Motif ID: Klf4_Sp3

Z-value: 1.214

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.262.1e-02Click!
Klf4mm10_v2_chr4_-_55532453_55532485-0.208.3e-02Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127534540 25.746 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr8_+_87473116 20.673 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr7_+_29289300 18.636 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr11_+_101468164 14.219 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr5_-_113908685 13.695 ENSMUST00000004646.6
 Coro1c
coronin, actin binding protein 1C
chr1_-_172057573 13.202 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr8_+_87472805 12.757 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr3_-_8667033 12.689 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr8_+_105518736 12.338 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr8_+_87472838 11.458 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr11_-_76399107 10.499 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr4_-_117133953 10.393 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr4_-_135272798 10.334 ENSMUST00000037099.8
 Clic4
chloride intracellular channel 4 (mitochondrial)
chr9_+_123478693 10.213 ENSMUST00000026269.2
 Limd1
LIM domains containing 1
chr7_+_80294450 10.056 ENSMUST00000163812.2
ENSMUST00000047558.7
ENSMUST00000174199.1
ENSMUST00000173824.1
ENSMUST00000174172.1
 Prc1




protein regulator of cytokinesis 1




chr6_+_120666388 9.797 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr1_-_175692624 9.779 ENSMUST00000027809.7
 Opn3
opsin 3
chr4_-_107923519 9.718 ENSMUST00000106719.1
ENSMUST00000106720.2
ENSMUST00000131644.1
ENSMUST00000030345.8
 Cpt2



carnitine palmitoyltransferase 2



chr2_+_168081004 9.521 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr18_-_34007206 9.418 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 26.3 GO:0038092 nodal signaling pathway(GO:0038092)
3.4 24.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.5 22.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.0 21.6 GO:0044458 motile cilium assembly(GO:0044458)
0.9 20.4 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
2.0 17.8 GO:0001842 neural fold formation(GO:0001842)
1.6 17.3 GO:0003263 cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264)
0.5 16.7 GO:0006284 base-excision repair(GO:0006284)
2.4 16.6 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.6 15.3 GO:0034508 centromere complex assembly(GO:0034508)
3.0 15.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.8 15.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.6 14.7 GO:0051310 metaphase plate congression(GO:0051310)
1.8 14.6 GO:1990845 adaptive thermogenesis(GO:1990845)
1.3 14.6 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.5 14.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 14.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.0 14.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.1 14.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
1.1 14.2 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 395 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 92.2 GO:0005634 nucleus(GO:0005634)
0.1 72.1 GO:0005739 mitochondrion(GO:0005739)
0.1 38.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 36.6 GO:0005667 transcription factor complex(GO:0005667)
0.4 27.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 25.5 GO:0000922 spindle pole(GO:0000922)
0.4 23.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 20.9 GO:0030496 midbody(GO:0030496)
0.4 19.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 18.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.8 18.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 17.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 16.9 GO:0070469 respiratory chain(GO:0070469)
0.1 16.7 GO:0000790 nuclear chromatin(GO:0000790)
0.3 15.7 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.2 14.9 GO:0072562 blood microparticle(GO:0072562)
0.9 14.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.4 14.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.7 14.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.3 13.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 609 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 67.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 32.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.7 31.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 27.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 27.0 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.1 25.6 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.7 25.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 25.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
4.0 20.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.4 19.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.5 19.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 19.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
1.2 17.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 17.5 GO:0070410 co-SMAD binding(GO:0070410)
0.3 16.2 GO:0061135 endopeptidase regulator activity(GO:0061135)
0.4 16.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.6 15.4 GO:0003785 actin monomer binding(GO:0003785)
0.3 15.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 14.9 GO:0050699 WW domain binding(GO:0050699)
0.3 14.8 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 53.7 PID_PLK1_PATHWAY PLK1 signaling events
0.5 51.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 48.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.7 32.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
2.3 32.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 31.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.8 30.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.6 25.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.5 25.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 23.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.7 20.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.6 20.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 19.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 18.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 16.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 16.0 PID_E2F_PATHWAY E2F transcription factor network
0.4 13.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.6 12.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 11.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 11.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 54.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 50.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 49.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 46.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.3 35.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.7 28.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 27.8 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.4 25.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
1.2 24.6 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.9 23.4 REACTOME_KINESINS Genes involved in Kinesins
0.6 22.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.8 22.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 19.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 17.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 16.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.7 15.0 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.5 13.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
1.0 13.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 13.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 13.7 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC