Motif ID: Lef1

Z-value: 1.664


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.561.0e-07Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 22.979 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr10_-_92165159 20.879 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr2_+_70474923 19.364 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr7_-_37772868 17.296 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr7_-_115824699 16.077 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr18_-_62756275 15.853 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr4_-_91376490 13.293 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_91376433 13.232 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr12_+_76072016 13.149 ENSMUST00000131480.1
 Syne2
spectrin repeat containing, nuclear envelope 2
chr4_+_8691303 12.680 ENSMUST00000051558.3
 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_116067213 12.508 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_-_34882919 12.157 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr1_-_165934900 12.053 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1


chr2_-_116067391 11.837 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr19_+_55742242 11.802 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr3_+_102010138 11.639 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr1_-_138842429 11.197 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr7_-_37773555 11.099 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr5_-_28210022 10.874 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr7_-_116038734 10.832 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 49.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.6 28.5 GO:0048625 myoblast fate commitment(GO:0048625)
2.4 26.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
7.7 23.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.9 21.5 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.4 17.7 GO:0060612 adipose tissue development(GO:0060612)
2.5 17.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 17.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.7 17.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.6 16.7 GO:0070207 protein homotrimerization(GO:0070207)
4.8 14.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
2.9 14.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
1.3 14.4 GO:0060539 diaphragm development(GO:0060539)
0.8 14.3 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
2.0 13.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
4.5 13.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.7 13.4 GO:0030903 notochord development(GO:0030903)
4.2 12.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 11.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 11.4 GO:0006338 chromatin remodeling(GO:0006338)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 85.8 GO:0005634 nucleus(GO:0005634)
0.2 66.0 GO:0005667 transcription factor complex(GO:0005667)
3.3 36.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 16.8 GO:0072686 mitotic spindle(GO:0072686)
4.2 16.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.8 14.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
3.3 13.1 GO:0008623 CHRAC(GO:0008623)
0.2 10.2 GO:1990391 DNA repair complex(GO:1990391)
0.4 10.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 9.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 9.9 GO:0005871 kinesin complex(GO:0005871)
3.1 9.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 9.1 GO:0005802 trans-Golgi network(GO:0005802)
0.4 8.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 7.6 GO:0005635 nuclear envelope(GO:0005635)
0.6 7.2 GO:0030057 desmosome(GO:0030057)
0.1 7.1 GO:0032993 protein-DNA complex(GO:0032993)
0.3 6.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.1 6.4 GO:0000235 astral microtubule(GO:0000235)
0.5 6.2 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 96.1 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.3 51.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.8 38.7 GO:0045295 gamma-catenin binding(GO:0045295)
2.4 35.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.9 23.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.4 21.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.0 20.3 GO:0030215 semaphorin receptor binding(GO:0030215)
2.5 19.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 15.9 GO:0003777 microtubule motor activity(GO:0003777)
0.6 14.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 14.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 14.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.7 13.1 GO:0070411 I-SMAD binding(GO:0070411)
0.3 11.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 10.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 10.7 GO:0003677 DNA binding(GO:0003677)
0.3 9.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.4 9.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 9.4 GO:0003713 transcription coactivator activity(GO:0003713)
1.5 9.3 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 74.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.8 39.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 21.2 PID_E2F_PATHWAY E2F transcription factor network
0.5 14.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.5 14.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.2 14.0 PID_PLK1_PATHWAY PLK1 signaling events
0.3 12.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 12.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 12.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.0 9.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 9.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 7.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 5.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 5.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 4.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.3 4.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 4.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.9 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 28.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 21.9 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
2.8 16.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.0 16.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 14.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.7 13.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 10.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 8.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 7.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 7.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 6.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.4 5.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 4.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.3 4.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.3 4.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 4.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 4.0 REACTOME_KINESINS Genes involved in Kinesins
0.3 3.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 3.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1