Motif ID: Klf7

Z-value: 0.431


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.315.3e-03Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_897782 6.983 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_-_138847579 4.639 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_172550991 3.301 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_119047116 3.159 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_119047129 2.769 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr15_+_99074968 2.618 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr9_-_32344237 2.031 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr5_+_33658123 1.922 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr5_+_137761680 1.752 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4

chr2_-_151973387 1.715 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr12_-_4592927 1.431 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr18_+_35118880 1.208 ENSMUST00000042345.6
 Ctnna1
catenin (cadherin associated protein), alpha 1
chr1_+_167689108 1.198 ENSMUST00000111377.1
 Lmx1a
LIM homeobox transcription factor 1 alpha
chr10_+_79682169 1.141 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr13_+_21722057 1.030 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr11_-_40733373 1.023 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chrX_+_136270253 0.950 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr5_+_140607334 0.940 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_87230435 0.905 ENSMUST00000107157.2
 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr5_-_136135989 0.894 ENSMUST00000150406.1
ENSMUST00000006301.4
 Lrwd1

leucine-rich repeats and WD repeat domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 7.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.9 4.6 GO:0035262 gonad morphogenesis(GO:0035262)
1.1 3.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.4 2.0 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.9 GO:0030953 astral microtubule organization(GO:0030953)
0.2 1.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.5 1.4 GO:0036090 cleavage furrow ingression(GO:0036090)
0.3 1.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 1.2 GO:0042048 olfactory behavior(GO:0042048)
0.1 1.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.9 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.8 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 0.6 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.2 0.6 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.6 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0030315 voltage-gated potassium channel complex(GO:0008076) T-tubule(GO:0030315)
0.1 1.4 GO:0070938 contractile ring(GO:0070938)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.1 0.9 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.8 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.2 0.6 GO:1990047 spindle matrix(GO:1990047)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.0 GO:0097543 ciliary inversin compartment(GO:0097543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 2.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 0.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 0.9 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 0.9 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)