Motif ID: Lhx4

Z-value: 1.386


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478182 32.578 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 30.750 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_160619971 19.536 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr17_-_48432723 18.571 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr4_-_97778042 18.566 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_-_37769624 18.281 ENSMUST00000175941.1
 Zfp536
zinc finger protein 536
chr7_-_37773555 17.169 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr7_-_37772868 16.674 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr13_-_97747373 14.836 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 14.584 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr10_+_79996479 13.865 ENSMUST00000132517.1
 Abca7
ATP-binding cassette, sub-family A (ABC1), member 7
chr7_-_49636847 13.818 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr5_-_62766153 13.548 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_28210022 13.490 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr14_-_48665098 13.345 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr15_+_25752860 12.751 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr4_-_45532470 12.446 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr10_+_37139558 11.015 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_-_28916412 10.845 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr2_-_79456750 10.721 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
21.1 63.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.3 52.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.3 22.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.5 22.5 GO:0030901 midbrain development(GO:0030901)
6.2 18.6 GO:0016554 cytidine to uridine editing(GO:0016554)
3.7 18.4 GO:0038027 apolipoprotein A-I-mediated signaling pathway(GO:0038027)
2.5 17.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.1 15.9 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
3.4 13.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
3.3 13.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.4 13.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 12.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.4 12.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
2.7 10.7 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.8 10.3 GO:0072189 ureter development(GO:0072189)
0.3 10.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
3.3 9.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
1.9 9.6 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 9.6 GO:0006906 vesicle fusion(GO:0006906)
0.5 9.2 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 114.5 GO:0005634 nucleus(GO:0005634)
0.1 23.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.2 17.8 GO:0045180 basal cortex(GO:0045180)
0.4 15.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 13.9 GO:0001891 phagocytic cup(GO:0001891)
0.6 13.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
3.3 13.1 GO:0060187 cell pole(GO:0060187)
0.2 12.8 GO:0016459 myosin complex(GO:0016459)
0.1 12.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 10.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 9.6 GO:0070382 exocytic vesicle(GO:0070382)
0.2 9.2 GO:0002102 podosome(GO:0002102)
1.1 8.7 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 7.0 GO:0016607 nuclear speck(GO:0016607)
0.0 6.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
1.7 5.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
1.0 5.1 GO:0031523 Myb complex(GO:0031523)
0.1 5.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.5 4.5 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 84.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
3.5 52.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 43.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 20.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
4.6 18.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 18.4 GO:0045296 cadherin binding(GO:0045296)
0.3 17.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
4.6 13.9 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 13.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 12.8 GO:0030507 spectrin binding(GO:0030507)
0.4 11.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 10.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 10.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 10.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 9.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 8.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 8.9 GO:0008013 beta-catenin binding(GO:0008013)
0.7 8.7 GO:0070513 death domain binding(GO:0070513)
2.8 8.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.6 8.4 GO:0035497 cAMP response element binding(GO:0035497)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 63.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.5 23.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.7 22.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.3 13.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 10.9 PID_ARF6_PATHWAY Arf6 signaling events
0.2 10.3 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 9.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 8.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 8.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.3 8.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 5.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 4.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.3 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.8 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 13.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.5 13.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 12.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 10.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 10.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
1.2 8.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 8.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 7.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 7.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 6.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.3 5.2 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.5 5.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.9 4.5 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 4.5 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 4.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.4 4.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 4.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 3.7 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.2 2.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)