Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.608

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.379.9e-04Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.325.2e-03Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.199.4e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93595877 11.768 ENSMUST00000048982.4
Prickle1
prickle homolog 1 (Drosophila)
chr3_+_121953213 7.790 ENSMUST00000037958.7
ENSMUST00000128366.1
Arhgap29

Rho GTPase activating protein 29

chr18_-_66860458 7.355 ENSMUST00000057942.2
Mc4r
melanocortin 4 receptor
chr4_+_102589687 6.856 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr4_-_14621805 5.938 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr7_+_66365905 4.897 ENSMUST00000107486.1
Gm10974
predicted gene 10974
chr11_-_87359011 4.531 ENSMUST00000055438.4
Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr13_+_46502113 4.363 ENSMUST00000119341.1
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr15_-_67113909 3.748 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr4_+_145585166 3.669 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr2_+_68104671 2.906 ENSMUST00000042456.3
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_143933089 2.732 ENSMUST00000087313.3
Dcx
doublecortin
chr14_+_80000292 2.725 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_77135513 2.714 ENSMUST00000168779.1
2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr8_+_34054622 2.692 ENSMUST00000149618.1
Gm9951
predicted gene 9951
chr4_+_102421518 2.462 ENSMUST00000106904.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_33718789 2.282 ENSMUST00000130532.1
9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr8_-_67910911 2.277 ENSMUST00000093468.5
Psd3
pleckstrin and Sec7 domain containing 3
chr5_+_130369420 2.255 ENSMUST00000086029.3
Caln1
calneuron 1
chrX_-_143933204 1.939 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.8 11.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.2 8.3 GO:0019532 oxalate transport(GO:0019532)
1.5 7.4 GO:0002024 diet induced thermogenesis(GO:0002024)
0.3 4.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 4.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 4.4 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.1 3.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
1.1 3.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 2.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 2.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 2.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.5 1.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.3 1.7 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.7 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.3 1.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 1.5 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.3 1.4 GO:0035063 nuclear speck organization(GO:0035063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.5 GO:0031965 nuclear membrane(GO:0031965)
0.4 9.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 7.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.7 GO:0042581 specific granule(GO:0042581)
0.1 2.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0031968 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.3 1.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.4 GO:0000346 transcription export complex(GO:0000346)
0.3 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.1 GO:0071439 clathrin complex(GO:0071439)
0.1 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 1.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 8.9 GO:0030165 PDZ domain binding(GO:0030165)
0.8 8.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
2.5 7.4 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 4.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 4.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 4.3 GO:0008017 microtubule binding(GO:0008017)
0.9 3.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 3.2 GO:0030275 LRR domain binding(GO:0030275)
0.7 2.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 1.9 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 1.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 1.8 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.7 GO:0038191 neuropilin binding(GO:0038191)
0.5 1.5 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 1.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 1.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.1 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 8.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 7.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 4.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 3.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 1.9 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.2 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.1 1.1 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling