Motif ID: Klf12_Klf14_Sp4

Z-value: 1.420

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12mm10_v2_chr14_-_100149764_1001497640.351.6e-03Click!
Sp4mm10_v2_chr12_-_118301429_1183014580.037.9e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_99252839 20.257 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr15_+_25622525 18.166 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr9_+_80165079 18.072 ENSMUST00000184480.1
 Myo6
myosin VI
chr14_+_60634719 17.165 ENSMUST00000022566.7
ENSMUST00000159729.1
 Spata13

spermatogenesis associated 13

chr9_+_80165013 16.614 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr15_-_58076456 15.532 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr5_-_140389188 13.725 ENSMUST00000031539.7
 Snx8
sorting nexin 8
chr4_+_137468767 12.721 ENSMUST00000030547.8
ENSMUST00000171332.1
 Hspg2

perlecan (heparan sulfate proteoglycan 2)

chr17_+_57249450 11.365 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chr7_+_107595051 10.609 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr18_+_64340225 10.339 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr11_+_62077018 10.259 ENSMUST00000092415.5
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr13_-_49215978 9.742 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr2_+_172345565 9.507 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr5_-_115119277 9.426 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr13_+_92611119 9.156 ENSMUST00000049488.7
 Serinc5
serine incorporator 5
chr11_-_69948145 8.856 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr15_-_32244632 8.721 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr2_+_79635352 8.600 ENSMUST00000111785.2
 Ssfa2
sperm specific antigen 2
chr2_+_79635416 8.001 ENSMUST00000111788.1
 Ssfa2
sperm specific antigen 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 706 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 28.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
1.3 16.4 GO:0001675 acrosome assembly(GO:0001675)
1.8 15.8 GO:0042538 hyperosmotic salinity response(GO:0042538)
4.5 13.5 GO:0006601 creatine biosynthetic process(GO:0006601)
1.5 13.5 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.3 13.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.9 12.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
1.1 12.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
2.9 11.8 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 11.3 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
1.0 11.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.9 10.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.3 10.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.2 9.9 GO:0033700 phospholipid efflux(GO:0033700)
0.7 9.8 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.6 9.7 GO:0035493 SNARE complex assembly(GO:0035493)
1.1 9.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.5 9.2 GO:0002115 store-operated calcium entry(GO:0002115)
2.1 8.5 GO:0009597 detection of virus(GO:0009597)
0.1 8.5 GO:0046847 filopodium assembly(GO:0046847)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 269 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 47.5 GO:0030175 filopodium(GO:0030175)
0.0 37.2 GO:0005615 extracellular space(GO:0005615)
0.9 24.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 22.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 20.0 GO:0001726 ruffle(GO:0001726)
0.9 18.3 GO:0002080 acrosomal membrane(GO:0002080)
0.1 16.2 GO:0000790 nuclear chromatin(GO:0000790)
0.7 15.0 GO:0005605 basal lamina(GO:0005605)
0.8 12.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 12.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 12.8 GO:0005814 centriole(GO:0005814)
0.4 12.0 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
1.1 11.3 GO:0000796 condensin complex(GO:0000796)
0.4 11.3 GO:0030904 retromer complex(GO:0030904)
0.2 10.7 GO:0045171 intercellular bridge(GO:0045171)
0.2 10.7 GO:0031519 PcG protein complex(GO:0031519)
1.0 9.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.5 9.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
1.8 8.9 GO:0097149 centralspindlin complex(GO:0097149)
0.6 8.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 416 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 92.7 GO:0051015 actin filament binding(GO:0051015)
0.2 31.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 25.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.5 15.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 14.9 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 14.1 GO:0004540 ribonuclease activity(GO:0004540)
0.4 13.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.3 11.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 11.9 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
2.8 11.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.8 10.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
1.7 10.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 9.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3 9.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.7 8.7 GO:0044548 S100 protein binding(GO:0044548)
0.4 8.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 8.6 GO:0071837 HMG box domain binding(GO:0071837)
0.1 8.6 GO:0002020 protease binding(GO:0002020)
0.6 8.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
2.7 8.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 46.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 24.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.5 22.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 18.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.9 16.2 ST_STAT3_PATHWAY STAT3 Pathway
0.3 15.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.4 15.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 13.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 12.7 PID_BMP_PATHWAY BMP receptor signaling
0.3 12.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 11.1 PID_E2F_PATHWAY E2F transcription factor network
0.3 10.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 9.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.6 7.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 7.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 6.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 5.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.3 5.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 5.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.0 19.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 17.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
1.0 16.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 14.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.7 14.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.5 13.9 REACTOME_KINESINS Genes involved in Kinesins
1.0 13.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.1 13.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.6 11.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 11.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 9.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.5 9.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 8.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 7.8 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.2 7.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 7.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 7.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 7.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 6.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions