Motif ID: Klf8

Z-value: 0.538


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.342.7e-03Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127026479 2.318 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr19_+_5740885 2.314 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr14_+_28511344 2.270 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr16_+_30599717 1.697 ENSMUST00000059078.3
 Fam43a
family with sequence similarity 43, member A
chr11_+_69632927 1.696 ENSMUST00000018909.3
 Fxr2
fragile X mental retardation, autosomal homolog 2
chr1_-_20820213 1.685 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr17_-_70851189 1.602 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr17_+_34898931 1.592 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr2_-_36105271 1.553 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chrX_+_161717055 1.549 ENSMUST00000112338.1
 Rai2
retinoic acid induced 2
chr3_+_90541146 1.396 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16


chr11_-_32222233 1.363 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 1.299 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr13_+_49187485 1.297 ENSMUST00000049022.8
ENSMUST00000120733.1
 Ninj1

ninjurin 1

chr7_-_142657466 1.266 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr7_+_100495987 1.254 ENSMUST00000133044.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chrX_+_96096034 1.226 ENSMUST00000117399.1
 Msn
moesin
chr5_+_139423151 1.218 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr1_+_172499948 1.202 ENSMUST00000111230.1
 Tagln2
transgelin 2
chr2_+_179893909 1.197 ENSMUST00000098996.1
 Gm10711
predicted gene 10711

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.8 2.5 GO:0036166 phenotypic switching(GO:0036166)
0.8 2.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.8 2.3 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.3 2.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.4 2.2 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.4 2.0 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.3 1.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) protein kinase D signaling(GO:0089700)
0.3 1.7 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795)
0.0 1.7 GO:0006270 DNA replication initiation(GO:0006270)
0.4 1.6 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.3 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.6 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2 1.4 GO:0019346 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.1 1.4 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 1.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 1.3 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
0.3 2.0 GO:0031415 NatA complex(GO:0031415)
0.1 1.7 GO:0042555 MCM complex(GO:0042555)
0.0 1.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 1.6 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 1.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.6 GO:0005844 polysome(GO:0005844)
0.5 1.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.5 1.4 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.2 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.3 1.1 GO:1902737 dendritic filopodium(GO:1902737)
0.2 1.1 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.1 GO:0000796 condensin complex(GO:0000796)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 0.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 0.9 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 2.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.8 2.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.3 2.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.4 2.0 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 1.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 1.4 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.4 GO:0004697 protein kinase C activity(GO:0004697)
0.3 1.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 1.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.3 GO:0005522 profilin binding(GO:0005522)
0.1 1.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 2.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.1 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 0.9 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation