Motif ID: Klf3

Z-value: 0.321


Transcription factors associated with Klf3:

Gene SymbolEntrez IDGene Name
Klf3 ENSMUSG00000029178.8 Klf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64812336_64812350-0.333.3e-03Click!


Activity profile for motif Klf3.

activity profile for motif Klf3


Sorted Z-values histogram for motif Klf3

Sorted Z-values for motif Klf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_107511489 1.430 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.366 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_72824482 1.352 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr7_+_82337218 1.149 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr12_+_87026286 0.974 ENSMUST00000146292.1
 Tmem63c
transmembrane protein 63c
chr12_+_87026564 0.948 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr7_-_103827922 0.911 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr3_+_135438722 0.654 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_-_4149781 0.585 ENSMUST00000058358.6
 Leng9
leukocyte receptor cluster (LRC) member 9
chr11_+_68968107 0.507 ENSMUST00000102606.3
ENSMUST00000018884.5
 Slc25a35

solute carrier family 25, member 35

chrX_-_102251852 0.499 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chrX_-_102252154 0.455 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr3_+_90080442 0.448 ENSMUST00000127955.1
 Tpm3
tropomyosin 3, gamma
chr3_+_90079540 0.400 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
 Tpm3


tropomyosin 3, gamma


chr19_+_10041548 0.373 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr9_-_95815389 0.345 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chrX_+_7884321 0.267 ENSMUST00000096514.3
ENSMUST00000123277.1
 Slc35a2

solute carrier family 35 (UDP-galactose transporter), member A2

chr9_-_67539392 0.262 ENSMUST00000039662.8
 Tln2
talin 2
chr3_-_89089955 0.258 ENSMUST00000166687.1
 Rusc1
RUN and SH3 domain containing 1
chr5_+_124541296 0.239 ENSMUST00000124529.1
 Tmed2
transmembrane emp24 domain trafficking protein 2
chrX_-_74246534 0.196 ENSMUST00000101454.2
ENSMUST00000033699.6
 Flna

filamin, alpha

chr1_+_131867224 0.186 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr3_+_89266552 0.175 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr1_+_86064619 0.159 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr15_-_102722150 0.157 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr13_-_74292297 0.155 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor

chr15_-_102722120 0.078 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr19_-_53390559 0.069 ENSMUST00000025997.5
 Smndc1
survival motor neuron domain containing 1
chr5_+_137630116 0.065 ENSMUST00000175968.1
 Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chrX_-_74246364 0.054 ENSMUST00000130007.1
 Flna
filamin, alpha
chr11_-_97500340 0.046 ENSMUST00000056955.1
 4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr7_-_17027853 0.045 ENSMUST00000003183.5
 Ppp5c
protein phosphatase 5, catalytic subunit
chr10_+_93488766 0.043 ENSMUST00000129421.1
 Hal
histidine ammonia lyase
chr3_-_89960562 0.023 ENSMUST00000069805.7
 Atp8b2
ATPase, class I, type 8B, member 2
chr7_-_17027807 0.006 ENSMUST00000142597.1
 Ppp5c
protein phosphatase 5, catalytic subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 0.3 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 0.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 1.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 2.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.0 GO:0006547 histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.1 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 1.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis