Motif ID: Lhx5_Lmx1b_Lhx1
Z-value: 0.608



Transcription factors associated with Lhx5_Lmx1b_Lhx1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Lhx1 | ENSMUSG00000018698.9 | Lhx1 |
Lhx5 | ENSMUSG00000029595.7 | Lhx5 |
Lmx1b | ENSMUSG00000038765.7 | Lmx1b |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Lhx5 | mm10_v2_chr5_+_120431770_120431905 | -0.37 | 9.9e-04 | Click! |
Lhx1 | mm10_v2_chr11_-_84525514_84525542 | -0.32 | 5.2e-03 | Click! |
Lmx1b | mm10_v2_chr2_-_33640480_33640511 | -0.19 | 9.4e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 93 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 11.8 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.8 | 11.0 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
1.2 | 8.3 | GO:0019532 | oxalate transport(GO:0019532) |
1.5 | 7.4 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
0.3 | 4.7 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.3 | 4.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.1 | 4.4 | GO:0045761 | regulation of adenylate cyclase activity(GO:0045761) |
0.1 | 3.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
1.1 | 3.2 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.3 | 2.9 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.1 | 2.7 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.4 | 2.4 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.1 | 2.3 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 2.2 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
0.5 | 1.9 | GO:0042420 | dopamine catabolic process(GO:0042420) |
0.3 | 1.7 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
0.2 | 1.7 | GO:1902741 | type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
0.3 | 1.6 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.0 | 1.5 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
0.3 | 1.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 50 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 10.5 | GO:0031965 | nuclear membrane(GO:0031965) |
0.4 | 9.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 7.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 5.1 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.2 | 2.7 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 2.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 2.3 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.0 | 1.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 1.9 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
0.3 | 1.8 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 1.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.1 | 1.4 | GO:0000346 | transcription export complex(GO:0000346) |
0.3 | 1.1 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 1.1 | GO:0071439 | clathrin complex(GO:0071439) |
0.1 | 1.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 1.1 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 1.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 1.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 67 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 11.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.1 | 8.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.8 | 8.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
2.5 | 7.4 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
0.1 | 4.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.2 | 4.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.0 | 4.3 | GO:0008017 | microtubule binding(GO:0008017) |
0.9 | 3.7 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.2 | 3.2 | GO:0030275 | LRR domain binding(GO:0030275) |
0.7 | 2.9 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
0.1 | 2.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.5 | 1.9 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
0.0 | 1.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
0.3 | 1.8 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.1 | 1.7 | GO:0038191 | neuropilin binding(GO:0038191) |
0.5 | 1.5 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
0.0 | 1.4 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 1.2 | GO:0004407 | histone deacetylase activity(GO:0004407) |
0.4 | 1.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.1 | 1.1 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
Gene overrepresentation in C2:CP category:
Showing 1 to 16 of 16 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 6.0 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.1 | 4.7 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 3.5 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 2.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.1 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
0.0 | 1.1 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
0.0 | 1.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 1.0 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 1.0 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.7 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 0.6 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 0.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 0.5 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
0.0 | 0.5 | PID_BCR_5PATHWAY | BCR signaling pathway |
0.0 | 0.3 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 27 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 11.0 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.1 | 8.3 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 7.5 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 5.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 4.8 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
0.1 | 4.4 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
0.4 | 3.7 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 3.1 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.1 | 2.1 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.1 | 2.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.2 | 1.9 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
0.1 | 1.2 | REACTOME_ARMS_MEDIATED_ACTIVATION | Genes involved in ARMS-mediated activation |
0.1 | 1.1 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
0.0 | 1.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.0 | 1.0 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.1 | 0.9 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.7 | REACTOME_PLC_BETA_MEDIATED_EVENTS | Genes involved in PLC beta mediated events |
0.0 | 0.6 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.0 | 0.6 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
0.0 | 0.6 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |