Motif ID: Lhx3

Z-value: 0.917


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 16.965 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr7_-_103827922 14.941 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 12.913 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr17_-_67950908 9.669 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr4_-_14621494 9.403 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_+_136143497 9.101 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr4_-_14621669 8.571 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_+_102589687 8.326 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr19_+_26623419 8.319 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_33087169 7.338 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_125136692 7.043 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr2_-_33086366 6.903 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_64090265 6.868 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_96115249 6.694 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr1_-_38821215 6.664 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_+_66968961 6.476 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr13_-_101692624 6.421 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_-_164171113 6.250 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr10_-_33624587 6.071 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr14_+_80000292 6.047 ENSMUST00000088735.3
 Olfm4
olfactomedin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 34.9 GO:0019532 oxalate transport(GO:0019532)
0.0 14.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.7 10.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
2.4 9.7 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 9.1 GO:0030903 notochord development(GO:0030903)
0.9 8.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 8.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 6.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.5 6.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 6.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 6.4 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 6.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 6.1 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 6.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 4.9 GO:0021766 hippocampus development(GO:0021766)
0.7 4.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.2 4.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.8 4.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 4.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 3.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.7 GO:0016323 basolateral plasma membrane(GO:0016323)
3.7 14.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 10.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 9.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.4 8.3 GO:0071564 npBAF complex(GO:0071564)
0.3 8.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 7.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 6.5 GO:0043034 costamere(GO:0043034)
0.3 6.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 6.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 6.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 6.0 GO:0042581 specific granule(GO:0042581)
1.0 4.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.6 3.2 GO:0032437 cuticular plate(GO:0032437)
0.5 3.0 GO:0005955 calcineurin complex(GO:0005955)
0.3 2.7 GO:0042629 mast cell granule(GO:0042629)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 2.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 2.2 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 34.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 16.1 GO:0005096 GTPase activator activity(GO:0005096)
3.7 14.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.6 12.9 GO:0019770 IgG receptor activity(GO:0019770)
0.1 9.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 8.9 GO:0005504 fatty acid binding(GO:0005504)
0.3 8.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 8.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 6.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 6.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
1.6 6.4 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.3 6.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 6.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 5.3 GO:0008083 growth factor activity(GO:0008083)
0.0 4.8 GO:0003779 actin binding(GO:0003779)
0.2 4.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.8 4.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.8 4.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.6 3.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 3.4 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 6.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 4.1 PID_MYC_PATHWAY C-MYC pathway
0.0 4.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 11.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 8.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 6.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 6.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 5.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 4.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 2.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA