5 25.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
2.5 24.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
1.8 24.8 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression