Motif ID: Lhx8

Z-value: 0.576


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_1543305760.113.5e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66227573 3.248 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr1_+_6487231 3.079 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr11_+_44617310 2.686 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr12_+_38783455 2.480 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr13_-_66851513 2.443 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr12_+_38783503 2.397 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr2_-_72986716 2.394 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr2_-_67433181 2.104 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr13_+_5861489 1.985 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr4_-_155645408 1.853 ENSMUST00000115821.2
Gm10563
predicted gene 10563
chr8_-_57653023 1.751 ENSMUST00000034021.5
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr13_-_66852017 1.742 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr10_-_67912620 1.577 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr1_-_127677923 1.538 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr8_-_57652993 1.496 ENSMUST00000110316.2
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr4_+_126556994 1.299 ENSMUST00000147675.1
Clspn
claspin
chr13_+_65512678 1.259 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr8_+_45627709 1.251 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr17_-_90088343 1.241 ENSMUST00000173917.1
Nrxn1
neurexin I
chr14_+_60768120 1.202 ENSMUST00000025940.6
C1qtnf9
C1q and tumor necrosis factor related protein 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 3.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 3.0 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 2.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.5 1.6 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 1.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 1.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 1.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.8 GO:0007608 sensory perception of smell(GO:0007608)
0.2 0.5 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.5 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.5 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 0.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0043083 synaptic cleft(GO:0043083)
0.2 0.9 GO:0031673 H zone(GO:0031673)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.1 GO:0001047 core promoter binding(GO:0001047)
0.2 2.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.4 2.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.2 GO:0005179 hormone activity(GO:0005179)
0.1 1.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.5 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)