Motif ID: Klf8

Z-value: 0.538


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.342.7e-03Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_127026479 2.318 ENSMUST00000032916.4
Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr19_+_5740885 2.314 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr14_+_28511344 2.270 ENSMUST00000112272.1
Wnt5a
wingless-related MMTV integration site 5A
chr16_+_30599717 1.697 ENSMUST00000059078.3
Fam43a
family with sequence similarity 43, member A
chr11_+_69632927 1.696 ENSMUST00000018909.3
Fxr2
fragile X mental retardation, autosomal homolog 2
chr1_-_20820213 1.685 ENSMUST00000053266.9
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr17_-_70851189 1.602 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr17_+_34898931 1.592 ENSMUST00000097342.3
ENSMUST00000013931.5
Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr2_-_36105271 1.553 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
Lhx6


LIM homeobox protein 6


chrX_+_161717055 1.549 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chr3_+_90541146 1.396 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
S100a16


S100 calcium binding protein A16


chr11_-_32222233 1.363 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 1.299 ENSMUST00000168120.1
Acot1
acyl-CoA thioesterase 1
chr13_+_49187485 1.297 ENSMUST00000049022.8
ENSMUST00000120733.1
Ninj1

ninjurin 1

chr7_-_142657466 1.266 ENSMUST00000097936.2
ENSMUST00000000033.5
Igf2

insulin-like growth factor 2

chr7_+_100495987 1.254 ENSMUST00000133044.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chrX_+_96096034 1.226 ENSMUST00000117399.1
Msn
moesin
chr5_+_139423151 1.218 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr1_+_172499948 1.202 ENSMUST00000111230.1
Tagln2
transgelin 2
chr2_+_179893909 1.197 ENSMUST00000098996.1
Gm10711
predicted gene 10711
chr15_+_78926720 1.180 ENSMUST00000089377.5
Lgals1
lectin, galactose binding, soluble 1
chr4_-_155043143 1.149 ENSMUST00000135665.2
Plch2
phospholipase C, eta 2
chr13_-_55488038 1.121 ENSMUST00000109921.2
ENSMUST00000109923.2
ENSMUST00000021950.8
Dbn1


drebrin 1


chr2_+_27886416 1.106 ENSMUST00000028280.7
Col5a1
collagen, type V, alpha 1
chr19_+_25610533 1.083 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr10_-_84440591 1.067 ENSMUST00000020220.8
Nuak1
NUAK family, SNF1-like kinase, 1
chr19_+_7268296 1.064 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr7_+_110627650 1.061 ENSMUST00000033054.8
Adm
adrenomedullin
chr6_+_115134899 1.059 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr7_-_139582790 1.052 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr1_-_184883218 1.051 ENSMUST00000048308.5
C130074G19Rik
RIKEN cDNA C130074G19 gene
chr10_+_116301374 1.048 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr10_-_127666598 1.004 ENSMUST00000099157.3
Nab2
Ngfi-A binding protein 2
chr19_+_6975048 0.993 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_-_119093468 0.985 ENSMUST00000010804.2
Plcd1
phospholipase C, delta 1
chr6_-_72788952 0.976 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_+_16843049 0.973 ENSMUST00000086104.4
Prkd2
protein kinase D2
chr2_+_156840077 0.946 ENSMUST00000081335.6
ENSMUST00000073352.3
Tgif2

TGFB-induced factor homeobox 2

chr15_-_89355655 0.936 ENSMUST00000023283.5
Lmf2
lipase maturation factor 2
chr11_-_35980473 0.922 ENSMUST00000018993.6
Wwc1
WW, C2 and coiled-coil domain containing 1
chr17_-_45549655 0.905 ENSMUST00000180252.1
Tmem151b
transmembrane protein 151B
chr17_+_34898463 0.904 ENSMUST00000114033.2
ENSMUST00000078061.6
Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr7_-_31055594 0.901 ENSMUST00000039909.6
Fxyd1
FXYD domain-containing ion transport regulator 1
chr1_+_36511867 0.887 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr14_-_103843685 0.886 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr4_+_46450892 0.881 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_+_19004047 0.878 ENSMUST00000053713.3
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr10_-_80399478 0.869 ENSMUST00000092295.3
ENSMUST00000105349.1
Mbd3

methyl-CpG binding domain protein 3

chr7_+_16842896 0.863 ENSMUST00000168093.2
Prkd2
protein kinase D2
chr18_-_78206408 0.861 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr9_-_8004585 0.861 ENSMUST00000086580.5
ENSMUST00000065353.6
Yap1

yes-associated protein 1

chr11_-_69948145 0.859 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr17_-_57247632 0.856 ENSMUST00000005975.6
Gpr108
G protein-coupled receptor 108
chr15_-_83149307 0.851 ENSMUST00000100375.4
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr3_-_89393294 0.842 ENSMUST00000142119.1
ENSMUST00000029677.8
ENSMUST00000148361.1
Zbtb7b


zinc finger and BTB domain containing 7B


chr2_+_30416096 0.834 ENSMUST00000113601.3
ENSMUST00000113603.3
Ppp2r4

protein phosphatase 2A, regulatory subunit B (PR 53)

chr2_+_30416031 0.822 ENSMUST00000042055.3
Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chrX_+_161717498 0.822 ENSMUST00000061514.7
Rai2
retinoic acid induced 2
chr10_+_96616998 0.808 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr9_+_58134535 0.805 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
Stra6



stimulated by retinoic acid gene 6



chr11_+_114765363 0.803 ENSMUST00000138804.1
ENSMUST00000084368.5
Kif19a

kinesin family member 19A

chr17_-_27820445 0.799 ENSMUST00000114859.1
D17Wsu92e
DNA segment, Chr 17, Wayne State University 92, expressed
chr14_-_8666236 0.790 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr1_+_92831614 0.789 ENSMUST00000045970.6
Gpc1
glypican 1
chr7_-_31054815 0.786 ENSMUST00000071697.4
ENSMUST00000108110.3
Fxyd1

FXYD domain-containing ion transport regulator 1

chr7_+_112427706 0.761 ENSMUST00000033030.7
Parva
parvin, alpha
chr5_-_114690974 0.757 ENSMUST00000012028.7
Gltp
glycolipid transfer protein
chr7_-_93081027 0.753 ENSMUST00000098303.1
Gm9934
predicted gene 9934
chr4_+_148160613 0.753 ENSMUST00000047951.8
Fbxo2
F-box protein 2
chr1_+_192190771 0.743 ENSMUST00000078470.5
ENSMUST00000110844.1
Kcnh1

potassium voltage-gated channel, subfamily H (eag-related), member 1

chr7_-_31042078 0.739 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
Fxyd5






FXYD domain-containing ion transport regulator 5






chr17_-_27820534 0.736 ENSMUST00000075076.4
ENSMUST00000114863.2
D17Wsu92e

DNA segment, Chr 17, Wayne State University 92, expressed

chrX_-_73921917 0.733 ENSMUST00000114389.3
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr11_+_114851814 0.730 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
Gprc5c


G protein-coupled receptor, family C, group 5, member C


chr11_-_101466222 0.729 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr19_-_7105729 0.721 ENSMUST00000113383.2
Flrt1
fibronectin leucine rich transmembrane protein 1
chr15_+_78406695 0.711 ENSMUST00000167140.1
Mpst
mercaptopyruvate sulfurtransferase
chr7_+_144838590 0.708 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chrX_+_56963325 0.698 ENSMUST00000096431.3
Gpr112
G protein-coupled receptor 112
chr7_+_4119525 0.697 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr2_+_29619692 0.696 ENSMUST00000095087.4
ENSMUST00000091146.5
ENSMUST00000102872.4
Rapgef1


Rap guanine nucleotide exchange factor (GEF) 1


chr1_-_186705980 0.691 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr2_-_165473187 0.689 ENSMUST00000029208.8
ENSMUST00000109279.2
Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr7_-_27355944 0.684 ENSMUST00000003857.6
Shkbp1
Sh3kbp1 binding protein 1
chr11_-_5261558 0.680 ENSMUST00000020662.8
Kremen1
kringle containing transmembrane protein 1
chr13_-_60177357 0.679 ENSMUST00000065086.4
Gas1
growth arrest specific 1
chr9_+_66158206 0.665 ENSMUST00000034944.2
Dapk2
death-associated protein kinase 2
chr15_+_78406777 0.665 ENSMUST00000169133.1
Mpst
mercaptopyruvate sulfurtransferase
chr3_+_87906321 0.664 ENSMUST00000005017.8
Hdgf
hepatoma-derived growth factor
chr7_+_4119556 0.661 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr1_-_75505641 0.659 ENSMUST00000155084.1
Obsl1
obscurin-like 1
chr11_-_116654245 0.656 ENSMUST00000021166.5
Cygb
cytoglobin
chr16_-_18811615 0.651 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chrX_-_73921828 0.645 ENSMUST00000096316.3
ENSMUST00000114390.1
ENSMUST00000114391.3
ENSMUST00000114387.1
Naa10



N(alpha)-acetyltransferase 10, NatA catalytic subunit



chr7_-_63938862 0.644 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr15_-_97767644 0.641 ENSMUST00000128775.2
ENSMUST00000134885.2
Rapgef3

Rap guanine nucleotide exchange factor (GEF) 3

chrX_-_73921930 0.636 ENSMUST00000033763.8
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr12_-_57546121 0.635 ENSMUST00000044380.6
Foxa1
forkhead box A1
chr3_+_94377432 0.634 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr2_-_168590315 0.629 ENSMUST00000109184.1
Nfatc2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
chr15_+_39006272 0.624 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr2_-_168741898 0.624 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr12_-_69228167 0.622 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr4_-_136602641 0.609 ENSMUST00000105847.1
ENSMUST00000116273.2
Kdm1a

lysine (K)-specific demethylase 1A

chr15_+_81744848 0.603 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr16_+_93683184 0.600 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr1_-_172027269 0.596 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_+_146500071 0.592 ENSMUST00000119130.1
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr8_+_110721462 0.589 ENSMUST00000052457.8
Mtss1l
metastasis suppressor 1-like
chr11_-_69801716 0.588 ENSMUST00000011285.4
ENSMUST00000102585.1
Fgf11

fibroblast growth factor 11

chr6_+_85187438 0.587 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr4_-_150914401 0.585 ENSMUST00000105675.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr7_+_24884611 0.585 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr11_+_70647258 0.580 ENSMUST00000037534.7
Rnf167
ring finger protein 167
chr2_-_160872985 0.580 ENSMUST00000109460.1
ENSMUST00000127201.1
Zhx3

zinc fingers and homeoboxes 3

chr11_+_60537978 0.578 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr10_-_80798476 0.573 ENSMUST00000036805.5
Plekhj1
pleckstrin homology domain containing, family J member 1
chr5_-_143269958 0.572 ENSMUST00000161448.1
Zfp316
zinc finger protein 316
chr10_+_80798652 0.556 ENSMUST00000151928.1
Sf3a2
splicing factor 3a, subunit 2
chr15_+_89355730 0.555 ENSMUST00000074552.5
ENSMUST00000088717.6
Ncaph2

non-SMC condensin II complex, subunit H2

chr15_+_80091320 0.546 ENSMUST00000009728.6
ENSMUST00000009727.5
Syngr1

synaptogyrin 1

chr8_-_70659645 0.545 ENSMUST00000070173.7
Pgpep1
pyroglutamyl-peptidase I
chr15_-_97767798 0.545 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr12_-_79296266 0.544 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr7_+_82337218 0.525 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chr2_+_32535315 0.524 ENSMUST00000133512.1
ENSMUST00000048375.5
Fam102a

family with sequence similarity 102, member A

chr9_-_45936049 0.521 ENSMUST00000034590.2
Tagln
transgelin
chr6_-_115251839 0.513 ENSMUST00000032462.6
Timp4
tissue inhibitor of metalloproteinase 4
chr7_+_24884651 0.509 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr3_+_146499828 0.508 ENSMUST00000090031.5
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr17_+_46646225 0.504 ENSMUST00000002844.7
ENSMUST00000113429.1
ENSMUST00000113430.1
Mrpl2


mitochondrial ribosomal protein L2


chr17_-_24696147 0.501 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr15_+_89355716 0.500 ENSMUST00000036987.5
Ncaph2
non-SMC condensin II complex, subunit H2
chr15_+_103453782 0.495 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chr2_-_160872829 0.495 ENSMUST00000176141.1
Zhx3
zinc fingers and homeoboxes 3
chr18_-_74961252 0.491 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr1_-_75506331 0.479 ENSMUST00000113567.2
ENSMUST00000113565.2
Obsl1

obscurin-like 1

chr1_+_191098414 0.470 ENSMUST00000027943.4
Batf3
basic leucine zipper transcription factor, ATF-like 3
chr7_-_43489967 0.468 ENSMUST00000107974.1
Iglon5
IgLON family member 5
chr4_-_154160632 0.465 ENSMUST00000105639.3
ENSMUST00000030896.8
Tprgl

transformation related protein 63 regulated like

chr7_-_25477607 0.465 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr19_+_46305682 0.451 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr7_+_45705518 0.451 ENSMUST00000107740.1
ENSMUST00000107741.1
Dbp

D site albumin promoter binding protein

chr15_-_97767244 0.450 ENSMUST00000146620.1
Rapgef3
Rap guanine nucleotide exchange factor (GEF) 3
chr3_+_146499850 0.447 ENSMUST00000118280.1
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr5_+_24452177 0.445 ENSMUST00000024123.4
Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr11_+_75655873 0.443 ENSMUST00000108431.2
Myo1c
myosin IC
chr5_-_140649018 0.440 ENSMUST00000042661.3
Ttyh3
tweety homolog 3 (Drosophila)
chr1_+_87183310 0.439 ENSMUST00000044533.8
Prss56
protease, serine 56
chr11_-_62539257 0.414 ENSMUST00000018653.1
Cenpv
centromere protein V
chr14_+_65358661 0.412 ENSMUST00000066994.6
Zfp395
zinc finger protein 395
chr4_-_132922487 0.409 ENSMUST00000097856.3
Fam76a
family with sequence similarity 76, member A
chr12_-_25096080 0.398 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr13_-_43560174 0.397 ENSMUST00000021800.4
Mcur1
mitochondrial calcium uniporter regulator 1
chr3_+_94377505 0.396 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr11_+_85832551 0.392 ENSMUST00000000095.6
Tbx2
T-box 2
chr2_-_160872552 0.392 ENSMUST00000103111.2
Zhx3
zinc fingers and homeoboxes 3
chr4_+_133039482 0.385 ENSMUST00000105914.1
Ahdc1
AT hook, DNA binding motif, containing 1
chr15_-_50890396 0.380 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr11_-_102407455 0.376 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39

chr17_-_7827289 0.375 ENSMUST00000167580.1
ENSMUST00000169126.1
Fndc1

fibronectin type III domain containing 1

chr6_+_43265582 0.375 ENSMUST00000031750.7
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr11_+_70657687 0.374 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr11_+_114851507 0.373 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr2_+_27709247 0.369 ENSMUST00000100251.2
Rxra
retinoid X receptor alpha
chr18_-_38250558 0.360 ENSMUST00000181757.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr11_+_121702591 0.356 ENSMUST00000125580.1
Metrnl
meteorin, glial cell differentiation regulator-like
chr5_+_64160207 0.356 ENSMUST00000101195.2
Tbc1d1
TBC1 domain family, member 1
chr17_-_25868727 0.355 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr8_-_105264586 0.355 ENSMUST00000034359.3
Tradd
TNFRSF1A-associated via death domain
chrX_-_51205990 0.351 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr4_+_139574697 0.349 ENSMUST00000174078.1
Iffo2
intermediate filament family orphan 2
chr7_+_43463145 0.344 ENSMUST00000107977.1
Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chr13_-_32802849 0.343 ENSMUST00000057911.1
D930007J09Rik
RIKEN cDNA D930007J09 gene
chr8_+_123477859 0.342 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr15_-_75909543 0.340 ENSMUST00000123712.1
ENSMUST00000141475.1
ENSMUST00000144614.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr10_-_58675631 0.339 ENSMUST00000003312.4
Edar
ectodysplasin-A receptor
chr2_+_28205648 0.337 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1

olfactomedin 1

chr2_-_168742100 0.332 ENSMUST00000109177.1
Atp9a
ATPase, class II, type 9A
chr11_+_70657196 0.331 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr11_-_102407315 0.331 ENSMUST00000149777.1
ENSMUST00000154001.1
Slc25a39

solute carrier family 25, member 39

chr5_-_142905928 0.329 ENSMUST00000106216.2
Actb
actin, beta
chr10_-_13388753 0.326 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chrM_-_14060 0.324 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_-_180813534 0.318 ENSMUST00000159789.1
ENSMUST00000081026.4
H3f3a

H3 histone, family 3A

chr2_-_38644087 0.314 ENSMUST00000028083.5
Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr19_-_4615453 0.313 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr14_-_31128924 0.308 ENSMUST00000064032.4
ENSMUST00000049732.5
ENSMUST00000090205.3
Smim4


small itegral membrane protein 4


chr11_-_69579320 0.306 ENSMUST00000048139.5
Wrap53
WD repeat containing, antisense to Trp53
chr4_+_116877376 0.301 ENSMUST00000044823.3
Zswim5
zinc finger SWIM-type containing 5
chr7_-_19399859 0.300 ENSMUST00000047170.3
ENSMUST00000108459.2
Klc3

kinesin light chain 3

chr11_-_102897146 0.299 ENSMUST00000077902.4
Gfap
glial fibrillary acidic protein
chr2_+_172550991 0.297 ENSMUST00000170744.1
Tfap2c
transcription factor AP-2, gamma
chr11_-_72796028 0.294 ENSMUST00000156294.1
Cyb5d2
cytochrome b5 domain containing 2
chr6_+_124931378 0.294 ENSMUST00000032214.7
ENSMUST00000180095.1
Mlf2

myeloid leukemia factor 2

chr11_-_70687917 0.289 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr15_+_78428564 0.289 ENSMUST00000166142.2
ENSMUST00000162517.1
ENSMUST00000089414.4
Kctd17


potassium channel tetramerisation domain containing 17


chr5_-_101665195 0.289 ENSMUST00000044125.8
Nkx6-1
NK6 homeobox 1
chr11_+_60104971 0.288 ENSMUST00000064190.6
Rai1
retinoic acid induced 1
chr7_+_97480928 0.288 ENSMUST00000026126.8
Ints4
integrator complex subunit 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0036166 phenotypic switching(GO:0036166)
0.8 2.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.8 2.3 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.4 2.2 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.4 0.9 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.4 1.6 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.4 2.0 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.4 1.1 GO:0010643 cell communication by chemical coupling(GO:0010643) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.4 1.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.7 GO:1904426 positive regulation of GTP binding(GO:1904426)
0.3 2.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.3 1.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3 1.0 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.3 0.9 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.3 0.9 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 1.7 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795)
0.3 1.1 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.3 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 0.8 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.3 1.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) protein kinase D signaling(GO:0089700)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.0 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.2 1.2 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2 1.4 GO:0019346 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.2 1.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.7 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 0.2 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.2 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.2 1.1 GO:0051309 female meiosis chromosome separation(GO:0051309)
0.2 0.8 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.2 0.6 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.2 0.6 GO:0046098 guanine metabolic process(GO:0046098)
0.2 1.2 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.2 0.4 GO:0060596 mammary placode formation(GO:0060596)
0.2 0.6 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 1.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 1.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 0.7 GO:0015744 succinate transport(GO:0015744)
0.2 0.8 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.2 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 1.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.6 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.9 GO:0060242 contact inhibition(GO:0060242)
0.1 1.0 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.8 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.7 GO:0015671 oxygen transport(GO:0015671)
0.1 1.4 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541)
0.1 2.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.4 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.1 0.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.5 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 1.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.7 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.7 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.4 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.7 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 0.2 GO:2000054 regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 0.7 GO:0042473 outer ear morphogenesis(GO:0042473)
0.1 1.3 GO:0060033 anatomical structure regression(GO:0060033)
0.1 0.3 GO:0061325 extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.1 0.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 0.4 GO:0030578 PML body organization(GO:0030578)
0.1 0.8 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.1 0.6 GO:0021796 cerebral cortex regionalization(GO:0021796) radial glial cell differentiation(GO:0060019)
0.1 0.8 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.6 GO:0042182 ketone catabolic process(GO:0042182)
0.0 0.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 1.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.5 GO:0002716 negative regulation of natural killer cell mediated immunity(GO:0002716) negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
0.0 0.9 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.9 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.3 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.3 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.9 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.5 GO:0002467 germinal center formation(GO:0002467)
0.0 0.1 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0 0.3 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.8 GO:0009299 mRNA transcription(GO:0009299)
0.0 0.2 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281)
0.0 1.6 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 1.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.2 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.3 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.2 GO:0072189 ureter development(GO:0072189)
0.0 0.9 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.6 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.3 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 1.3 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.4 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.1 GO:0014823 response to activity(GO:0014823)
0.0 0.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.5 1.4 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 1.6 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.3 0.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 1.1 GO:1902737 dendritic filopodium(GO:1902737)
0.3 2.0 GO:0031415 NatA complex(GO:0031415)
0.2 0.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 0.9 GO:0060187 cell pole(GO:0060187)
0.2 1.1 GO:0005859 muscle myosin complex(GO:0005859)
0.2 0.3 GO:0070469 respiratory chain(GO:0070469)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 0.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.2 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 1.7 GO:0042555 MCM complex(GO:0042555)
0.1 1.1 GO:0000796 condensin complex(GO:0000796)
0.1 0.3 GO:0005745 m-AAA complex(GO:0005745)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 1.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.9 GO:0000346 transcription export complex(GO:0000346)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0005771 multivesicular body(GO:0005771)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.6 GO:0071004 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.0 8.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 1.6 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.4 2.0 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.4 1.1 GO:0005118 sevenless binding(GO:0005118)
0.4 2.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 1.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 1.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 0.9 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 2.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 1.4 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.3 0.8 GO:0070052 collagen V binding(GO:0070052)
0.3 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.2 GO:0005534 galactose binding(GO:0005534)
0.2 0.7 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.2 1.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 1.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 0.6 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 0.6 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 0.7 GO:0004096 catalase activity(GO:0004096)
0.1 0.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.9 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.6 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.3 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 0.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 1.3 GO:0005522 profilin binding(GO:0005522)
0.1 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 1.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.3 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.1 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 1.4 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0051861 glycolipid binding(GO:0051861)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.2 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 2.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 ST_GAQ_PATHWAY G alpha q Pathway
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 2.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 0.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.1 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 0.9 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 5.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.1 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1 1.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.7 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.2 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)