Motif ID: Lhx2_Hoxc5

Z-value: 0.785

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.342.7e-03Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 14.342 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 7.078 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr14_-_64455903 6.484 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr18_+_37435602 5.532 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr19_-_32196393 5.485 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr4_-_14621494 4.563 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 4.533 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_138396438 4.281 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr19_-_11604828 4.267 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr3_+_63295815 4.244 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr2_+_65620829 4.211 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr15_-_37459327 4.193 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_+_102589687 4.172 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chrY_+_90785442 4.049 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr8_+_66386292 3.987 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr1_+_58210397 3.979 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr9_+_53771499 3.859 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr7_-_45103747 3.848 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr3_+_9403049 3.699 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr6_+_116650674 3.659 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 23.4 GO:0019532 oxalate transport(GO:0019532)
0.0 8.4 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 7.3 GO:0007416 synapse assembly(GO:0007416)
0.6 5.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.8 5.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.4 5.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.5 4.5 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 4.5 GO:0007568 aging(GO:0007568)
0.3 4.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 4.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.3 4.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 4.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.3 3.8 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 3.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.5 3.7 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.5 3.6 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.2 3.6 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 3.6 GO:0015809 arginine transport(GO:0015809)
1.1 3.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.8 3.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 8.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 7.4 GO:0070469 respiratory chain(GO:0070469)
0.2 6.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.5 5.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.3 5.1 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 4.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 4.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 3.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.8 3.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 3.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 3.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 3.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.2 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 23.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 7.0 GO:0050840 extracellular matrix binding(GO:0050840)
2.2 6.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 6.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 5.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
1.1 5.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 5.5 GO:0042287 MHC protein binding(GO:0042287)
0.2 5.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 4.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.0 4.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 3.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 3.8 GO:0019770 IgG receptor activity(GO:0019770)
0.8 3.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 3.8 GO:0008201 heparin binding(GO:0008201)
0.4 3.5 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.3 3.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.8 3.3 GO:0031720 haptoglobin binding(GO:0031720)
0.3 3.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.8 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 2.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.0 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 1.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 1.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.7 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 26.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 8.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 7.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 4.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 4.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 4.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 3.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 3.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 3.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.4 2.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 2.3 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 2.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 1.9 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors