Motif ID: Klf15

Z-value: 0.931


Transcription factors associated with Klf15:

Gene SymbolEntrez IDGene Name
Klf15 ENSMUSG00000030087.5 Klf15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf15mm10_v2_chr6_+_90465287_904653040.575.1e-08Click!


Activity profile for motif Klf15.

activity profile for motif Klf15


Sorted Z-values histogram for motif Klf15

Sorted Z-values for motif Klf15



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 16.597 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr18_-_66291770 11.957 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr18_-_89769479 11.488 ENSMUST00000097495.3
 Dok6
docking protein 6
chr5_+_130448801 9.500 ENSMUST00000111288.2
 Caln1
calneuron 1
chr1_-_56972437 9.429 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr6_-_148444336 8.803 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr3_+_117575268 8.635 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr17_+_46297917 6.860 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr5_+_137288273 6.086 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr10_-_54075730 5.857 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha

chrX_-_136868537 5.738 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr4_+_129985098 5.696 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr3_+_118433797 5.376 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr2_-_5714490 5.374 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr11_+_50602072 5.348 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr18_+_32938955 5.347 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr1_-_168431896 5.302 ENSMUST00000176540.1
 Pbx1
pre B cell leukemia homeobox 1
chr11_+_69765970 5.270 ENSMUST00000108642.1
ENSMUST00000156932.1
 Zbtb4

zinc finger and BTB domain containing 4

chr3_+_117575227 5.041 ENSMUST00000106473.2
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr2_+_140395309 5.021 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
 Macrod2





MACRO domain containing 2






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 26.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 12.5 GO:0030325 adrenal gland development(GO:0030325)
3.0 12.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
2.0 12.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 10.4 GO:0006491 N-glycan processing(GO:0006491)
2.0 8.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.3 7.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
1.1 7.9 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.2 6.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 6.1 GO:0019695 choline metabolic process(GO:0019695)
0.1 5.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.2 5.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.8 5.4 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 5.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 5.3 GO:0030574 collagen catabolic process(GO:0030574)
0.6 4.9 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 4.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.5 4.4 GO:0060596 mammary placode formation(GO:0060596)
1.5 4.4 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.4 4.4 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 11.5 GO:0005581 collagen trimer(GO:0005581)
0.1 10.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 10.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 9.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 9.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 7.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 6.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 6.4 GO:0001650 fibrillar center(GO:0001650)
0.4 6.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 5.8 GO:0030175 filopodium(GO:0030175)
0.1 5.7 GO:0045335 phagocytic vesicle(GO:0045335)
1.8 5.5 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 5.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.3 GO:0005795 Golgi stack(GO:0005795)
0.0 4.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.8 4.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 3.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.2 3.7 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 12.0 GO:0005518 collagen binding(GO:0005518)
0.2 11.5 GO:0005158 insulin receptor binding(GO:0005158)
1.1 10.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.4 9.3 GO:0008327 methyl-CpG binding(GO:0008327)
1.0 7.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 7.2 GO:0019213 deacetylase activity(GO:0019213)
0.2 6.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.5 6.1 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 5.7 GO:0019003 GDP binding(GO:0019003)
0.0 5.6 GO:0017124 SH3 domain binding(GO:0017124)
0.5 5.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 5.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 4.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 4.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.5 4.4 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.4 4.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 4.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 4.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 4.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 11.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 11.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.3 9.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 6.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 5.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.2 4.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 4.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 4.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.9 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 9.2 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.1 6.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 6.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 5.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 4.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 4.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 3.8 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 3.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 3.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 3.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 3.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.5 2.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 2.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 1.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates